Pressure ulcers (PUs) impose a significant economic burden on healthcare systems, affecting patient quality of life and leading to substantial treatment costs. This study presents a cost-of-illness analysis of PU treatment in hospitalized patients in the Czech Republic, based on real-world clinical data. The analysis was conducted using a comprehensive methodology at a Czech university hospital, involving 304 hospitalizations. The study included all hospitalized patients with PUs. Data were collected employing a bottom-up, person-based approach, which refers to the collection and analysis of cost data at the individual patient level. This method captures detailed resource utilization for each patient. The methodology accounted for both systemic and local costs, including materials, medications, caregiver time, and procedures. The study involved 304 hospitalizations, with a mean length of stay of 13 days. The total cost of PU treatment, excluding pharmacotherapy, had a median of €678, while including pharmacotherapy, the median cost rose to €929. Younger patients incurred higher treatment costs. Significant cost variations were observed among different departments. We developed and applied a novel cost model to quantify the expenses associated with PUs, which accurately highlighted the financial burden in the hospital care setting. We present a rigorous methodology for PU cost-of-illness analysis, providing a valuable tool for future research and clinical practice. This comprehensive approach supports the development of targeted interventions to reduce the incidence and severity of PUs, ultimately improving patient care and reducing healthcare costs.

• MeSH
• Pressure Ulcer * economics   therapy   MeSH
• Length of Stay economics   statistics & numerical data   MeSH
• Adult MeSH
• Hospitalization economics   MeSH
• Middle Aged MeSH
• Humans MeSH
• Health Care Costs statistics & numerical data   MeSH
• Hospitals, University * economics   MeSH
• Cost of Illness * MeSH
• Aged, 80 and over MeSH
• Aged MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Aged, 80 and over MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Geographicals
• Czech Republic MeSH

BACKGROUND: Conservative treatment of chronic pancreatitis has only a limited effect in most patients. Surgery offers very good long-term results, even in the early stages of the disease. Unfortunately, only a minority of patients undergo surgical treatment. The aim of this work was to summarise the current treatment options for patients with an inflammatory mass of the pancreatic head. Data from patients in our study demonstrates that the surgery is a safe method, and here we compare the perioperative and early postoperative outcomes of patients who underwent a pancreatoduodenectomy and duodenum-preserving pancreatic head resection for chronic pancreatitis. METHODS: All patients who underwent a pancreaticoduodenectomy or a duodenum-preserving pancreatic head resection in our department between 2014 and 2022 were included in this study. Perioperative and early postoperative results were statistically analysed and compared. RESULTS: Thirty-eight pancreaticoduodenectomies and 23 duodenum-preserving pancreatic head resections were performed. The overall mortality was 3%, whereas the in-hospital mortality after pancreaticoduodenectomy was 5%. The mortality after duodenum-preserving pancreatic head resection was 0%. No statistically significant differences in the hospital stay, blood loss, and serious morbidity were found in either surgery. Operative time was significantly shorter in the duodenum-preserving pancreatic head resection group. CONCLUSIONS: Both pancreatoduodenectomy and duodenum-preserving pancreatic head resection are safe treatment options. Duodenum-preserving pancreatic head resection showed a statistically significant superiority in the operative time compared to pancreaticoduodenectomy. Although other monitored parameters did not show a statistically significant difference, the high risk of complications after pancreaticoduodenectomy with a mortality of 5%; maintenance of the duodenum and upper loop of jejunum, and lower risk of metabolic dysfunctions after duodenum-preserving pancreatic head resection may favour duodenum-preserving pancreatic head resection in recommended diagnoses. Attending physicians should be more encouraged to use a multidisciplinary approach to assess the suitability of surgical treatment in patients with chronic pancreatitis.

• MeSH
• Pancreatitis, Chronic * surgery   MeSH
• Operative Time * MeSH
• Length of Stay statistics & numerical data   MeSH
• Adult MeSH
• Duodenum surgery   pathology   MeSH
• Organ Sparing Treatments methods   MeSH
• Middle Aged MeSH
• Humans MeSH
• Hospital Mortality MeSH
• Pancreas * surgery   pathology   MeSH
• Pancreatectomy methods   adverse effects   MeSH
• Pancreaticoduodenectomy * methods   adverse effects   MeSH
• Postoperative Complications etiology   epidemiology   MeSH
• Retrospective Studies MeSH
• Aged MeSH
• Treatment Outcome MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH

STUDY OBJECTIVE: Male sex has inconsistently been associated with the development of postoperative pulmonary complications (PPCs). These studies were different in size, design, population and preoperative risk. We reanalysed the database of 'Local ASsessment of Ventilatory management during General Anaesthesia for Surgery study' (LAS VEGAS) to evaluate differences between females and males with respect to PPCs. DESIGN, SETTING AND PATIENTS: Post hoc unmatched and matched analysis of LAS VEGAS, an international observational study in patients undergoing intraoperative ventilation under general anaesthesia for surgery in 146 hospitals across 29 countries. The primary endpoint was a composite of PPCs in the first 5 postoperative days. Individual PPCs, hospital length of stay and mortality were secondary endpoints. Propensity score matching was used to create a similar cohort regarding type of surgery and epidemiological factors with a known association with development of PPCs. MAIN RESULTS: The unmatched cohort consisted of 9697 patients; 5342 (55.1%) females and 4355 (44.9%) males. The matched cohort consisted of 6154 patients; 3077 (50.0%) females and 3077 (50.0%) males. The incidence in PPCs was neither significant between females and males in the unmatched cohort (10.0 vs 10.7%; odds ratio (OR) 0.93 [0.81-1.06]; P = 0.255), nor in the matched cohort (10.5 vs 10.0%; OR 1.05 [0.89-1.25]; P = 0.556). New invasive ventilation occurred less often in females in the unmatched cohort. Hospital length of stay and mortality were similar between females and males in both cohorts. CONCLUSIONS: In this conveniently-sized worldwide cohort of patients receiving intraoperative ventilation under general anaesthesia for surgery, the PPC incidence was not significantly different between sexes. REGISTRATION: LAS VEGAS was registered at clinicaltrial.gov (study identifier NCT01601223).

• MeSH
• Anesthesia, General * adverse effects   MeSH
• Length of Stay * statistics & numerical data   MeSH
• Adult MeSH
• Incidence MeSH
• Cohort Studies MeSH
• Middle Aged MeSH
• Humans MeSH
• Lung Diseases * epidemiology   etiology   MeSH
• Postoperative Complications * epidemiology   etiology   MeSH
• Risk Factors MeSH
• Aged MeSH
• Sex Factors MeSH
• Propensity Score MeSH
• Respiration, Artificial statistics & numerical data   MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Multicenter Study MeSH
• Observational Study MeSH

PURPOSE: The significance of dental status and oral hygiene on a range of medical conditions is well-recognised. However, the correlation between periodontitis, oral bacterial dysbiosis and visceral surgical outcomes is less well established. To this end, we study sought to determine the influence of dental health and oral hygiene on the rates of postoperative complications following major visceral and transplant surgery in an exploratory, single-center, retrospective, non-interventional study. METHODS: Our retrospective non-interventional study was conducted at the Department of General, Visceral, and Transplant Surgery, University Hospital Heidelberg, Germany. Patients operated on between January 2018 and December 2019 were retrospectively enrolled in the study based on inclusion (minimum age of 18 years, surgery at our Department, intensive care / IMC treatment after major surgery, availability of patient-specific preoperative dental status assessment, documentation of postoperative complications) and exclusion criteria (minor patients or legally incapacitated patients, lack of intensive care or intermediate care (IMC) monitoring, incomplete documentation of preoperative dental status, intestinal surgery with potential intraoperative contamination of the site by intestinal microbes, pre-existing preoperative infection, absence of data regarding the primary endpoints of the study). The primary study endpoint was the incidence of postoperative complications. Secondary study endpoints were: 30-day mortality, length of hospital stay, duration of intensive care stay, Incidence of infectious complications, the microbial spectrum of infectious complication. A bacteriology examination was added whenever possible (if and only if the examination was safe for the patient)for infectious complications. RESULTS: The final patient cohort consisted of 417 patients. While dental status did not show an influence (p = 0.73) on postoperative complications, BMI (p = 0.035), age (p = 0.049) and quick (p = 0.033) were shown to be significant prognostic factors. There was significant association between oral health and the rate of infectious complications for all surgical procedures (p = 0.034), excluding transplant surgery. However, this did not result in increased 30-day mortality rates, prolonged intensive care unit treatment or an increase in the length of hospital stay (LOS) for the cohort as a whole. In contrast there was a significant correlation between the presence of oral pathogens and postoperative complications for a group as a whole (p < 0.001) and the visceral surgery subgroup (p < 0.001). Whilst this was not the case in the cohort who underwent transplant surgery, there was a correlation between oral health and LOS in this subgroup (p = 0.040). Bacterial swabs supports the link between poor oral health and infectious morbidity. CONCLUSIONS: Dental status was a significant predictor of postoperative infectious complications in this visceral surgery cohort. This study highlights the importance preoperative dental assessment and treatment prior to major surgery, particularly in the case of elective surgical procedures. Further research is required to determine the effect of oral health on surgical outcomes in order to inform future practice. TRIAL REGISTRATION: Trial registered under the ethics-number S-082/2022 (Ethic Committee of the University Heidelberg).

• MeSH
• Length of Stay statistics & numerical data   MeSH
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Oral Hygiene MeSH
• Oral Health MeSH
• Postoperative Complications * epidemiology   etiology   MeSH
• Retrospective Studies MeSH
• Aged MeSH
• Organ Transplantation adverse effects   MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Observational Study MeSH
• Geographicals
• Germany MeSH

BACKGROUND: Proximal femoral fractures are severe injuries in geriatric patients. Additionally, geriatric patients are at a high risk of death due to coronavirus disease 2019 (COVID-19). OBJECTIVE: To identify predictors of mortality in geriatric patients with COVID-19 and concurrent proximal femoral fractures. MATERIAL AND METHODS: Patients who underwent surgical treatment for proximal femoral fractures and also tested positive for COVID-19 were included. The age, gender, the American Society of Anesthesiology (ASA) score and the admission from a nursing home were considered as variables. The rate of reoperations, the mortality at 3 months and discharge home were evaluated as outcomes. RESULTS: In this study 46 patients with COVID-19 (female/male 31/15, median age 87.0 years with an interquartile range [IQR] of 9.8 years) met the inclusion criteria. Of these, 32 patients (69.6%) had to be cared for in the intensive care unit and 26 patients (56.5%) had a severe course of COVID-19 with pneumonia. The median length of hospital stay for survivors was 19 (IQR 17.5) days and 4 of the patients (8.7%) required surgical revision. The in-hospital and 3‐month mortality were 40.0% (n = 17) and 43.5% (n = 20), respectively. The factors which influenced the in-hospital and 3‐month mortality rates were admission from a nursing home, the presence of pneumonia (increased the risk of death) and female gender (protective). CONCLUSION: The occurrence of COVID-19 in patients with proximal femoral fractures has a high mortality. Admission from a nursing home and the presence of pneumonia increased the risk of death, whereas women were at lower risk.

• MeSH
• COVID-19 * mortality   MeSH
• Length of Stay statistics & numerical data   MeSH
• Femoral Fractures mortality   surgery   MeSH
• Hip Fractures mortality   surgery   MeSH
• Proximal Femoral Fractures MeSH
• Humans MeSH
• Hospital Mortality MeSH
• Nursing Homes * statistics & numerical data   MeSH
• Reoperation statistics & numerical data   MeSH
• Retrospective Studies MeSH
• Risk Factors MeSH
• SARS-CoV-2 MeSH
• Aged, 80 and over MeSH
• Aged MeSH
• Check Tag
• Humans MeSH
• Male MeSH
• Aged, 80 and over MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Geographicals
• Germany MeSH

BACKGROUND AND AIMS: There is significant potential to streamline the clinical pathway for patients undergoing transcatheter aortic valve implantation (TAVI). The purpose of this study was to evaluate the effect of implementing BENCHMARK best practices on the efficiency and safety of TAVI in 28 sites in 7 European countries. METHODS: This was a study of patients with severe symptomatic aortic stenosis (AS) undergoing TAVI with balloon-expandable valves before and after implementation of BENCHMARK best practices. Principal objectives were to reduce hospital length of stay (LoS) and duration of intensive care stay. Secondary objective was to document patient safety. RESULTS: Between January 2020 and March 2023, 897 patients were documented prior to and 1491 patients after the implementation of BENCHMARK practices. Patient characteristics were consistent with a known older TAVI population and only minor differences. Mean LoS was reduced from 7.7 ± 7.0 to 5.8 ± 5.6 days (median 6 vs. 4 days; P < .001). Duration of intensive care was reduced from 1.8 to 1.3 days (median 1.1 vs. 0.9 days; P < .001). Adoption of peri-procedure best practices led to increased use of local anaesthesia (96.1% vs. 84.3%; P < .001) and decreased procedure (median 47 vs. 60 min; P < .001) and intervention times (85 vs. 95 min; P < .001). Thirty-day patient safety did not appear to be compromised with no differences in all-cause mortality (0.6% in both groups combined), stroke/transient ischaemic attack (1.4%), life-threatening bleeding (1.3%), stage 2/3 acute kidney injury (0.7%), and valve-related readmission (1.2%). CONCLUSIONS: Broad implementation of BENCHMARK practices contributes to improving efficiency of TAVI pathway reducing LoS and costs without compromising patient safety.

• MeSH
• Aortic Valve Stenosis * surgery   MeSH
• Benchmarking * MeSH
• Patient Safety MeSH
• Length of Stay * statistics & numerical data   MeSH
• Critical Pathways MeSH
• Humans MeSH
• Postoperative Complications epidemiology   prevention & control   MeSH
• Aged, 80 and over MeSH
• Aged MeSH
• Transcatheter Aortic Valve Replacement * methods   MeSH
• Check Tag
• Humans MeSH
• Male MeSH
• Aged, 80 and over MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Multicenter Study MeSH
• Geographicals
• Europe MeSH

PURPOSE: To describe temporal trends in inpatient care use for adult mental disorders in Czechia from 1994 until 2015. METHODS: Data from the nationwide register of inpatient care use and yearly census data were used to calculate (a) yearly admissions rates, (b) median length of stay, and (c) standardized inpatient-years for adult mental disorders (ICD-10 codes F0-F6] or G30). Segmented regressions were used to analyze age- and sex-specific temporal trends. RESULTS: Admission rates were increasing in adults (average annual percent change = 0.51; 95% confidence interval = 0.16 to 0.86 for females and 1.01; 0.63 to 1.40 for males) and adolescents and emerging adults (3.27; 2.57 to 3.97 for females and 2.98; 2.08 to 3.88 for males), whereas in seniors, the trend was stable (1.22; -0.31 to 2.73 for females and 1.35; -0.30 to 2.98 for males). The median length of stay for studied mental disorders decreased across all age and sex strata except for a stable trend in male adolescents and emerging adults (-0.96; -2.02 to 0.10). Standardized inpatient-years were decreasing in adults of both sexes (-0.85; -1.42 to -0.28 for females and -0.87; -1.19 to -0.56 for males), increasing in female adolescents and emerging adults (0.95; 0.42 to 1.47), and stable in the remaining strata. CONCLUSION: Psychiatric hospital admissions were increasing or stable coupled with considerable reductions in median length of stay, suggesting that inpatient episodes for adult mental disorders have become more frequent and shorter over time. The overall psychiatric inpatient care use was decreasing or stable in adults and seniors, potentially implying a gradual shift away from hospital-based care.

• MeSH
• Length of Stay * statistics & numerical data   MeSH
• Adult MeSH
• Mental Disorders * therapy   epidemiology   MeSH
• Hospitalization * statistics & numerical data   trends   MeSH
• Inpatients * statistics & numerical data   MeSH
• Middle Aged MeSH
• Humans MeSH
• Adolescent MeSH
• Young Adult MeSH
• Patient Admission statistics & numerical data   trends   MeSH
• Registries * MeSH
• Aged MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Adolescent MeSH
• Young Adult MeSH
• Male MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Geographicals
• Czech Republic MeSH

OBJECTIVE: Our research was focused to find a relation between the occurrence of spondylodiscitis and occurrence of chronic diseases. We were trying to discover some new risk factors and relations between chronic disorders in our research group. This analysis was also focused to detect factors that prolong the hospitalization of patients and worsen their prognosis. METHODS: A study was carried out involving patients with spondylodiscitis treated between 2013 and 2022. A statistical analysis expressed by several coefficients was calculated in software IBM SPSS 21. RESULTS: The study group comprised 32 (53.3%) females and 28 (46.7%) males. During the period the overall incidence of spondylodiscitis was increasing (except the year 2020 where only 2 patients were treated) with a peak in 2019. The average age of patients was 69.3 (±12.3) years, and the highest incidence was in the age group 60-69 years (n = 19, 31.7%). The most impacted vertebral region was lumbar (n = 29, 48.3%). The most prevalent associated comorbidity was some cardiovascular disorder (n = 39, 65%) followed by diabetes mellitus (DM) (n = 23, 38.3%). Genitourinary system was the most common source of primary infection (n = 22, 36.7%). Average length of stay was 34.3 (±14.5) days and surgery prolonged hospitalization period. Mortality rate was 1.7%. CONCLUSION: The results of our study are confirmed by the data of other European and non-European studies. We confirmed diabetes mellitus and hypertension as the most common non-infectious risk factors of spondylodiscitis and the presence of pathogens in genitourinary system as the most frequent source of primary infection.

• MeSH
• Chronic Disease epidemiology   MeSH
• Length of Stay statistics & numerical data   MeSH
• Discitis * epidemiology   MeSH
• Adult MeSH
• Incidence MeSH
• Comorbidity MeSH
• Middle Aged MeSH
• Humans MeSH
• Risk Factors MeSH
• Aged, 80 and over MeSH
• Aged MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Aged, 80 and over MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH

Cíl: Výkon ústavního ochranného léčení (OL) je vykonáván psychiatrickými nemocnicemi s regionální odpovědností. Cílem šetření / současného výzkumu je zmapovat a popsat populaci nemocných ve výkonu ochranného léčení, prezentovat data o nařízených OL, počtech nemocných v jednotlivých nemocnicích a ošetřovací době. Materiál a metoda: V rámci projektu "Deinstitucionalizace služeb pro duševně nemocné" probíhá pravidelný sběr dat, jehož součástí jsou i data nemocných s nařízeným OL. Další data byla získána z Centrální evidence statistických listů a výkaznictví (CSLAV) vedené Ministerstvem spravedlnosti ČR. Výsledky: Ke konci roku 2020 bylo za účelem výkonu OL hospitalizováno 839 pacientů, (82 žen a 757 mužů). V přepočtu na 100 000 obyvatel spádové oblasti existuje značná rozdílnost počtu nemocných, která mezi nemocnicemi kolísá v rozmezí 3-24 nemocných. Celostátní průměrná ošetřovací doba ústavních OL je 2, 6 roku, kdy mezi nemocnicemi jsou také značné rozdíly, a ošetřovací doba se pohybuje v rozmezí od několika měsíců po 6 let. Nejvyšší počet nemocných ve výkonu ústavního OL je z Karlovarského, Ústeckého a Moravskoslezského kraje. V diagnostickém složení se ukazuje nejvyšší podíl nemocných z okruhu psychotických poruch (F2) 47 %, 17 % nemocných je z okruhu F62-F69, který zahrnuje i parafilní poruchy, 16 % má diagnózu z okruhu F10-F19, tedy poruchy způsobené užíváním psychoaktivních látek. Závěr: V mezinárodním srovnání lze počet nemocných umístit do nižšího průměru evropských zemí, průměr ošetřovací doby se také jeví být v nižším průměru. Struktura a podrobnost dat z pravidelných cenzů neumožňují podrobnější popis populace z pohledu jejich rizikovosti pro společnost či spáchaného jednání.

Objective: Psychiatric hospitals with designated catchment areas are responsible for inpatient forensic treatment. We aim to present descriptive data concerning the inpatient forensic treatment population, patient numbers in hospitals, and treatment lengths. Method: As a part of the "Deinstitutionalization of Services for the Mentally Ill" project, regular data collection is performed, including collection of data on patients with a sentenced forensic treatment. Further data were obtained from the Central Register of Statistical Sheets and Reporting (CSLAV) kept by the Ministry of Justice of the Czech Republic. Results: The number of forensic patients at the end of the year 2020 was 839 (82 women and 757 men). There is a difference in patients ́ numbers in terms of 100,000 inhabitants of the catchment area, which varies between hospitals between 3 up to 24 patients. The national average treatment length of inpatient forensic treatment is 2.6 years, but there are differences between hospitals, and the treatment length varies from several months up to six years. The highest number of patients in inpatient forensic treatment is from regions: Karlovy Vary, Ústí nad Labem and Moravian-Silesian region. The diagnostic spectrum shows that the highest proportion of patients are diagnosed with psychotic disorders F2; (47%), 17% of patients are diagnosed with F62-F69 disorders, which also include paraphilic disorders, 16% have as the main diagnosis substance abuse; F10-F19. Conclusion: In an international comparison, patient numbers seem to be lower than in other European countries; the average treatment length also appears to be lower. The data structure from regular censuses has certain limitations as they do not allow a more detailed description of the population regarding risk for the society or the conduct committed.

• Keywords
• ochranné léčení,
• MeSH
• Length of Stay statistics & numerical data   MeSH
• Hospitalization statistics & numerical data   MeSH
• Humans MeSH
• Residential Treatment * statistics & numerical data   MeSH
• Hospitals, Psychiatric MeSH
• Exposure to Violence MeSH
• Check Tag
• Humans MeSH
• Publication type
• Research Support, Non-U.S. Gov't MeSH
• Geographicals
• Czech Republic MeSH

• MeSH
• COVID-19 * psychology   MeSH
• Length of Stay statistics & numerical data   MeSH
• Hospitalization statistics & numerical data   MeSH
• Community Mental Health Centers statistics & numerical data   MeSH
• Humans MeSH
• Hospital Bed Capacity statistics & numerical data   MeSH
• Psychiatric Department, Hospital organization & administration   statistics & numerical data   trends   MeSH
• Mental Health Services * organization & administration   statistics & numerical data   trends   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Newspaper Article MeSH