• MeSH
• Lymphoma, B-Cell * diagnosis   drug therapy   complications   MeSH
• Chlorambucil administration & dosage   adverse effects   therapeutic use   MeSH
• Molecular Targeted Therapy methods   trends   utilization   MeSH
• Cytogenetic Analysis methods   trends   utilization   MeSH
• Molecular Diagnostic Techniques methods   trends   utilization   MeSH
• Antibodies, Monoclonal, Humanized administration & dosage   adverse effects   therapeutic use   MeSH
• Drug Therapy, Combination * methods   utilization   MeSH
• Comorbidity * MeSH
• Quality of Life MeSH
• Humans MeSH
• Aged MeSH
• Check Tag
• Humans MeSH
• Male MeSH
• Aged MeSH
• Publication type
• Case Reports MeSH

Carneyho triáda je popsána jako synchronní nebo metachronní výskyt gastrointestinálního stromálního tumoru (GIST) žaludku, plicního chondromu a extraadrenálního paragangliomu. U většiny pacientů je vyjádřena pouze jedna nebo dvě komponenty. Současná koincidence všech tří nádorů v době diagnózy byla zaznamenána pouze přibližně ve 2 % případů. Nejčastější je kombinace GIST a plicního chondromu. Tímto sdělením chceme prezentovat případ 57leté pacientky s anamnézou prodělané resekce žaludku pro leiomyosarkom v mládí a nejasným ložiskovým plicním nálezem, který je stacionární minimálně od roku 2003. Pacientka měla v době první návštěvy u nás zjištěn blíže nespecifikovaný nádor žaludku, levého retroperitonea a dvě jaterní metastázy. Během dvou operací byla provedena exstirpace tumoru retroperitonea, klínovitá resekce žaludku, levostranná hemihepatektomie a adrenalektomie. Histologicky byl zjištěn GIST žaludku, jeho metastázy v játrech a feochromocytom/paragangliom levého retroperitonea. Nález svědčil pro diagnózu Carneyho trias nebo syndromu Carney-Stratakis. Provedením mutační analýzy genů kódujících B, C a D podjednotky enzymu sukcinátdehydrogenázy a potvrzením přítomnosti DNA metylace promotoru genu SDHC bylo zjištěno, že u pacientky se jedná o Carneyho trias a plicní nález bylo možné prohlásit za benigní chondrom. Tímto sdělením chceme poukázat na obtížnosti se stanovením diagnózy tohoto extrémně vzácného syndromu a jeho odlišení od syndromu Carney-Stratakis.

Carney triad is a synchronous or metachronous association of gastric gastrointestinal stromal tumors (GIST), pulmonary chondroma and extra-adrenal paraganglioma. The majority of patients have only one or two components of the triad, all three tumors being found in only about 2% of the patients at the time of the first diagnosis. The most common combination is gastric and pulmonary tumors. We report a case of Carney triad which was diagnosed at Masaryk Memorial Cancer Institute. A 57-year-old female patient with a history of gastric resection for leiomyosarcoma at the age of 14 and with an unclear pulmonary lesion evident on chest X-ray since as early as 2003. She was referred to our Clinic of Comprehensive Cancer Care after being diagnosed with unspecified tumors of the stomach, the left retroperitoneum and two liver metastases. Biopsy of the retroperitoneal mass was performed and histological examination showed pheochromocytoma. The patient underwent resection of the retroperitoneal tumor and wedge resection of the gastric tumor, left hemihepatectomy and left adrenalectomy (in two separate operations). The excised gastric tumor was a gastrointestinal stromal tumor (GIST) with a low risk of malignancy. Analysis of a liver specimen, however, showed two GIST metastases. No pathology was found in the left adrenal gland and the retroperitoneal tumor was positive for chromogranin A. Paraganglioma was thus diagnosed. Subsequently, mutational analysis of genes coding for succinate dehydrogenase subunits B, C and D (SDHB, SDHC, SDHD) and analysis of DNA methylation at the gene locus of SDHC was made. Carney triad was thus confirmed and the unclear pulmonary lesion could be described as benign chondroma. This report demonstrates the difficulty in distinguishing between Carney triad and Carney-Stratakis syndrome. Molecular information should improve the diagnosis of Carney triad.

• Keywords
• Carneyho trias, plicní chondrom, syndrom Carney-Stratakis, etraadrenální paraganglion,
• MeSH
• Chondroma diagnosis   MeSH
• Molecular Diagnostic Techniques methods   utilization   MeSH
• Diagnosis, Differential MeSH
• Middle Aged MeSH
• Humans MeSH
• Neoplasm Metastasis MeSH
• Lung Neoplasms diagnosis   MeSH
• Stomach Neoplasms * diagnosis   surgery   MeSH
• Tomography, X-Ray Computed utilization   MeSH
• Treatment Outcome MeSH
• Rare Diseases MeSH
• Check Tag
• Middle Aged MeSH
• Humans MeSH
• Female MeSH
• Publication type
• Case Reports MeSH
• Research Support, Non-U.S. Gov't MeSH

Cíl práce: Práce je zaměřena na možnosti diagnostiky pacientek s vulvovaginálním dyskomfortem i s důrazem na využití nekultivačních technik. Pozornost je věnována zejména významu hodnocení kvality poševního prostředí. Typ studie: Literární rešerše. Název a sídlo pracoviště: Porodnická a gynekologická klinika, Ústav klinické mikrobiologie, LF UK a FN Hradec Králové, Katedra biologických a lékařských věd, FAF UK Hradec Králové. Metodika: Analýza literárního přehledu a vlastních zkušeností s vyšetřením pacientek v poradně pro vulvovaginální dyskomfort.

Objective: Review of literature dealing with the specificity of the vagina from the standpoint of microbial colonization. Design: Literature review. Setting: Department of Obstetrics and Gynecology, Department of Clinical Microbiology, University Hospital and Medical Faculty in Hradec Kralove, Charles University Prague. Methods: Analysis of the literature review and personal experience dealing with vaginal microbiota.

• MeSH
• Molecular Diagnostic Techniques methods   utilization   MeSH
• Diagnostic Techniques, Obstetrical and Gynecological MeSH
• Gynecological Examination MeSH
• Humans MeSH
• Microscopy methods   utilization   MeSH
• Vulvovaginitis * diagnosis   MeSH
• Check Tag
• Humans MeSH
• Female MeSH
• Publication type
• Research Support, Non-U.S. Gov't MeSH

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study. The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for biomedical papers.

• Keywords
• velpatasvir, dasabuvir, ombitasvir, grazoprevir, daclatasvir,
• MeSH
• Medication Adherence MeSH
• Antiviral Agents * pharmacology   contraindications   therapeutic use   MeSH
• Hepatitis C, Chronic * diagnosis   drug therapy   prevention & control   MeSH
• Molecular Diagnostic Techniques methods   utilization   MeSH
• Heterocyclic Compounds, 4 or More Rings pharmacology   therapeutic use   MeSH
• Carbamates pharmacology   therapeutic use   MeSH
• Clinical Studies as Topic MeSH
• Clinical Laboratory Techniques MeSH
• Drug Therapy, Combination MeSH
• Comorbidity MeSH
• Humans MeSH
• Serologic Tests MeSH
• Simeprevir pharmacology   therapeutic use   MeSH
• Sofosbuvir pharmacology   therapeutic use   MeSH
• Drug Users MeSH
• Check Tag
• Humans MeSH
• Publication type
• Practice Guideline MeSH

• MeSH
• Bevacizumab therapeutic use   MeSH
• Quinazolines therapeutic use   MeSH
• Molecular Targeted Therapy * methods   trends   utilization   MeSH
• Molecular Diagnostic Techniques * methods   trends   utilization   MeSH
• ErbB Receptors genetics   isolation & purification   classification   MeSH
• Erlotinib Hydrochloride therapeutic use   MeSH
• Genetic Testing methods   trends   utilization   MeSH
• In Situ Hybridization, Fluorescence methods   utilization   MeSH
• Humans MeSH
• Mutation genetics   immunology   MeSH
• Lung Neoplasms * diagnosis   epidemiology   etiology   MeSH
• Pyrazoles therapeutic use   MeSH
• Pyrimidines therapeutic use   MeSH
• Risk Factors MeSH
• Aged MeSH
• Practice Guidelines as Topic MeSH
• Statistics as Topic MeSH
• Check Tag
• Humans MeSH
• Male MeSH
• Aged MeSH
• Publication type
• Case Reports MeSH

• MeSH
• Cdh1 Proteins genetics   immunology   isolation & purification   MeSH
• Digestive System Surgical Procedures methods   utilization   MeSH
• Molecular Targeted Therapy * methods   trends   utilization   MeSH
• Molecular Diagnostic Techniques * methods   utilization   MeSH
• Genetic Testing methods   utilization   MeSH
• Genes, erbB-2 genetics   immunology   MeSH
• Helicobacter pylori isolation & purification   pathogenicity   MeSH
• Antibodies, Monoclonal, Humanized therapeutic use   MeSH
• Immunotherapy methods   utilization   MeSH
• Middle Aged MeSH
• Humans MeSH
• Stomach Neoplasms * diagnosis   epidemiology   etiology   MeSH
• Antineoplastic Agents administration & dosage   classification   therapeutic use   MeSH
• Risk Factors MeSH
• Practice Guidelines as Topic MeSH
• Statistics as Topic MeSH
• Trastuzumab administration & dosage   therapeutic use   MeSH
• Check Tag
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Publication type
• Case Reports MeSH

• MeSH
• Molecular Targeted Therapy * methods   utilization   MeSH
• Molecular Diagnostic Techniques * methods   utilization   MeSH
• Adult MeSH
• Genetic Testing methods   utilization   MeSH
• Genes, ras genetics   immunology   radiation effects   MeSH
• Imidazoles therapeutic use   MeSH
• Combined Modality Therapy methods   utilization   MeSH
• Humans MeSH
• MAP Kinase Kinase Kinases antagonists & inhibitors   therapeutic use   MeSH
• Melanoma * diagnosis   epidemiology   etiology   MeSH
• Brain Neoplasms drug therapy   surgery   secondary   MeSH
• Oximes therapeutic use   MeSH
• Proto-Oncogene Proteins B-raf antagonists & inhibitors   therapeutic use   MeSH
• Risk Factors MeSH
• Practice Guidelines as Topic MeSH
• Statistics as Topic MeSH
• Ultraviolet Rays adverse effects   MeSH
• Check Tag
• Adult MeSH
• Humans MeSH
• Male MeSH
• Publication type
• Case Reports MeSH

• MeSH
• Bevacizumab therapeutic use   MeSH
• Molecular Targeted Therapy * methods   trends   utilization   MeSH
• Molecular Diagnostic Techniques * methods   utilization   MeSH
• Adult MeSH
• Everolimus therapeutic use   MeSH
• Gene Expression genetics   immunology   MeSH
• Phthalazines therapeutic use   MeSH
• Genes, erbB-2 genetics   immunology   MeSH
• Immunohistochemistry methods   utilization   MeSH
• Humans MeSH
• Tumor Suppressor Protein p53 isolation & purification   MeSH
• Breast Neoplasms * diagnosis   epidemiology   etiology   MeSH
• Poly(ADP-ribose) Polymerase Inhibitors therapeutic use   MeSH
• Aged MeSH
• Practice Guidelines as Topic standards   MeSH
• Statistics as Topic MeSH
• Trastuzumab therapeutic use   MeSH
• Check Tag
• Adult MeSH
• Humans MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Case Reports MeSH

• MeSH
• Digestive System Surgical Procedures methods   trends   utilization   MeSH
• Molecular Targeted Therapy methods   trends   utilization   MeSH
• Crohn Disease complications   MeSH
• Molecular Diagnostic Techniques * methods   utilization   MeSH
• Genetic Testing methods   utilization   MeSH
• Genes, ras genetics   immunology   MeSH
• Colorectal Neoplasms * diagnosis   epidemiology   etiology   MeSH
• Middle Aged MeSH
• Humans MeSH
• Antineoplastic Combined Chemotherapy Protocols therapeutic use   MeSH
• Proto-Oncogene Proteins B-raf genetics   immunology   isolation & purification   MeSH
• Risk Factors MeSH
• Aged MeSH
• Practice Guidelines as Topic MeSH
• Statistics as Topic MeSH
• Colitis, Ulcerative complications   MeSH
• Check Tag
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Case Reports MeSH

• MeSH
• Bevacizumab therapeutic use   MeSH
• Molecular Targeted Therapy * methods   trends   utilization   MeSH
• Molecular Diagnostic Techniques * methods   utilization   MeSH
• Immunotherapy methods   utilization   MeSH
• Indoles therapeutic use   MeSH
• Interferon-alpha therapeutic use   MeSH
• Interleukin-2 therapeutic use   MeSH
• Carcinoma, Renal Cell surgery   classification   therapy   MeSH
• Disease Attributes MeSH
• Middle Aged MeSH
• Humans MeSH
• Tumor Suppressor Protein p53 genetics   isolation & purification   MeSH
• Kidney Neoplasms * diagnosis   epidemiology   etiology   MeSH
• Risk Factors MeSH
• Aged MeSH
• Practice Guidelines as Topic MeSH
• Urologic Surgical Procedures methods   utilization   MeSH
• Check Tag
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Case Reports MeSH