Nová doporučení pro diagnostiku a léčbu chronických žilních onemocnění byla recentně publikována v časopise International Angiology, který je oficiálním časopisem společnosti International Union of Angiology (IUA). Dokument vznikl pod dohledem několika mezinárodních společností, tedy nejenom IUA, podílely se na něm i European Venous Forum, The Cardiovascular Disease Educational and Research Trust a Union Internationale de Phlebologie. Hlavním editorem těchto doporučení je Andrew Nicolaides. Celkově však podklady zpracovávalo více než 40 renomovaných autorů. Velmi obsažná je kapitola o patofyziologii chronických žilních chorob ve vztahu k léčebným farmakologickým možnostem. Netrpělivě byly očekávány závěry k léčbě venoaktivními léky, které jsou rozvedeny v kapitole 8, nejvíce důkazů o prospěchu nadále zjištěno u mikronizované purifikované flavonoidní frakce diosminu s hesperidinem. Ve zvláštních kapitolách je řešena otázka rozsahu nutných vyšetření pro přesnou detekci stavu žilních nemocí a problematika kompresivní léčby. Naopak nejsou probírány metody eliminace varixů.
New guidelines for diagnosing and treating chronic venous diseases have recently been published in the International Angiologyjournal which is the official journal of the International Union of Angiology (IUA). The document was created under the supervisionof several international societies, i.e. not only the IUA, but also involved were the European Venous Forum, the CardiovascularDisease Educational and Research Trust, and Union Internationale de Phlebologie. The main editor of these guidelines is AndrewNicolaides. Altogehter, they were prepared and developed by more than 40 renowned authors. Very comprehensive is the chapteron the pathophysiology of chronic venous diseases with respect to therapeutic pharmacological options. Conclusions on thetreatment with venoactive drugs dealt with in Chapter 8 have been eagerly awaited, with the most evidence of benefit havingbeen found for a micronized purified flavonoid fraction of diosmin with hesperidin. Special chapters address the issue of theextent of tests needed to precisely determine the status of venous disease, and that of compression therapy. On the other hand,methods for eliminating varices are not discussed.
- Keywords
- venofarmaka,
- MeSH
- Chronic Disease MeSH
- Diosmin therapeutic use MeSH
- Flavonoids pharmacology therapeutic use MeSH
- Phytotherapy MeSH
- Hesperidin therapeutic use MeSH
- Drug Therapy, Combination MeSH
- Humans MeSH
- Microcirculation drug effects MeSH
- Vascular Diseases * diagnosis etiology drug therapy physiopathology MeSH
- Risk Factors MeSH
- Plant Extracts classification therapeutic use MeSH
- Ruscus MeSH
- Practice Guidelines as Topic MeSH
- Varicose Veins MeSH
- Veins * physiopathology drug effects MeSH
- Venous Insufficiency MeSH
- Check Tag
- Humans MeSH
- Keywords
- ENERVIN,
- MeSH
- Camellia sinensis MeSH
- Cola MeSH
- Eleutherococcus MeSH
- Drug Combinations MeSH
- Phytotherapy * MeSH
- Ginkgo biloba MeSH
- Lepidium MeSH
- Neurasthenia * drug therapy MeSH
- Paullinia MeSH
- Plant Extracts classification therapeutic use MeSH
- Fatigue Syndrome, Chronic * drug therapy MeSH
- Panax MeSH
Benigní hyperplazie prostaty patří mezi nezhoubná, avšak, není-li léčeno, progredující onemocnění významně ovlivňující kvalitu života mužů již po 40. roce života. S věkem pak frekvence výskytu tohoto onemocnění narůstá. Článek si klade za cíl seznámit čtenáře s aktuálně dostupnými přípravky určenými k samoléčbě syndromu dolních močových cest, tedy klinicky vyjádřené symptomatologie benigní hyperplazie prostaty. Jedná se převážně o fytopreparáty obsahující nejčastěji extrakt z plodů trpasličí plevelné palmy Serenoa repens a nebo natě byliny Epilobium parviflorum, tedy vrbovky malokvěté. Kromě přehledu názvů volně prodejných preparátů, jejich složení a doporučeného dávkování je v článku uvedena krátká charakteristika vybraných složek fytopreparátů.
Benign prostatic hyperplasia belongs among benign, but if not treated, progressive disease significantly affecting the quality oflife of men after the 40th year of life. With age the incidence of this disease is increasing.Article aims to inform the reader with currently available products intended for self-medication of syndrome of the lower urinarytract, thus clinically expressed symptoms of benign prostatic hyperplasia. These are mainly phytopharmaceuticals containingmostly extract from the fruit of the weed dwarf palm Serenoa repens.In addition to the list of trade names of OTC preparations, their composition and recommended dosages, the article containsa brief description of selected components of pharmaceuticals.
- MeSH
- Phytotherapy MeSH
- Prostatic Hyperplasia * diagnosis drug therapy prevention & control MeSH
- Pharmaceutical Preparations analysis administration & dosage MeSH
- Plants, Medicinal classification MeSH
- Nonprescription Drugs * analysis administration & dosage classification MeSH
- Humans MeSH
- Dietary Supplements analysis classification MeSH
- Surveys and Questionnaires MeSH
- Plant Extracts administration & dosage classification MeSH
- Self Medication MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
Respirační infekce jsou jedno z nejčastějších infekčních onemocnění postihující jak děti, tak i dospělé. Nachlazení a chřipku léčíme převážně symptomaticky. Snížení teploty umožňují antipyretika, kašel ovlivňujeme dle jeho povahy antitusiky nebo expektorancii, k dekongesci nosní sliznice volíme sympatomimetika. Podpůrná léčba zahrnuje fytofarmaka s dezinfekčním, expektoračním, potopudným a nespecifickým imunomodulačním účinkem. Nezbytnou součástí léčby je klid na lůžku, dostatečné množství tekutin a lehká strava doplněná o vitaminy.
Respiratory infections are the most common infectious diseases which affect both children and adults. The treatment of cold and influenze is mostly symptomatical. Antipyretics are used to treat fever. Cought is affected by antitussives or expectorans according to character of cought. Sympatomimetics are used for decongestion of nasal mucosa. Supportive treatment includes phytopharmaceuticals with desinfectant, expectorant, hidrotic and non-specific immunomodulatory effects. Bed resting, sufficient fluid intake and vitamine-rich diet are essential parts of therapy.
- MeSH
- Analgesics pharmacology therapeutic use MeSH
- Anti-Infective Agents, Local pharmacology classification therapeutic use MeSH
- Antipyretics pharmacology therapeutic use MeSH
- Antitussive Agents pharmacology classification therapeutic use MeSH
- Aspirin pharmacology therapeutic use MeSH
- Influenza, Human * drug therapy MeSH
- Expectorants pharmacology therapeutic use MeSH
- Ibuprofen pharmacology therapeutic use MeSH
- Respiratory Tract Infections drug therapy MeSH
- Pharmaceutical Preparations MeSH
- Nonprescription Drugs MeSH
- Humans MeSH
- Common Cold * drug therapy MeSH
- Acetaminophen pharmacology therapeutic use MeSH
- Plant Extracts pharmacology classification therapeutic use MeSH
- Rhinitis MeSH
- Self Medication MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
Respirační infekce jsou jedno z nejčastějších infekčních onemocnění postihující jak děti, tak i dospělé. Nachlazení a chřipku léčíme převážně symptomaticky. Snížení teploty umožňují antipyretika, kašel ovlivňujeme dle jeho povahy antitusiky nebo expektorancii, k dekongesci nosní sliznice volíme sympatomimetika. Podpůrná léčba zahrnuje fytofarmaka s dezinfekčním, expektoračním, potopudným a nespecifickým imunomodulačním účinkem. Nezbytnou součástí léčby je klid na lůžku, dostatečné množství tekutin a lehká strava doplněná o vitaminy.
Respiratory infections are the most common infectious diseases which affect both children and adults. The treatment of coldand influenze is mostly symptomatical. Antipyretics are used to treat fever. Cought is affected by antitussives or expectoransaccording to character of cought. Sympatomimetics are used for decongestion of nasal mucosa. Supportive treatment includesphytopharmaceuticals with desinfectant, expectorant, hidrotic and non-specific immunomodulatory effects. Bed resting, sufficientfluid intake and vitamine-rich diet are essential parts of therapy.
- MeSH
- Analgesics pharmacology therapeutic use MeSH
- Anti-Infective Agents, Local pharmacology classification therapeutic use MeSH
- Antipyretics pharmacology therapeutic use MeSH
- Antitussive Agents pharmacology classification therapeutic use MeSH
- Aspirin pharmacology therapeutic use MeSH
- Influenza, Human * drug therapy MeSH
- Expectorants pharmacology therapeutic use MeSH
- Ibuprofen pharmacology therapeutic use MeSH
- Respiratory Tract Infections drug therapy MeSH
- Pharmaceutical Preparations MeSH
- Nonprescription Drugs MeSH
- Humans MeSH
- Common Cold * drug therapy MeSH
- Acetaminophen pharmacology therapeutic use MeSH
- Plant Extracts pharmacology classification therapeutic use MeSH
- Rhinitis MeSH
- Self Medication MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
Extrakty z rostlin jsou důležitým zdrojem většího počtu klinicky používaných protinádorových léčiv. Většina působí jako konvenční cytostatika modulující mikrotubuly (vinkristin, vinblastin, taxany), nebo inhibitory topoizomeráz jako např. deriváty epipodofylotoxinu a kamptotecinu (etopozid, irinotecan). Z rostlin či mořských organizmů jsou odvozeny také látky s účinkem na cílené nitrobuněčné struktury (flavopiridol, kombrestatin aj). Řada látek obsažených v ovoci a zelenině může interferovat z různými etapami kancerogeneze. Je uveden stručný přehled těchto chemopreventivních substancí.
Plant derived compounds have been an important source of many clinically useful anti-cancer agents. These include drugs acting as conventional cytostatics, such as microtubule modifiers (vincristin, vinblastin, taxanes), or topoisomerase inhibitors, such as epipodophyllotoxin and camptothecin derivatives (etoposid, irinotecan). From plant or marine organisms derived also drugs against cancer-related molecular targets (flavopiridol, combrestatin etc.), which are under clinical or preclinical development. Numerous phytochemicals derived from edible plants have been reported to interfere with a specific stage of the carcinogenic process. These chemopreventive phytochemicals are shortly reviewed.
- MeSH
- Anticarcinogenic Agents therapeutic use MeSH
- Chemoprevention * methods MeSH
- Cytostatic Agents therapeutic use MeSH
- Phytotherapy MeSH
- Topoisomerase Inhibitors therapeutic use MeSH
- Camptothecin therapeutic use MeSH
- Humans MeSH
- Microtubules drug effects MeSH
- Neoplasms * drug therapy MeSH
- Podophyllotoxin therapeutic use MeSH
- Antineoplastic Agents therapeutic use MeSH
- Plant Extracts * pharmacology classification therapeutic use MeSH
- Plants MeSH
- Taxoids therapeutic use MeSH
- Vinca Alkaloids therapeutic use MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
- MeSH
- Cholestenone 5 alpha-Reductase drug effects MeSH
- Phytotherapy * MeSH
- Prostatic Hyperplasia * epidemiology drug therapy therapy MeSH
- 5-alpha Reductase Inhibitors pharmacology therapeutic use MeSH
- Humans MeSH
- Meta-Analysis as Topic MeSH
- Plant Extracts classification therapeutic use MeSH
- Serenoa * chemistry MeSH
- Age Factors MeSH
- Treatment Outcome MeSH
- Check Tag
- Humans MeSH
- Male MeSH
In the current economic crisis, the use of plant medicine for cancer prevention should be investigated. Coix lachryma Linn and Asparagus cochinchinenesis Linn are among eleven of species of medicinal plants that are noted as plant medicine for cancer in Indonesia, although their mechanism of action are still unknown. The eleven plants were screened using in vitro methods, Sulforhodamin B against breast cancer cells (MCF-7) and skin (KB). The research included a maceration process using ethanol as solvent and an anti-cancer testing process in vitro using Sulforhodamin B indicated by the value of percentage viability. Extracts were classed as being 'active anticancer' if they showed IC50 values below 100 ppm.. Coix lachryma Linn. and Asparagus cochinchinenesis Linn. show breast and skin anticancer activity with IC50 values 6.51 ppm and 11.3 ppm of MCF-7 cells. The ethanol plant extracts were further extracted using various solvents with increasing polarity: n-hexane, methylene chloride, and ethyl acetate. The methylene chloride extract of Coix lachryma Linn. had IC50 = 2.75 ppm against MCF-7 cells. Against KB cells, methylene chloride extracts of Coix lachryma Linn. gave IC50 = 5.16 ppm. For Asparagus cochinchinenesis Linn., an ethyl acetate extract had IC50 = 3.70 ppm against KB cancer cells and IC50 = 9.80 ppm against MCF-7 cancer cells. These data indicated that both plants can be used as anticancer drugs on breast and skin cancers.
The paper discusses results of screening research made in vegetable extracts of Uzbekistan's flora in order to expose new, effective antiatherosclerotic drugs. The hypolipidemic feature in 106 vegetable extracts were researched in vivo mice with endogenous and ethanol hyperlipidemia with the definition of the content of overall cholesterol, triglycerides, general lipids and cholesterol lipoproteins in high concentration.
- Keywords
- in vivo,
- MeSH
- Hyperlipidemias * drug therapy chemically induced MeSH
- Disease Models, Animal MeSH
- Mice MeSH
- Plant Extracts * classification therapeutic use MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Animals MeSH
