OBJECTIVES: A marked asymmetry was previously reported in the sacral alae and S1-L5 facets orientation of the Neandertal individual Regourdou 1. Here, we provide a detailed description and quantification of the morphology and degree of asymmetry of this sacrum. MATERIAL AND METHODS: Regourdou 1 was compared to a modern human sample composed of 24 females and 17 males, and to other Neandertal individuals. Both traditional and geometric morphometric analyses were used in order to quantify the degree of sacral asymmetry of Regourdou 1. RESULTS: The asymmetry of both sacral alae and facets orientation substantially exceeds directional and absolute asymmetry of the healthy modern sample. Regourdou 1 shows a considerably shorter right ala, which is absolutely and relatively outside of the modern and Neandertal variations. CONCLUSION: Regourdou 1 shows marked sacral asymmetry that probably originated in early ontogenetic development. An asymmetric sacrum reflects asymmetric load dissipation and could relate to other morphological abnormalities observed in the skeleton, especially the mild scoliosis of the spine and the asymmetry of the femoral diaphyses. Further investigation is necessary to elucidate the relationship between those morphologies as well as a potential impact on the life of the individual.
- MeSH
- křížová kost abnormality MeSH
- neandertálci abnormality MeSH
- zkameněliny anatomie a histologie MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Francie MeSH
Autoři v kazuistickém sdělení popisují výskyt vzácné závažné kongenitální anomálie – syndromu kaudální regrese s jeho pozdní manifestací u dítěte s extrémně nízkou porodní hmotností. Neobvyklá je jak pozdní manifestace anomálie, tak výskyt u dítěte, které bez jiných závažných důsledků překonalo obtížné perinatální období. Klíčová slova: syndrom kaudální regrese, extrémně nízká porodní hmotnost
Authors presents the case report of rare congenital anomaly – caudal regression syndrome and his late manifestation in the extremely low birth weight infant. The unusual late manifestation of the anomaly in child who succesfully come through difficulty of perinatal period is described. Key words: caudal regression syndrome, extremely low birth weight
- Klíčová slova
- syndrom kaudální regrese,
- MeSH
- bederní obratle * abnormality radiografie MeSH
- fekální inkontinence * diagnóza etiologie vrozené MeSH
- inkontinence moči * diagnóza etiologie vrozené MeSH
- křížová kost * abnormality radiografie MeSH
- lidé MeSH
- magnetická rezonanční tomografie MeSH
- novorozenec s extrémně nízkou porodní hmotností MeSH
- novorozenec MeSH
- opožděná diagnóza MeSH
- předškolní dítě MeSH
- syndrom MeSH
- těhotenství při diabetu MeSH
- vrozené vady MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- novorozenec MeSH
- předškolní dítě MeSH
- Publikační typ
- kazuistiky MeSH
- práce podpořená grantem MeSH
Vertebral column pathologies requiring surgical intervention have been described in pet ferrets, however little information is available on the normal vertebral formula and congenital variants in this species. The purpose of this retrospective study was to describe vertebral formulas and prevalence of congenital vertebral anomalies in a sample of pet ferrets. Radiographs of 172 pet ferrets (96 males and 76 females) were included in this retrospective study. In 143 ferrets (83.14%), five different formulas of the vertebral column were recorded with normal morphology of vertebrae (rib attachment included) but with a variable number of thoracic (Th), lumbar (L), and sacral (S) vertebrae. The number of cervical (C) vertebrae was constant in all examined animals. Observed vertebral formulas were C7/Th14/L6/S3 (51.74%), C7/Th14/L6/S4 (22.10%), C7/Th14/L7/S3 (6.98%), C7/Th15/L6/S3 (1.74%), and C7/Th15/L6/S4 (0.58%). Formula C7/Th14/L6/S4 was significantly more common in males than in females (P < 0.05). Congenital spinal abnormalities were found in 29 ferrets (16.86%), mostly localized in the thoracolumbar and lumbosacral regions. The cervical region was affected in only one case. Transitional vertebrae represented the most common congenital abnormalities (26 ferrets) in the thoracolumbar (13 ferrets) and lumbosacral regions (10 ferrets) or simultaneously in both regions (three ferrets). Other vertebral anomalies included block (two ferrets) and wedge vertebra (one ferret). Spina bifida was not detected. Findings from the current study indicated that vertebral formulas may vary in ferrets and congenital abnormalities are common. This should be taken into consideration for surgical planning.
- MeSH
- bederní obratle abnormality anatomie a histologie MeSH
- fretky abnormality anatomie a histologie MeSH
- hrudní obratle abnormality anatomie a histologie MeSH
- krční obratle abnormality anatomie a histologie MeSH
- křížová kost abnormality anatomie a histologie MeSH
- páteř abnormality anatomie a histologie MeSH
- retrospektivní studie MeSH
- sexuální faktory MeSH
- žebra abnormality anatomie a histologie MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
Contrast fistulogram (FG) and distal pressure colostogram (DPCG) are standard diagnostic methods for the assessment of anorectal malformations. Pelvic magnetic resonance imaging (MRI) earned a place among essential diagnostic methods in preoperative investigations after the Currarino syndrome and a high incidence of associated spinal dysraphism were described. The aim of our study was to evaluate the possibility of substituting FG and DPCG by a modified pelvic MRI, e.g. MRI fistulogram (MRI-FG) and MRI colostogram (MRI-DPCG). The prospective study involved 29 patients with anorectal malformations who underwent a modified pelvic MRI. The length and course of fistulas and rectum, and the presence of sacral anomalies were studied on MRI images and compared with images obtained by radiologic examinations. Modified MRI brought identical results as contrast studies in 25 patients when related to the fistula and rectum length and course. MRI was more accurate for the detection of sacral anomalies. MRI-FG was the only imaging method used in the four most recent patients. The results support the assumption that conventional contrast examinations for the assessment of anorectal malformations can be replaced by MRI, thus reducing the radiation dose.
- MeSH
- anální kanál abnormality patologie MeSH
- celková anestezie MeSH
- kojenec MeSH
- kolostomie MeSH
- kontrastní látky aplikace a dávkování MeSH
- křížová kost abnormality MeSH
- lidé MeSH
- magnetická rezonanční tomografie metody MeSH
- mnohočetné abnormality MeSH
- močové píštěle vrozené diagnóza chirurgie MeSH
- nemoci anu vrozené diagnóza chirurgie MeSH
- nemoci močové trubice vrozené diagnóza chirurgie MeSH
- nemoci močového měchýře vrozené diagnóza chirurgie MeSH
- nemoci nedonošenců diagnóza chirurgie MeSH
- novorozenec nedonošený MeSH
- novorozenec s nízkou porodní hmotností MeSH
- novorozenec MeSH
- perineum patologie MeSH
- předoperační péče metody MeSH
- prospektivní studie MeSH
- rektální píštěl vrozené diagnóza chirurgie MeSH
- rektovaginální píštěl vrozené diagnóza chirurgie MeSH
- rektum abnormality patologie MeSH
- spina bifida diagnóza patologie MeSH
- střevní píštěle vrozené diagnóza chirurgie MeSH
- Check Tag
- kojenec MeSH
- lidé MeSH
- mužské pohlaví MeSH
- novorozenec MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky MeSH
- práce podpořená grantem MeSH
Congenital malformations such as lumbosacral transitional vertebrae and spina bifida occulta constitute unrare anomalies and could affect the symptomatology of low back pain. A transitional vertebra is characterized by elongation of one or both transverse processes, leading to the appearance ofa sacralized fifth lumbar vertebra or a lumbarized first sacral vertebra. Furthermore, sacral spina bifida occulta is a developmental anomaly that corresponds to the incomplete closure of the vertebral column. In the present case report, we describe a case of a dried sacrum presenting a partially sacralized fifth lumbar vertebra and total spina bifida, extended from first to fifth sacral vertebra. A pseudoarthrosis is formed on the left side and the specimen could be incorporated in Castellvi's type IIa. Moreover, the incidence, morphology, clinical and surgical significance of these spinal malformations are discussed.
- MeSH
- bederní obratle abnormality MeSH
- křížová kost abnormality MeSH
- lidé MeSH
- mrtvola MeSH
- spina bifida occulta patologie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
Caudal regression syndrome is a rare congenital condition characterized by varying degrees of developmental failure ranging from a partial sacral agenesis to the absence of lumbosarcal spine, hypoplasia, or fusion of the lower extremities and visceral anomalies. This is the third case of only one of the twins involved by this syndrome described in the literature and the second case of the selective involvement in dizygotic twins. Selective involvement of only one twin suggests that factors other than hyperglycemia and 7q deletions may be involved in the pathogenesis.
- MeSH
- abnormality trávicího systému genetika patologie MeSH
- anální kanál abnormality patologie MeSH
- dvojčata dizygotní MeSH
- křížová kost abnormality patologie MeSH
- lidé MeSH
- novorozenec MeSH
- rektum abnormality patologie MeSH
- syringomyelie genetika patologie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- novorozenec MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- studie na dvojčatech MeSH
- MeSH
- anální kanál abnormality MeSH
- genetická predispozice k nemoci MeSH
- komplikace těhotenství MeSH
- křížová kost abnormality MeSH
- lidé MeSH
- mnohočetné abnormality diagnóza genetika MeSH
- novorozenec MeSH
- rektum abnormality MeSH
- těhotenství MeSH
- Check Tag
- lidé MeSH
- novorozenec MeSH
- těhotenství MeSH
- Publikační typ
- kazuistiky MeSH
- MeSH
- bederní obratle abnormality MeSH
- dítě MeSH
- kostrč abnormality MeSH
- křížová kost abnormality MeSH
- lidé MeSH
- novorozenec MeSH
- prenatální diagnóza MeSH
- syndrom diagnóza MeSH
- vývojové onemocnění kostí MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- novorozenec MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
- MeSH
- křížová kost abnormality embryologie MeSH
- lidé MeSH
- Check Tag
- lidé MeSH
