We report a case of a 65-year-old man who developed an acute illness with fever, arthralgia and nephritic syndrome. Antinuclear antibodies were slightly positive and complement levels were low. Renal biopsy showed exudative diffuse proliferative endocapillary glomerulonephritis with diffuse immunoglobulin (IgG, IgA, IgM) and complement deposition (C3d, C4d, C1q) on immunofluorescence. The patient was first treated with corticosteroids and mycophenolate mofetil for suspected lupus with WHO class IV glomerulonephritis. The diagnosis was questioned and a diagnosis of parvovirus B19-associated nephritis was made based on elevation of serum IgM antibodies for parvovirus B19 and detection of parvovirus B19 DNA on renal biopsy. The immunosuppressive treatment was stopped and progressive spontaneous regression of clinical and laboratory abnormalities was observed. We conclude that human parvovirus B19 infection should be considered as a cause of lupus-like symptomatology and acute glomerulonephritis.

• MeSH
• akutní nemoc MeSH
• autoimunitní nemoci * MeSH
• biopsie MeSH
• DNA virů analýza   MeSH
• glomerulonefritida farmakoterapie   imunologie   virologie   MeSH
• glomerulus diagnostické zobrazování   MeSH
• imunosupresiva terapeutické užití   MeSH
• infekce viry z čeledi Parvoviridae MeSH
• lidé MeSH
• lidský parvovirus B19 izolace a purifikace   MeSH
• senioři MeSH
• syndrom MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH