- MeSH
- dítě MeSH
- hemangiom klasifikace patologie MeSH
- lidé MeSH
- melanom klasifikace patologie MeSH
- nádory oka * chirurgie klasifikace patologie radioterapie terapie MeSH
- oftalmologické chirurgické výkony klasifikace MeSH
- radioterapie klasifikace MeSH
- retinoblastom dějiny diagnóza farmakoterapie klasifikace patologie MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- Publikační typ
- přehledy MeSH
- MeSH
- hemangiom * diagnóza farmakoterapie patologie terapie MeSH
- kojenec MeSH
- laserová terapie MeSH
- lidé MeSH
- progrese nemoci MeSH
- propranolol * aplikace a dávkování MeSH
- recidiva MeSH
- ret patologie MeSH
- výsledek terapie MeSH
- Check Tag
- kojenec MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
Spindle cell hemangioma is a benign vascular tumor typically occurring in the dermis or subcutis of distal extremities as red-brown lesions that can grow in both size and number over time. They can be very painful and potentially disabling. A family history of cancer or previous history may be relevant and must be taken into consideration. Juxtaglomerular cell tumor (reninoma) is an extremely rare cause of secondary hypertension diagnosed mostly among adolescents and young adults. Excessive renin secretion results in secondary hyperaldosteronism. Subsequent hypokalemia and metabolic alkalosis, together with high blood pressure, are clues for clinical diagnosis. Histological examination of the excised tumor leads to a definitive diagnosis. Reninoma is found in subcapsular localization, in most cases as a solitary mass, in imaging studies of kidneys. Exceptionally, it can be located in another part of a kidney. Both spindle cell hemangioma and reninoma are extremely rare tumors in children and adolescents. Herein, the authors present a case report of a patient with hereditary BRCA1 interacting protein C-terminal helicase 1 (BRIP1) mutation, spindle cell hemangioma, and secondary hypertension caused by atypically localized reninoma.
- MeSH
- genetická predispozice k nemoci * MeSH
- hemangiom diagnóza genetika patologie MeSH
- juxtaglomerulární aparát patologie MeSH
- ledviny metabolismus patologie MeSH
- lidé MeSH
- proteiny FANC genetika MeSH
- RNA-helikasy genetika MeSH
- zárodečné mutace genetika MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- kazuistiky MeSH
- práce podpořená grantem MeSH
Pacientkou byla 61letá žena vyšetřená pro asi 10 let trvající tvorbu vícečetných, na dotek citlivých, červených projevů postihujícími pouze levou stranu krku. Přes opakované chirurgické excize a ošetření blíže neurčeným laserem projevy přibývaly. Histologicky byla stanovena diagnóza trsovitého („tufted“) hemangiomu. Autoři předkládají přehled současných znalostí o trsovitém hemangiomu a jeho diferenciální diagnostice.
The patient was a 61-year-old woman examined for occurrence of multiple, touch-sensitive, red manifestations affecting only the left side of her neck which started to develop about 10 years ago. Despite repeated surgical excisions and treatment with an unspecified laser, the num-ber of lesions was increasing. A diagnosis of tufted hemangioma was established on histology. The authors present an overview of current knowledge about tufted hemangioma and its differential diagnosis.
- MeSH
- hemangiom * diagnostické zobrazování patologie terapie MeSH
- inhibitory angiogeneze terapeutické užití MeSH
- interferon alfa aplikace a dávkování MeSH
- kyselina zoledronová analogy a deriváty škodlivé účinky terapeutické užití MeSH
- lidé MeSH
- protokoly antitumorózní kombinované chemoterapie MeSH
- thalidomid analogy a deriváty terapeutické užití MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
We report six cases of anastomosing hemangioma of the ovary. All lesions were unilateral and arose in 43 to 81 year old females. In all but one patient, the tumor was asymptomatic and represented incidental finding. The exception was a tumor associated with massive ascites and elevated CA 125. The tumors were, on cut section, spongy and dark violet in color. The size of tumors ranged from 0.5 to 3.5 cm. All lesions showed the same histological features and consisted of capillary sized anastomosing vessels with sinusoid-like pattern intermingled with sporadic medium sized vessels. Interestingly, in all cases there were areas of luteinized cells at the tumor periphery, which ranged from rare small nests to multiple and commonly confluent areas. In one tumor, components of mature adipose tissue were present. Immunohistochemically, all tumors were CD31 and CD34 positive. Other markers examined were negative, including; estrogen receptor, progesterone receptor, androgen receptor, and D2-40. Proliferative activity (Ki-67 index) was very low in all cases. Anastomosing hemangioma is a rare entity, only 8 lesions occurring in ovary has been described from its initial description in 2009. We report six additional cases with their clinicopathological correlation.
- MeSH
- dospělí MeSH
- hemangiom patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádorové biomarkery analýza MeSH
- nádory vaječníků patologie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
AIMS: Littoral cell angioma (LCA) is a rare primary splenic tumour that is frequently associated with internal malignancies. Immunohistochemistry can demonstrate a distinct hybrid endothelial-histiocytic phenotype of littoral cells, and is a helpful adjunct for making the correct diagnosis. The aims of this study were to present a series of 25 LCAs, with an emphasis on the frequent association of the neoplasm with visceral malignancies, and to provide a detailed immunohistochemical analysis by employing new markers. METHODS AND RESULTS: All 25 cases with available tissue blocks were immunohistochemically stained for endothelial and histiocytic markers. Clinical and follow-up data were retrieved from the respective institutions. The tumours were obtained from 16 males and nine females, whose age ranged from 32 to 86 years (mean 56.2 years). Clinical information was available for 24 of 25 patients, and follow-up for 11 of 25 patients (range 2-19 years; mean 11.6 years). Immunohistochemically, all cases were positive for LYVE-1, factor VIII, FLI-1, vascular endothelial growth factor receptor (VEGFR)-2, VEGFR-3, claudin-5, ERG, LMO2, CD31, CD163, lysozyme, and CD4, but negative for D2-40, CD8, and factor XIIIa. Fifteen of 25 cases were associated with various malignancies, including epithelial, mesenchymal and haematological tumours. CONCLUSIONS: The cohort of 25 patients is the largest series of LCAs published to date. By using antibodies against recently introduced endothelial markers, we have expanded the immunoprofile of LCA. We have further highlighted the clinical significance of LCA, as more than half of the patients in this study also harboured a coexisting visceral malignancy. Therefore, we conclude that the finding of splenic LCA mandates a thorough clinical evaluation for a concomitant malignancy.
- MeSH
- dospělí MeSH
- hemangiom patologie MeSH
- imunohistochemie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mnohočetné primární nádory patologie MeSH
- nádorové biomarkery analýza MeSH
- nádory sleziny patologie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- adjuvantní chemoterapie využití MeSH
- chirurgie operační MeSH
- dermatologie MeSH
- diferenciální diagnóza MeSH
- hemangiom * diagnóza epidemiologie etiologie farmakoterapie klasifikace patologie terapie MeSH
- interferon alfa aplikace a dávkování farmakologie terapeutické užití MeSH
- klinický obraz nemoci MeSH
- kojenec MeSH
- laserová terapie MeSH
- lidé MeSH
- nemocniční oddělení MeSH
- novorozenec MeSH
- patologická angiogeneze MeSH
- propranolol * aplikace a dávkování farmakologie kontraindikace škodlivé účinky terapeutické užití MeSH
- týmová péče o pacienty MeSH
- výsledek terapie MeSH
- Check Tag
- kojenec MeSH
- lidé MeSH
- mužské pohlaví MeSH
- novorozenec MeSH
- ženské pohlaví MeSH