BACKGROUND: Neurodegeneration with brain iron accumulation constitutes a group of rare progressive movement disorders sharing intellectual disability and neuroimaging findings as common denominators. Beta-propeller protein-associated neurodegeneration (BPAN) represents approximately 7% of the cases, and its first signs are typically epilepsy and developmental delay. We aimed to describe in detail the phenotype of BPAN with a special focus on iron metabolism. MATERIAL AND METHODS: We present a cohort of paediatric patients with pathogenic variants of WD-Repeat Domain 45 gene (WDR45). The diagnosis was established by targeted panel sequencing of genes associated with epileptic encephalopathies (n = 9) or by Sanger sequencing of WDR45 (n = 1). Data on clinical characteristics, molecular-genetic findings and other performed investigations were gathered from all participating centres. Markers of iron metabolism were analysed in 6 patients. RESULTS: Ten children (3 males, 7 females, median age 8.4 years) from five centres (Prague, Berlin, Vogtareuth, Tubingen and Cologne) were enrolled in the study. All patients manifested first symptoms (e.g. epilepsy, developmental delay) between 2 and 31 months (median 16 months). Seven patients were seizure-free (6 on antiepileptic medication, one drug-free) at the time of data collection. Neurological findings were non-specific with deep tendon hyperreflexia (n = 4) and orofacial dystonia (n = 3) being the most common. Soluble transferrin receptor/log ferritin ratio was elevated in 5/6 examined subjects; other parameters of iron metabolism were normal. CONCLUSION: Severity of epilepsy often gradually decreases in BPAN patients. Elevation of soluble transferrin receptor/log ferritin ratio could be another biochemical marker of the disease and should be explored by further studies.
- MeSH
- biologické markery krev MeSH
- dítě MeSH
- epilepsie krev genetika metabolismus MeSH
- fenotyp MeSH
- lidé MeSH
- mentální retardace krev genetika metabolismus MeSH
- neurodegenerativní nemoci krev genetika metabolismus MeSH
- pohybové poruchy krev genetika metabolismus MeSH
- poruchy metabolismu železa krev genetika metabolismus MeSH
- transportní proteiny genetika MeSH
- železo krev MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- experimenty na zvířatech MeSH
- hemokoagulace MeSH
- imobilizace MeSH
- králíci MeSH
- pohybové poruchy krev MeSH
- Check Tag
- králíci MeSH
- MeSH
- experimenty na zvířatech MeSH
- hemokoagulace MeSH
- imobilizace MeSH
- králíci MeSH
- pohybové poruchy krev MeSH
- Check Tag
- králíci MeSH