• MeSH
• Graves Disease * diagnosis   drug therapy   MeSH
• Weight Loss MeSH
• Hyperthyroidism diagnosis   drug therapy   MeSH
• Middle Aged MeSH
• Humans MeSH
• Methimazole administration & dosage   therapeutic use   MeSH
• Delayed Diagnosis MeSH
• Pyridoxine administration & dosage   therapeutic use   MeSH
• Antithyroid Agents MeSH
• Vitamin B Complex MeSH
• Vitamin D administration & dosage   therapeutic use   MeSH
• Check Tag
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Publication type
• Case Reports MeSH

• MeSH
• Dopamine Antagonists administration & dosage   therapeutic use   MeSH
• Anti-Allergic Agents administration & dosage   therapeutic use   MeSH
• Hyperemesis Gravidarum diet therapy   drug therapy   complications   physiopathology   MeSH
• Pregnancy Complications * MeSH
• Humans MeSH
• Nausea diet therapy   drug therapy   prevention & control   MeSH
• Pyridoxine administration & dosage   therapeutic use   MeSH
• Pregnancy MeSH
• Zingiber officinale MeSH
• Vomiting diet therapy   drug therapy   prevention & control   MeSH
• Check Tag
• Humans MeSH
• Pregnancy MeSH
• Female MeSH

LCIG je účinnou liečbou pokročilého štádia Parkinsonovej choroby. Jednou z obávaných komplikácii tejto liečby je polyneuropatia, ktorá môže zásadne ovplyvniť motorické aj non-motorické funkcie pacienta a kvalitu jeho života. Vo väčšine prípadov ide o metabolicky podmienenú polyneuropatiu v dôsledku užívania levodopy, a tým spojenej elevácie homocysteínu a deficitu vitamínov skupiny B. V prípade výskytu akútnej polyneuropatie je potrebné vylúčiť Guillainov-Barrého syndróm a ukončiť liečbu LCIG. U každého pacienta by sa malo myslieť na uvedenú komplikáciu, a to už pred zvažovanou indikáciou a následne aj počas celej doby liečby LCIG.

LCIG is an effective treatment for the advanced stage of Parkinson's disease. Serious complication of this treatment is polyneuropathy, which can signifficantly influenced motor and non-motor functions of the patient and the quality of life. In most of the cases there is a metabolic cause of polyneuropathy due to the usage of levodopa, associated with elevation of homocysteine and deficiency of vitamins B. In case of acute polyneuropathy, it is necessary to exclude Guillain-Barré Syndrome and discontinue LCIG treatment. Each patient should be examined for polyneuropathy before the initiation of LCIG therapy and also during the treatment.

• MeSH
• Diagnosis, Differential MeSH
• Drug Combinations MeSH
• Gels therapeutic use   MeSH
• Guillain-Barre Syndrome diagnosis   MeSH
• Homocysteine metabolism   MeSH
• Carbidopa therapeutic use   MeSH
• Levodopa therapeutic use   MeSH
• Humans MeSH
• Parkinson Disease drug therapy   complications   MeSH
• Polyneuropathies * chemically induced   diagnosis   drug therapy   classification   prevention & control   MeSH
• Pyridoxine administration & dosage   MeSH
• Vitamin B 12 administration & dosage   MeSH
• Vitamins metabolism   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Review MeSH

• MeSH
• Antitubercular Agents MeSH
• Antibiotics, Antitubercular MeSH
• Renal Insufficiency, Chronic * complications   MeSH
• Thorax diagnostic imaging   MeSH
• Isoniazid administration & dosage   therapeutic use   MeSH
• Humans MeSH
• Pyridoxine administration & dosage   therapeutic use   MeSH
• Rifampin administration & dosage   therapeutic use   MeSH
• Practice Guidelines as Topic MeSH
• Interferon-gamma Release Tests MeSH
• Tuberculosis * diagnosis   drug therapy   MeSH
• Vitamin B Complex MeSH
• Check Tag
• Humans MeSH

O vlivu vitaminů na lidský organismus bylo doposud napsáno nepřeberné množství článků, brožur a knih. Vzhledem k tomu, že některé publikace vydávají sami výrobci potravinových doplňků, jsou mnohdy psány tendenčně s cílem čtenáře přesvědčit o nezbytnosti užívání takovýchto přípravků a jejich odborná validita bývá často zkreslená. Pokud bychom se chtěli detailně zaobírat účinkem vitaminů, nestačilo by rozsahem ani celé číslo tohoto časopisu. V přehledném článku jsou proto poměrně stručně uvedena základní fakta, lékařům – urologům pro určité oživení, připomenutí, a vzhledem k tomu, že řada těchto látek má bezprostřední vliv i na urogenitální systém (vitaminy B6, C, D, E), je o těchto v článku pojednáno podrobněji.

Abundant literature has been published on the effect of vitamins on the human body. Given the fact that some of the publications are produced by the manufacturers of food supplements themselves, these are frequently written in a tendentious way in order to persuade the reader of the necessity of taking such products, and their scientific validity is often biased. If we wanted to address the effect of vitamins in detail, even the entire issue of this journal would not suffice. Therefore, the review article presents, in a relatively brief manner, the fundamental facts for you, doctors-urologists, as a kind of reminder; and since a number of these substances have a direct impact on the urogenital system (vitamins B6, C, D, E) as well, they are dealt with in more detail in the article.

• Keywords
• kyselina pantotenová,
• MeSH
• Avitaminosis physiopathology   pathology   MeSH
• Biotin MeSH
• Ascorbic Acid administration & dosage   pharmacology   MeSH
• Folic Acid administration & dosage   pharmacology   MeSH
• Humans MeSH
• Niacin administration & dosage   pharmacology   MeSH
• Food MeSH
• Pyridoxine administration & dosage   pharmacology   MeSH
• Riboflavin administration & dosage   pharmacology   MeSH
• Thiamine administration & dosage   pharmacology   MeSH
• Urogenital System MeSH
• Vitamin A administration & dosage   pharmacology   adverse effects   MeSH
• Vitamin B 12 administration & dosage   pharmacology   MeSH
• Vitamin B 6 administration & dosage   pharmacology   MeSH
• Vitamin D administration & dosage   pharmacology   adverse effects   MeSH
• Vitamin E administration & dosage   pharmacology   therapeutic use   MeSH
• Vitamin K administration & dosage   pharmacology   MeSH
• Vitamins * administration & dosage   classification   therapeutic use   MeSH
• Prescription Drug Misuse MeSH
• Check Tag
• Humans MeSH
• Publication type
• Review MeSH

• MeSH
• Homocysteine administration & dosage   metabolism   drug effects   MeSH
• Homocystinuria * diagnosis   diet therapy   metabolism   physiopathology   MeSH
• Humans MeSH
• Methionine administration & dosage   metabolism   standards   MeSH
• Adolescent MeSH
• Diet, Protein-Restricted standards   MeSH
• Pyridoxine administration & dosage   MeSH
• Amino Acid Metabolism, Inborn Errors MeSH
• Check Tag
• Humans MeSH
• Adolescent MeSH
• Female MeSH
• Publication type
• Case Reports MeSH

• MeSH
• Serotonin 5-HT1 Receptor Agonists administration & dosage   classification   therapeutic use   MeSH
• Cholinergic Agents administration & dosage   classification   therapeutic use   MeSH
• Clinical Trials as Topic MeSH
• Cognition physiology   drug effects   MeSH
• Humans MeSH
• Neurons metabolism   MeSH
• Nootropic Agents * administration & dosage   classification   therapeutic use   MeSH
• Dietary Supplements MeSH
• Pyridoxine analogs & derivatives   administration & dosage   therapeutic use   MeSH
• Check Tag
• Humans MeSH

Pyridoxin-dependentní epilepsie je autozomálně recesivně dědičné onemocnění, které se prenatálně, neonatálně a v časném dětství do 3 let projevuje farmakorezistentními epileptickými záchvaty. Jde o dědičné poruchy metabolizmu pyridoxinu asociované s mutacemi v genech ALDH7A1 nebo ALDH4A1. Podobným onemocněním je pyridoxal-fosfát dependentní epilepsie (neonatální epileptická encefalopatie) podmíněná mutacemi v PNPO genu. Pyridoxin-dependentní epilepsie jsou úspěšně léčitelné vysokými dávkami pyridoxinu. Pyridoxal-fosfát dependentní epilepsie jsou na terapii pyridoxinem refrakterní, ale reagují na léčbu pyridoxal-fosfátem. Diagnostika obou jednotek je založena na genetickém a biochemickém vyšetření.

Pyridoxine dependent epilepsy is a rare autosomal recessive hereditary disorder causing a severe intractable epileptic seizures presenting typically in prenatal and neonatal period, rarely in early infancy (age up to 3 years). Pyridoxine dependent epilepsy, caused by metabolic disturbance of pyridoxine, is associated with mutations in ALDH7A1 or ALDH4A1 gene. Similar condition, pyridoxal-phosphate dependent epilepsy (also called neonatal epileptic encephalopathy), is caused by mutations in PNPO gene. Pyridoxine dependent epilepsy is successfully treatable using high doses of pyridoxine. Neonatal epileptic encephalopathy is refractory to pyridoxine administration, however responses to treatment with pyridoxal-phosphate. The diagnosis of both pyridoxine dependent epilepsy and neonatal epileptic encephalopathy is based on biochemical and genetic examinations.

• Keywords
• pyridoxal-fosfát, neonatální epileptická encefalopatie,
• MeSH
• Aldehyde Dehydrogenase genetics   MeSH
• Molecular Diagnostic Techniques methods   utilization   MeSH
• Child MeSH
• Electroencephalography utilization   MeSH
• Humans MeSH
• Infant, Newborn, Diseases genetics   metabolism   MeSH
• Infant, Newborn MeSH
• Pyridoxal Phosphate administration & dosage   metabolism   MeSH
• Pyridoxine administration & dosage   metabolism   MeSH
• Vitamin B 6 administration & dosage   adverse effects   MeSH
• Seizures diagnosis   drug therapy   genetics   MeSH
• Check Tag
• Child MeSH
• Humans MeSH
• Infant, Newborn MeSH
• Publication type
• Review MeSH

Mezoterapie je technika injekčního zavádění účinných látek do mezodermu, tedy přibližně do hloubky 4mm. Mezodermem se rozumí podkoží spolu s tukovou tkání. Léčebné roztoky obsahují vysoké koncentrace vitaminů, aminokyselin a koenzymů. Slovo mezoterapie vzniklo složením dvou řeckých slov, mesos znamená střední a therapeia léčba.

• MeSH
• Aminophylline administration & dosage   pharmacology   MeSH
• Pain MeSH
• Dermatology methods   MeSH
• Phosphatidylcholines administration & dosage   pharmacology   MeSH
• Hyaluronoglucosaminidase administration & dosage   pharmacology   MeSH
• Cicatrix therapy   MeSH
• Carnitine administration & dosage   pharmacology   MeSH
• Cosmetic Techniques MeSH
• Ascorbic Acid administration & dosage   pharmacology   MeSH
• Hyaluronic Acid administration & dosage   pharmacology   MeSH
• Pantothenic Acid administration & dosage   pharmacology   MeSH
• Humans MeSH
• Lidocaine administration & dosage   pharmacology   MeSH
• Pain Management MeSH
• Mannitol administration & dosage   pharmacology   MeSH
• Melilotus MeSH
• Mesoderm drug effects   MeSH
• Pentoxifylline administration & dosage   pharmacology   MeSH
• Subcutaneous Fat drug effects   MeSH
• Procaine administration & dosage   pharmacology   MeSH
• Pyridoxine administration & dosage   pharmacology   MeSH
• Thiamine administration & dosage   pharmacology   MeSH
• Vitamin A administration & dosage   pharmacology   MeSH
• Vitamin B 12 administration & dosage   pharmacology   MeSH
• Vitamin E administration & dosage   pharmacology   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Review MeSH

• MeSH
• Diagnostic Techniques and Procedures MeSH
• Diagnosis MeSH
• Child MeSH
• Humans MeSH
• Microbiological Techniques methods   MeSH
• Adolescent MeSH
• Pediatrics MeSH
• Pyridoxine administration & dosage   therapeutic use   MeSH
• Tuberculosis etiology   therapy   MeSH
• Check Tag
• Child MeSH
• Humans MeSH
• Adolescent MeSH
• Publication type
• Case Reports MeSH