The renin angiotensin system is a key regulator of blood pressure homeostasis. Angiotensin type 1 (AT1R) and 2 receptors (AT2R) have been investigated as targets for cisplatin-induced acute kidney injury; however, their therapeutic potential remains inconclusive. This pilot study aimed to determined the effect that acute cisplatin treatment had on angiotensin II (AngII)-induced contraction in blood vessels and expression profiles of AT1R and AT2R in mouse arteries and kidneys. Male C57BL/6 mice at 18 week of age (n = 8) were treated with vehicle or bolus dose of cisplatin (12.5 mg/kg). Thoracic aorta (TA), adnominal aorta (AA), brachiocephalic arteries (BC), iliac arteries (IL) and kidneys were collected for isometric tension and immunohistochemistry analysis. Cisplatin treatment reduced IL contraction to AngII at all doses (p < 0.01, p < 0.001, p < 0.0001); however, AngII did not induce contraction in TA, AA or BC in either treatment group. Following cisplatin treatment, AT1R expression was significantly upregulated in the media of TA (p < 0.0001) and AA (p < 0.0001), and in the endothelium (p < 0.05) media (p < 0.0001) and adventitia (p < 0.01) of IL. Cisplatin treatment significantly reduced AT2R expression in the endothelium (p < 0.05) and media (p < 0.05) of TA. In renal tubules, both AT1R (p < 0.01) and AT2R (p < 0.05) were increased following cisplatin treatment. Herein, we report that cisplatin reduces AngII-mediated contraction in IL and may be explained by an absence of normal counterregulatory expression of AT1R and AT2R, indicating other factors are involved.

• MeSH
• angiotensin II * farmakologie   metabolismus   MeSH
• cisplatina * farmakologie   MeSH
• myši inbrední C57BL MeSH
• myši MeSH
• pilotní projekty MeSH
• receptor angiotensinu typ 1 metabolismus   MeSH
• receptor angiotensinu typ 2 metabolismus   MeSH
• zvířata MeSH
• Check Tag
• mužské pohlaví MeSH
• myši MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH

Coronavirus infections are frequent viral infections in several species. As soon as the severe acute respiratory syndrome (SARS) appeared in the early 2000s, most of the research focused on pulmonary disease. However, disorders in immune response and organ dysfunctions have been documented. Elderly individuals with comorbidities exhibit worse outcomes in all the coronavirus that cause SARS. Disease severity in SARS-CoV-2 infection is related to severe inflammation and tissue injury, and effective immune response against the virus is still under analysis. ACE2 receptor expression and polymorphism, age, gender and immune genetics are factors that also play an essential role in patients' clinical features and immune responses and have been partially discussed. The present report aims to review the physiopathology of SARS-CoV-2 infection and propose new research topics to understand the complex mechanisms of viral infection and viral clearance.

• MeSH
• angiotensin konvertující enzym 2 genetika   metabolismus   MeSH
• biologické markery MeSH
• COVID-19 komplikace   imunologie   metabolismus   virologie   MeSH
• cytokiny metabolismus   MeSH
• energetický metabolismus MeSH
• interakce hostitele a patogenu imunologie   MeSH
• lidé MeSH
• mediátory zánětu metabolismus   MeSH
• náchylnost k nemoci imunologie   MeSH
• podskupiny lymfocytů imunologie   metabolismus   MeSH
• přirozená imunita MeSH
• receptor angiotensinu typ 2 metabolismus   MeSH
• replikace viru MeSH
• SARS-CoV-2 fyziologie   MeSH
• syndrom uvolnění cytokinů etiologie   metabolismus   MeSH
• virové receptory metabolismus   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

The aim of this study was first to evaluate the effects of persistent or transient blockade of the angiotensin II (ANG II) receptor AT(1) on the development of hypertension and end-organ damage in hypertensive Ren-2 transgenic rats (TGR), and second to assess the potential role of AT(2) receptors in the control of blood pressure (BP) in this monogenetic model of hypertension. Male heterozygous TGR and Hannover Sprague-Dawley (HanSD) rats fed a normal salt diet were treated from day 32 of age either persistently until the end of the experiment (day 100 of age) or transiently until day 56 of age with the selective AT(1) receptor antagonist candesartan or with the combination of candesartan and the AT(2) receptor antagonist PD 123319. Persistent treatment with candesartan completely prevented the rise in BP, proteinuria and the increase in left ventricular weight/body weight ratio, whereas transient treatment with candesartan was effective only as long as the drug was administered. In the presence of candesartan, PD 123319 was without effect. Our results show that in male heterozygous TGR persistent candesartan treatment completely prevented hypertension and end-organ damage as long as the drug was administered, whereas transient AT(1 )receptor blockade had no long-term effects. Copyright 2007 S. Karger AG, Basel.

• MeSH
• benzimidazoly farmakologie   MeSH
• blokátory receptoru 1 pro angiotenzin II farmakologie   MeSH
• financování organizované MeSH
• geneticky modifikovaná zvířata MeSH
• krevní tlak MeSH
• krysa rodu rattus MeSH
• ledviny patofyziologie   MeSH
• potkani Sprague-Dawley MeSH
• proteinurie moč   MeSH
• receptor angiotensinu typ 1 metabolismus   MeSH
• receptor angiotensinu typ 2 fyziologie   krev   metabolismus   MeSH
• renální hypertenze farmakoterapie   MeSH
• renin genetika   MeSH
• tetrazoly farmakologie   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH

• MeSH
• angiotensin II antagonisté a inhibitory   MeSH
• antagonisté mineralokortikoidních receptorů farmakologie   metabolismus   terapeutické užití   MeSH
• arginin analogy a deriváty   biosyntéza   metabolismus   MeSH
• Aspirin farmakologie   metabolismus   terapeutické užití   MeSH
• estrogeny farmakologie   metabolismus   terapeutické užití   MeSH
• farmakoterapie metody   MeSH
• inhibitory ACE MeSH
• kyselina klofibrová analogy a deriváty   MeSH
• lidé MeSH
• receptor angiotensinu typ 2 metabolismus   terapeutické užití   MeSH
• statiny farmakologie   metabolismus   terapeutické užití   MeSH
• synthasa oxidu dusnatého antagonisté a inhibitory   MeSH
• thiazolidindiony farmakologie   metabolismus   terapeutické užití   MeSH
• Check Tag
• lidé MeSH

The presence of angiotensin II receptors was found on cells of three colorectal carcinoma cell lines. The binding assays with 125I-labelled angiotensin II and ligands specific for angiotensin AT1 or AT2 receptors showed that angiotensin receptors on colorectal cancer cells are mostly of the AT2 type. The binding capacity of tumor cells was not significantly changed by butyrate-induced differentiation.

• MeSH
• angiotensin II chemie   metabolismus   MeSH
• blokátory receptoru 1 pro angiotenzin II metabolismus   MeSH
• buněčná membrána metabolismus   MeSH
• financování organizované MeSH
• kolorektální nádory metabolismus   MeSH
• lidé MeSH
• losartan metabolismus   MeSH
• nádorové buněčné linie metabolismus   MeSH
• oligopeptidy metabolismus   MeSH
• radioizotopy jodu metabolismus   MeSH
• receptor angiotensinu typ 2 genetika   metabolismus   MeSH
• Check Tag
• lidé MeSH