• MeSH
• antagonisté bradykininového receptoru B2 aplikace a dávkování   farmakologie   MeSH
• diferenciální diagnóza MeSH
• hereditární angioedémy * epidemiologie   klasifikace   patofyziologie   terapie   MeSH
• injekce subkutánní trendy   MeSH
• lidé MeSH
• receptor bradykininu B2 metabolismus   účinky léků   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• novinové články MeSH

Bradykinin can enhance skeletal muscle glucose uptake (GU), and exercise increases both bradykinin production and muscle insulin sensitivity, but bradykinin's relationship with post-exercise insulin action is uncertain. Our primary aim was to determine if the B2 receptor of bradykinin (B2R) is essential for the post-exercise increase in GU by insulin-stimulated mouse soleus muscles. Wildtype (WT) and B2R knockout (B2RKO) mice were sedentary or performed 60 minutes of treadmill exercise. Isolated soleus muscles were incubated with [(3)H]-2-deoxyglucose +/-insulin (60 or 100 microU/ml). GU tended to be greater for WT vs. B2RKO soleus with 60 microU/ml insulin (P=0.166) and was significantly greater for muscles with 100 microU/ml insulin (P<0.05). Both genotypes had significant exercise-induced reductions (P<0.05) in glycemia and insulinemia, and the decrements for glucose (~14 %) and insulin (~55 %) were similar between genotypes. GU tended to be greater for exercised vs. sedentary soleus with 60 microU/ml insulin (P=0.063) and was significantly greater for muscles with 100 microU/ml insulin (P<0.05). There were no significant interactions between genotype and exercise for blood glucose, plasma insulin or GU. These results indicate that the B2R is not essential for the exercise-induced decrements in blood glucose or plasma insulin or for the post-exercise increase in GU by insulin-stimulated mouse soleus muscle.

• MeSH
• genotyp MeSH
• inzulin lidský farmakologie   krev   metabolismus   MeSH
• kondiční příprava zvířat MeSH
• kosterní svaly metabolismus   MeSH
• krevní glukóza metabolismus   MeSH
• lidé MeSH
• myši knockoutované MeSH
• myši MeSH
• receptor bradykininu B2 genetika   metabolismus   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• myši MeSH
• zvířata MeSH