The authors present two cases of severe atopic dermatitis with extremely elevated IgE levels treated with omalizumab. The effect of this treatment was completely unconvincing in both patients, most likely because of extremely elevated IgE values, which could not be eliminated by omalizumab. Our observation is consistent with earlier published literature reporting that omalizumab as a treatment for atopic dermatitis seems to work better in patients with lower levels of IgE antibodies.
- MeSH
- atopická dermatitida farmakoterapie imunologie MeSH
- dermatologické látky terapeutické užití MeSH
- dospělí MeSH
- imunoglobulin E imunologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- omalizumab terapeutické užití MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- přehledy MeSH
INTRODUCTION: Atopy patch tests (APT) represent a relatively new diagnostic method for identifying the role of airborne allergens in atopic dermatitis flares. This study evaluates the role of airborne allergens in atopic dermatitis flares in a group of adult patients with atopic dermatitis. The primary goal was to detect the frequency of sensitization to these allergens in a group of patients with atopic dermatitis by APT. The secondary goal was to compare the results of APT with specific IgE against the same airborne allergens with regard to sensitivity and specificity. METHODS: Between November 2004 and October 2011, a cohort of 125 patients (37 males and 88 females) with atopic dermatitis was investigated using APT at the 1st Department of Dermatovenereology of the St. Anne Faculty in Brno, Czech Republic. RESULTS: In 36 (28.8%) patients, the APT were positive, and in 89 (71.2%) negative. The most common allergens were house dust mite allergens (12.8%), followed by grass and plant pollen (10.4%) and dog allergens (8%). CONCLUSION: The results indicate that APT is a helpful tool for identifying airborne allergens as triggering factors of atopic dermatitis.
- MeSH
- alergeny diagnostické užití MeSH
- atopická dermatitida diagnóza epidemiologie imunologie MeSH
- dospělí MeSH
- hodnocení rizik MeSH
- incidence MeSH
- kohortové studie MeSH
- látky znečišťující vzduch diagnostické užití imunologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- náplasťové testy metody MeSH
- psi MeSH
- retrospektivní studie MeSH
- senzitivita a specificita MeSH
- stupeň závažnosti nemoci MeSH
- zvířata MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- psi MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Geografické názvy
- Česká republika MeSH
Segmental Darier's disease is a rare clinical variant of autosomal dominant Darier's disease (keratosis follicularis) exhibiting eruptions in a unilateral arrangement following the lines of Blaschko. It occurs in approximately 10% of patients with Darier's disease. We report two cases of type 1 segmental Darier's disease that appeared a few months after childbirth; in one case, recurrence of the disease occurred after tubal ligation.
- MeSH
- Darierova nemoc etiologie patologie MeSH
- dospělí MeSH
- kůže patologie MeSH
- lidé MeSH
- poruchy v puerperiu patologie MeSH
- recidiva MeSH
- těhotenství MeSH
- tubární sterilizace škodlivé účinky MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
BACKGROUND: Mycosis fungoides, or cutaneous T-cell lymphoma (CTCL), is one of the most common skin lymphomas, with a chronic and lethal course. It is characterized by the expansion of CD4+ and CDw29+ immunophenotype T-cell clones lacking normal antigens. These altered T-lymphocytes are predominantly located in the skin, but some of them retain their ability to migrate and exit the skin through the lymphatics into the circulatory system. CASE REPORT: We report on a 78-year-old man with an 8-year history of histologically verified Mycosis fungoides. Twenty-five years ago, the patient was incorrectly diagnosed with psoriasis vulgaris and received therapy with only slight effect. In 1999 the patient underwent full body actinotherapy (30 Gy) which resulted in complete remission of CTCL lesions on the skin. In October 2005 the patient presented at our department with a new partially infiltrated lesion 14x6 cm in his right groin. Because photochemotherapy and local therapy with corticosteroids had already been used without significant results, we opted for photodynamic therapy (PDT) with methyl aminolevulinate (MAL).
OBJECTIVE: 1) Assessment of the frequency of contact sensitization to selected excipients of dermatological topical preparations and cosmetics in patients with chronic eczema. 2) Detection of the sources of sensitization. METHODS: 1,927 patients with chronic eczema (mean age 44.3 years, 601 males, 1,326 females) were patch tested with selected excipients. RESULTS: The main rates of sensitization observed were: thiomersal 11.3%, wool alcohols 4.0%, phenylmercuric acetate 3.1%, formaldehyde 2.5%, dodecyl gallate 2.0%, Bronopol 1.9%, dibromodicyanobutane/ phenoxyethanol (1:4) 1.7%, chloracetamide 1.6%, chlorhexidine digluconate 1.5%, Kathon CG 1.4%, parabens 1.1%, diazolidinyl urea 0.9%, imidazolidinyl urea 0.7%, benzalkonium chloride 0.7%, and Quaternium-15 (quaternary ammonium salt) 0.7%. CONCLUSION: The rate of sensitization to the excipients included in dermatological topical preparations and cosmetics in patients with chronic eczema is significant. Complete information on all the ingredients is necessary.
- MeSH
- chronická nemoc MeSH
- dermatologické látky imunologie MeSH
- dospělí MeSH
- ekzém imunologie MeSH
- financování organizované MeSH
- formaldehyd imunologie MeSH
- kontaktní dermatitida imunologie MeSH
- konzervační prostředky farmaceutické škodlivé účinky MeSH
- kosmetické přípravky škodlivé účinky MeSH
- lidé MeSH
- parabeny škodlivé účinky MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
Granuloma eosinophilicum faciale (GF) is a rare chronic inflammatory disorder of unknown etiology. Although the condition is benign, its treatment is often unsatisfactory. We describe a case of a 60-year-old man with GF resistant to therapy with topical corticosteroids and liquid nitrogen. After 4 months of treatment with topical tacrolimus the lesions resolved, with remission lasting for 2 years.
- MeSH
- aplikace lokální MeSH
- granulom farmakoterapie MeSH
- imunosupresiva aplikace a dávkování MeSH
- lidé středního věku MeSH
- lidé MeSH
- obličejové dermatózy farmakoterapie MeSH
- takrolimus aplikace a dávkování MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
The authors present a rare case of double skin tumors: acral lentiginous melanoma and metatypical carcinoma. The tumors were manifested as gradually enlarging ulcerations on the leg and sole of the foot that did not respond to standard treatment. The skin biopsies showed advanced acral lentiginous melanoma on the sole and metatypical carcinoma of the lower leg. Soon after the diagnosis was made, the melanoma generalized. The article discusses the differential diagnosis of both leg ulcerations, correct diagnostic procedures, and characteristic features of both tumors that are important questions for general practitioners, dermatologists, and surgeons.
- MeSH
- diferenciální diagnóza MeSH
- karcinom diagnóza komplikace MeSH
- lidé MeSH
- melanom diagnóza komplikace MeSH
- mnohočetné primární nádory diagnóza komplikace MeSH
- nádory kůže diagnóza komplikace MeSH
- senioři MeSH
- vředy dolních končetin etiologie MeSH
- vředy na noze (od hlezna dolů) etiologie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- Publikační typ
- kazuistiky MeSH
- MeSH
- artróza kolenních kloubů patologie MeSH
- dospělí MeSH
- hojení ran MeSH
- lidé MeSH
- přežívání štěpu MeSH
- senioři MeSH
- transplantace kůže metody MeSH
- vředy dolních končetin terapie MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
- MeSH
- cévní endotel účinky léků MeSH
- dospělí MeSH
- endotelin-1 genetika MeSH
- fototerapie metody MeSH
- inhibitory ACE farmakologie terapeutické užití MeSH
- lidé MeSH
- lymfom T-buněčný patologie terapie MeSH
- polymorfismus genetický MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
