A wide array of antioxidative and anti-inflammatory substances derived from edible plants have been reported to possess chemopreventive and chemoprotective activities. Among the most extensively investigated and well-defined dietary chemopreventives is curcumin. Using the Ames test and in vivo micronucleus test, chemiluminescence test, blastic transformation test, and comet assay, we examined the antimutagenic effects of the chemically identified chemoprotective substance curcumin (diferuloylmethane) in the pure form on mutagenicity induced by three reference mutagens: aflatoxin B1 (AFB1), 2-amino-3-metylimidazo[4,5,-f] chinolin (IQ), and N-nitroso-N-metylurea (MNU), and the effect of curcumin on the immunosuppression caused by these mutagens. Curcumin in the pure form showed a clear antimutagenic and immunomodulatory activities on mutagenicity and immunosuppression induced by reference mutagens.

• MeSH
• aktivace lymfocytů genetika   MeSH
• antimutagenní látky analýza   MeSH
• imunologické techniky metody   MeSH
• kometový test MeSH
• kurkumin * analýza   metabolismus   MeSH
• luminiscenční měření MeSH
• myši MeSH
• Salmonella typhimurium MeSH
• testy karcinogenity * MeSH
• Check Tag
• myši MeSH
• Publikační typ
• práce podpořená grantem MeSH

• Konspekt
• Kuchařství. Potraviny. Vařená jídla