Flavocytochrome Dotaz Zobrazit nápovědu
- MeSH
- aceton farmakologie MeSH
- cytochrom B2 analýza MeSH
- dospělí MeSH
- izoenzymy MeSH
- kardiomyopatie enzymologie MeSH
- koronární nemoc enzymologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- nemoci srdce enzymologie MeSH
- nemoci srdečních chlopní enzymologie MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- MeSH
- alanintransaminasa krev MeSH
- alkalická fosfatasa krev MeSH
- aspartátaminotransferasy krev MeSH
- chuť MeSH
- cytochrom B2 krev MeSH
- hyperplazie endometria enzymologie patofyziologie MeSH
- lidé MeSH
- nádory dělohy enzymologie patofyziologie MeSH
- thiokarbamáty MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
Cellobiose dehydrogenase (CDH) from wood degrading fungi represents a subclass of oxidoreductases with unique properties. Consisting of two domains exhibiting interdomain electron transfer, this is the only known flavocytochrome involved in wood degradation. High resolution structures of the separated domains were solved, but the overall architecture of the intact protein and the exact interface of the two domains is unknown. Recently, it was shown that divalent cations modulate the activity of CDH and its pH optimum and a possible mechanism involving bridging of negative charges by calcium ions was proposed. Here we provide a structural explanation of this phenomenon confirming the interaction between negatively charged surface patches and calcium ions at the domain interface.