Nicholson TR*
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Světové duchovní proudy ; 47. sv.
Vyd. 1. 141 s. ; 20 cm
Ojedinělá antologie do níž přispělo deset světově proslulých léčitelů, psychologů, antropologů a odborníků na psychotroniku.
- Konspekt
- Okultismus
- NLK Obory
- okultní vědy
- NLK Publikační typ
- studie
... Obsah -- Autoři -- I Šamanské tradice -- Šamanismus Tamangů v Nepálu -- Larry G. ... ... Peters -- Šamanismus v židovské tradici -- Rabbi Yonassan Gershorn -- Cesta dobrodruha - tradice havajských ... ... Nandisvara Nayake Thero -- Transformační procesy v šamanismu, alchymii a józe -- Ralph Metzner -- Šamanismus ...
Světové duchovní proudy ; sv. 48
Vyd. 1. 125 s. ; 20 cm
Sborník prací na téma šamanismu. Druhý svazek antologie do níž, kromě psychologů a antropologů z nejvýznamnějších amerických universit, přispěl i rabín Yonassan Gershom.
- MeSH
- šamanismus MeSH
- Publikační typ
- populární práce MeSH
- Konspekt
- Okultismus
- NLK Obory
- okultní vědy
Je možné pomocí aktivního přístupu indukovaného porodu u rizikově těhotných zastavit nárůst počtu císařských řezů? Myšlenka je to jistě velmi kontroverzní a stojí v protikladu ke konvenčním expektativním postupům, ale může být správná!
Cytometric cellular analysis
1st ed. 442 s.
- Klíčová slova
- Program lidského mikrobiomu,
- MeSH
- gastrointestinální trakt mikrobiologie MeSH
- lidé MeSH
- metabolom * MeSH
- metabolomika * dějiny trendy MeSH
- mikrobiota * MeSH
- střevní mikroflóra * MeSH
- Check Tag
- lidé MeSH
- O autorovi
- Nicholson, Jeremy K Autorita
OBJECTIVES: Previous research shows only limited evidence on the contextual (neighbourhood-based) socioeconomic influences on mental health and depression. We investigated the association between individual and neighbourhood socioeconomic characteristics and depressive symptoms in the Czech Republic. METHODS: Dichotomized CESD score of depressive symptoms was used as the outcome in a random sample of 3534 men and 4082 women aged 45-69 years in the Czech HAPIEE Study. 220 small areas were characterized by the proportion of university educated persons and the proportion of unemployed from the economically active population in the 2001 Census. Multilevel logistic regression was used for the analysis. RESULTS: After controlling for individual-level variables, the effects of area-based characteristics were largely eliminated. The strongest area-based effect was that of the proportion of university educated persons; the ORs for 2(nd), 3(rd) and 4(th) quartile, compared with the 1(st) quartile, were 1.02, 0.93, and 0.82, respectively (p-value for trend 0.06). There were no cross-level interactions between socioeconomic variables. CONCLUSIONS: The effects of neighbourhood characteristics in this study were largely explained by individual socioeconomic variables.
- MeSH
- charakteristiky bydlení * MeSH
- chudoba * MeSH
- deprese ekonomika epidemiologie psychologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- logistické modely MeSH
- nezaměstnanost MeSH
- senioři MeSH
- stupeň vzdělání MeSH
- surveillance populace MeSH
- zdravotnické přehledy MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
- Geografické názvy
- Česká republika MeSH
Introduction We report the results of a phase I clinical trial NCT03790072 of an adoptive transfer of γδ T lymphocytes from haploidentical donors in patients with refractory/relapsed acute myeloid leukemia after lymphodepletion regimen. Patients and methods Healthy donor mononuclear cells collected by leukapheresis were consistently expanded to generate products of 109 to 1010 γδ T cells. Seven patients received donor-derived T cell product at doses of 106/kg (n = 3), 107/kg (n = 3), and 108/kg (n = 1). Results Four patients had bone marrow evaluation at day 28. One patient had a complete remission, one was classified as morphologic leukemia-free state, one had stable disease and one had no evidence of response. In one patient, there was evidence of disease control with repeat infusions up to 100 days after first dosing. There were no treatment-related serious adverse events or treatment-related Common Terminology Criteria for Adverse Events grade 3 or greater toxicities at any dose level. Allogeneic Vγ9Vδ2 T cell infusion was shown to be safe and feasible up to a cell dose of 108/kg. Discussion In agreement with previously published studies, the infusion of allogeneic Vγ9Vδ2 cells was safe. The contribution of lymphodepleting chemotherapy to responses seen cannot be ruled out. Main limitation of the study is the low number of patients and interruption due to COVID-19 pandemic. Conclusion These positive Phase 1 results support progression to phase II clinical trials.
- MeSH
- akutní myeloidní leukemie * terapie MeSH
- COVID-19 * MeSH
- lidé MeSH
- pandemie MeSH
- T-lymfocyty MeSH
- transplantace hematopoetických kmenových buněk * metody MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky, fáze I MeSH
- práce podpořená grantem MeSH
The development and selection of optimal outcome measures is increasingly recognized as a key component of evidence-based medicine, particularly the need for the development of a standardized set of measures for use in clinical trials. This process is particularly complex for functional neurological disorder (FND) for several reasons. FND can present with a wide range of symptoms that resemble the full spectrum of other neurological disorders. Additional physical (e.g., pain, fatigue) and psychological (e.g., depression, anxiety) symptoms are commonly associated with FND, which also can be highly disabling with implications for prognosis, and warrant concurrent assessment, despite an unclear etiological relationship with FND. Furthermore, several unique clinical aspects of FND make it likely that the usual prioritization of "objective" (or clinician-rated) over "subjective" (or patient-rated) measures might not be appropriate. Self-report measures may be more clinically meaningful in this patient population. Despite being a common and disabling disorder, there has been little research into outcome measures in FND, and to date trials have largely used measures designed for the assessment of other disorders. An international FND Core Outcome Measure group (FND-COM) has been established to develop a consensus battery of outcomes for FND: a "core outcome set." In this perspective article, the authors reviewed the process of outcome measure development and selection before considering the specific features of FND affecting the development of a core outcome set, as well as a research agenda to optimize outcome measurement in this complex neuropsychiatric disorder.
