cell-to-cell fusion
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... Cell fusion and membrane proteins 293 -- 5. Conclusions 297 -- 7 Virus-induced cell fusion, by G. ... ... Two kinds of virus-induced cell fusion 307 -- 3. ... ... Virus-cell interactions in virus-induced cell fusion 323 -- 6. Mechanisms 331 -- 6.1. ... ... Virus-to-cell and cell-to-cell fusion 331 -- 6.2. ... ... Protozoan membrane fusion 633 -- 4. Membrane fusion in mammalian secretory cells 633 -- 4.1. ...
Cell surface reviews ; volume 5
xxii, 862 stran : ilustrace ; 24 cm
- MeSH
- buněčná membrána MeSH
- fúze buněk MeSH
- fúze membrán MeSH
- fyziologie buňky MeSH
- membránové proteiny MeSH
- receptory buněčného povrchu MeSH
- Konspekt
- Buněčná biologie. Cytologie
- NLK Obory
- cytologie, klinická cytologie
- NLK Publikační typ
- kolektivní monografie
- MeSH
- buňky MeSH
- cytologické techniky MeSH
- fyziologie buňky MeSH
- hybridní buňky MeSH
- myši MeSH
- Check Tag
- myši MeSH
Methods in enzymology ; vol.220
1st ed. XXVI, 433 s. : obr., fot., grafy, přeruš.lit., věc.rejstř. ; 23 cm
- MeSH
- fúze buněk metody MeSH
- fúze membrán MeSH
- liposomy MeSH
- membránové lipidy fyziologie MeSH
- membrány umělé MeSH
- virová interference fyziologie MeSH
- Publikační typ
- sborníky MeSH
Prostatic basal cell carcinoma is a malignant neoplasm composed of basaloid cells forming infiltrative nests and tubules, which may potentially be misdiagnosed as benign basal cell proliferations (i.e., florid basal cell hyperplasia or basal cell adenoma) and also closely resembles adenoid cystic carcinoma of the salivary gland. MYB-NFIB gene rearrangement occurs in 30-86% of salivary gland adenoid cystic carcinomas. We sought to further characterize MYB gene rearrangement in prostatic basal cell carcinoma and correlate MYB-NFIB fusion status with other clinicopathologic characteristics. To this end, FISH analysis for MYB-NFIB gene fusion using fusion probes was performed on formalin-fixed, paraffin-embedded tissue sections from prostatic basal cell carcinoma (n = 30), florid basal cell hyperplasia (n = 18), and basal cell adenoma (n = 4). Fourteen of 30 (47%) cases of basal cell carcinoma were positive for MYB-NFIB gene fusion FISH, and no cases of benign basal cell proliferations were positive (p < 0.05). FISH-positive patients (mean age = 63 years, range: 35-81) tended to be younger than FISH-negative patients (mean age = 70 years, range: 55-93). Most FISH-positive cases demonstrated adenoid cystic carcinoma-like morphology (57%), and most FISH-negative cases demonstrated nonadenoid cystic carcinoma-like morphology (93%); one case (FISH-positive) demonstrated areas with both adenoid cystic carcinoma-like and nonadenoid cystic carcinoma-like morphology. FISH-positive cases more frequently demonstrated perineural invasion (50% vs. 14%, p < 0.05) compared to FISH-negative cases. Conversely, tall basal cells (i.e., neoplastic cells at least two times taller than wide) were more frequent in FISH-negative cases than FISH-positive cases (93% vs. 36%, p < 0.05). Approximately, 50% of prostatic basal cell carcinoma harbor MYB-NFIB gene fusion. The majority of these cases were characterized by adenoid cystic carcinoma-like morphology, perineural invasion, and lack tall basal cells. Florid basal cell hyperplasia and basal cell adenoma are negative for MYB-NFIB gene fusion.
- MeSH
- adenom genetika patologie MeSH
- bazocelulární karcinom genetika patologie MeSH
- dospělí MeSH
- fúzní onkogenní proteiny genetika MeSH
- hyperplazie genetika patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádory prostaty genetika patologie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
