OBJECTIVES: This study presents results of our randomized clinical trial studying the effect of human probiotics on memory and psychological and physical measures following our study protocol registered at clinicaltrials.gov NCT05051501 and described in detail in our previous paper. METHODS: Community dwelling participants aged between 55 and 80 years were randomly assigned to receive a single dose of 106 colony-forming units of human Streptococcus thermophilus GH, Streptococcus salivarius GH NEXARS, Lactobacilus plantarum GH, and Pediococcus pentosaceus GH or placebo. A cross-over design allowed each group to receive probiotics and placebo for 3 months each in reverse order. A small subset of participants was examined online due to the COVID-19 pandemic. After 6 months a small number of volunteers were additionally assessed after 2 months without any intervention. Primary outcome measures included changes in cognitive functions assessed using brief tests and a neuropsychological battery and changes in mood assessed using validated questionnaires. Secondary outcome measures included changes in self-report and subjective measures using depression and anxiety questionnaires, seven visual analog scales of subjective feelings (memory, digestion, etc.), and physical performance. RESULTS: At baseline, the probiotic-placebo group A (n = 40, age 69 ± 7 years, education 16 ± 3 years, 63% females, body mass index 28.5 ± 6, subjective memory complaint in 43%) did not differ from the placebo-probiotic group B (n = 32) in any of the sociodemographic characteristics and evaluated measures including cognitive status. At follow-up visits after 3, 6, and 8 months, no cross-sectional differences in any of the measures were found between the groups except worse sentence recall of the ALBA test after 3 months of probiotic use. Score changes were not observed for all cognitive tests but one in any group between visits 1 and 3 and between visits 3 and 6. The only change was observed for the TMT B test after the first three months but no change was observed after the second three months. CONCLUSION: The treatment with human probiotics and prebiotics did not improve cognitive, affective, or physical measures in community-dwelling individuals with normal or mildly impaired cognitive functions. CLINICAL TRIAL REGISTRATION: clinicaltrials.gov, identifier NCT05051501.
- Publication type
- Journal Article MeSH
BACKGROUND: Functional movement disorders (FMD) are associated with a high prevalence of psychiatric comorbidities. OBJECTIVE: To assess the frequency of obsessive-compulsive symptoms (OCS) in FMD. METHODS: A total of 167 consecutive patients with clinically definite FMD (mean age = 44.4 years, standard deviation [SD] = 12.0, 119 females) and 145 healthy controls (mean age = 43.2 years, SD = 11.8, 103 females) completed the Obsessive-Compulsive Inventory-Revised (OCI-R), which is a widely used tool for assessing OCS. The cutoff score ≥21 is indicative of clinically significant obsessive-compulsive disorder (OCD). Motor symptom severity was assessed using the Simplified FMD Rating Scale (S-FMDRS). All subjects completed questionnaires for depression, anxiety, pain, fatigue, cognitive complaints, health-related quality of life, and childhood trauma. Personality traits were assessed using the Big Five questionnaire. RESULTS: FMD patients had higher mean OCI-R score and higher proportion of individuals with OCI-R ≥ 21 42%, 95% confidence interval (CI) = (30.2, 54.6) versus 16%, 95% CI = (8.2, 28.2) in controls, P < 0.001. Patients had higher scores in three domains: checking, ordering, and obsessing (P < 0.001). FMD patients with OCI-R score ≥21 had higher depression, anxiety, cognitive complaints, and lower quality of life compared to those with score <21 (P < 0.001). No correlation between OCI-R and S-FMDRS scores was found. CONCLUSIONS: FMD patients reported higher rates of OCS compared to controls, along with higher rates of non-motor symptoms and lower quality of life. This finding may have clinical implications and raises the possibility of shared risk factors and common pathophysiological mechanisms in FMD and OCD.
- Publication type
- Journal Article MeSH
BACKGROUND: Patients with functional neurological disorders (FND) often present with multiple motor, sensory, psychological and cognitive symptoms. In order to explore the relationship between these common symptoms, we performed a detailed clinical assessment of motor, non-motor symptoms, health-related quality of life (HRQoL) and disability in a large cohort of patients with motor FND. To understand the clinical heterogeneity, cluster analysis was used to search for subgroups within the cohort. METHODS: One hundred fifty-two patients with a clinically established diagnosis of motor FND were assessed for motor symptom severity using the Simplified Functional Movement Disorder Rating Scale (S-FMDRS), the number of different motor phenotypes (i.e. tremor, dystonia, gait disorder, myoclonus, and weakness), gait severity and postural instability. All patients then evaluated each motor symptom type severity on a Likert scale and completed questionnaires for depression, anxiety, pain, fatigue, cognitive complaints and HRQoL. RESULTS: Significant correlations were found among the self-reported and all objective motor symptoms severity measures. All self-reported measures including HRQoL correlated strongly with each other. S-FMDRS weakly correlated with HRQoL. Hierarchical cluster analysis supplemented with gap statistics revealed a homogenous patient sample which could not be separated into subgroups. CONCLUSIONS: We interpret the lack of evidence of clusters along with a high degree of correlation between all self-reported and objective measures of motor or non-motor symptoms and HRQoL within current neurobiological models as evidence to support a unified pathophysiology of 'functional' symptoms. Our results support the unification of functional and somatic syndromes in classification schemes and for future mechanistic and therapeutic research.
- MeSH
- Conversion Disorder * MeSH
- Quality of Life * psychology MeSH
- Humans MeSH
- Syndrome MeSH
- Anxiety diagnosis MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
Cieľ: Výskumy poukazujú na potencionálny pozitívny vplyv nefarmakologických intervencií (NPI), ako je fyzioterapia a kognitívno-behaviorálna terapia (CBT) , na zdravotné výsledky u pacientov s chronickým ochorením. Aby sa uľahčila implementácia NPI založených na dôkazoch, prvým krokom je porozumieť širšiemu zdravotnému kontextu pacientov a ich preferencií ohľadom manažovania ochorenia. Cieľom tejto štúdie bolo preskúmať seba-reportované zdravotné problémy (SRHP) a záujem o NPI u pacientov s reumatoidnou artritídou (RA) podstupujúcich biologickú liečbu. Materiál a metódy: Výskumný súbor pozostával z 183 pacientov s RA (80,9 % žien; priemerný vek 55,6 ? 13,5 roka) z reumatologickej ambulancie v Košiciach na Slovensku. Otvorené otázky o SRHP a preferencie pre NPI, spolu so sociodemografickými (vek, pohlavie, vzdelanie, zamestnanie a bydlisko) a environmentálnymi charakteristikami (internetové pripojenie v domácnosti, vzdialenosť bydliska od nemocnice a doprovod do nemocnice) boli zozbierané prostredníctvom telefonického rozhovoru. Klinické charakteristiky pacientov (HAQ-DI, DAS28, dĺžka ochorenia a biologickej liečby) boli získané zo zdravotných záznamov. Výsledky: Fyzické zdravotné problémy uvádzalo 63,9 % pacientov a kombinované fyzické a mentálne problémy uvádzalo ďalších 33,3 %. Pacienti s viacerými SRHP (χ2 = 9,091, p < 0,01) a používatelia internetu (x2 = 14,380, p < 0,001) mali väčšiu pravdepodobnosť záujmu o NPI. Nenašli sme žiadne významné asociácie medzi preferenciou pre určitý typ NPI a sociodemografickými, klinickými, či environmentálnymi charakteristikami. Záver: Prevažná väčšina pacientov s RA bola otvorená NPI ako novému druhu doplnkovej liečby. Naše výsledky by mohli byť prínosom pre klinickú prax, nakoľko môžu napomôcť pri prispôsobovaní intervencií na základe najdôležitejších SRHP pacientov.
Objective: There is promising evidence for the positive impact of non-pharmacological interventions (NPIs) such as physiotherapy and cognitive behavioural therapy (CBT) in patients with a chronic disease. To facilitate the implementation of evidence-based NPIs, a first step is to understand patients ́ self-reported health problems (SRHPs) and their preferences for NPIs. This study aimed to explore patients ́ SRHPs and interests in NPIs in patients with rheumatoid arthritis (RA) undergoing biological treatment. Methods: We included 183 RA patients (80.9% females; mean age 55.6 ? 13.5 years) from the rheumatology outpatient department in Kosice, Slovakia. Open questions about SRHP and NPI preference, along with sociodemographic (age, gender, education, employment status, area where patient live) and environmental characteristics (home internet connection, distance from home to hospital, and companion on hospital visits) were collected through a telephone interview. Clinical characteristics of patients (HAQ-DI, DAS28, duration of disease and biologic therapy) were obtained from their medical records. Results: Physical health problems were reported by 63.9% of patients, and combined physical and mental health problems by an additional 33.3%. Patients with multiple SRHPs (χ2 = 9.091, p < 0.01) and Internet users (x2 = 14.380, p < 0.001) were more likely to be interested in NPIs. We found no significant associations between a preference for a certain type of NPI and sociodemographic, clinical, or environmental characteristics. Conclusions: The majority of RA patients were open to NPIs as a new kind of additional treatment. Our results could benefit practice by helping to tailor interventions based on the patients ́ most important SRHPs.
INTRODUCTION: Subjective cognitive deficits have been broadly reported in schizophrenia and described by Huber as basic symptoms. It remains unclear however to what extent they may be related to psychosocial stressors including trauma. METHODS: We assessed basic symptoms using the Frankfurt Complaint Questionnaire (FCQ) in a sample of 40 patients with schizophrenia. Trauma-related symptoms were assessed concurrently using the Trauma Symptom Checklist-40, symptoms of dissociation using the Dissociative Experiences Scale, and sensitization phenomena using the Complex Partial Seizure-like Symptoms Inventory and Limbic System Checklist-33. Psychotic symptoms were measured by Health of the Nation Outcome Scales. The dosage of antipsychotic medication was assessed in terms of equivalents of chlorpromazine, and antidepressant medication in terms of equivalents of fluoxetine. Spearman correlations were performed to explore the relationship between FCQ and other trauma-related measures. To determine the relative contributions of trauma-related symptoms to basic symptoms a linear regression analysis was performed. RESULTS: The results showed that higher levels of basic symptoms of schizophrenia were associated with greater levels of symptoms of dissociation, traumatic stress, and sensitization or kindling-like processes in schizophrenia. Among the trauma-related variables, sensitization phenomena assessed with Complex Partial Seizure-like Symptoms Inventory were closely associated with basic symptoms. DISCUSSION: These results indicate that basic symptoms measured by FCQ might be related to trauma. The potential of trauma to influence neurodevelopmental hypotheses of schizophrenia is discussed.
Topinková E, Jurašková B, Hrkal J, Zvolský M, Sládková P. Hodnocení disability s využitím nástroje WHODAS 2.0 u geriatrických pacientů. Pilotní studie WHODAS-GERI. Východiska. Disabilita ve stáří narůstá se zvyšujícím se věkem, polymorbiditou a geriatrickými syndromy, negativně ovlivňuje zdravotní stav a kvalitu života a má negativní sociální i ekonomické dopady. Proto je třeba vyhledávat v populaci seniory s disabilitou a kvantifikovat míru postižení. V ČR proběhla pilotní studie ověřující využitelnost mezinárodního dotazníkového nástroje WHODAS 2.0 u ambulantních geriatrických pacientů (WHODAS-GERI projekt) ve spolupráci ÚZIS ČR a České gerontologické a geriatrické společnosti ČLS JEP. Pacienti a metody. Prospektivní hodnocení 104 pacientů geriatrických ambulancí v 9 centrech, posouzení míry disability s využitím WHODAS 2.0 (36 otázek), posouzení soběstačnosti testy ADL, IADL, posouzení kognice testem MMSE a doplňující dotazníkové šetření u vyšetřujících geriatrů. Výsledky. Rozsah a závažnost celkové disability i 6 domén vycházejících z dotazníku WHODAS 2.0 dobře koreluje s celkovým skóre funkčních testů ADL, IADL a MMSE, rutinně používaných v rámci komplexního geriatrického hodnocení. V některých oblastech je doplňují i o údaje běžně nedostupné (vztahy s lidmi, participace na společenských aktivitách). To potvrdilo i hodnocení testujících lékařů, avšak z jejich hodnocení vyplývají také omezení použití tohoto dotazníku – náročnost vyplnění pro mnohé geriatrické pacienty, nízká specifičnost v některých oblastech a nemožnost jeho využití pro potřeby posudkové služby. Závěry. WHODAS 2.0 je validním nástrojem pro posouzení míry disability u ambulantních geriatrických pacientů. Jeho využití je vhodné za situací, kdy není prováděno komplexní geriatrické zhodnocení funkčního stavu, u vybraných specifických skupin geriatrických pacientů s chronickými stavy a pro zachycení širší oblasti kvality jejich života. Je vhodné provedení rozsáhlejších populačních studií u osob vyššího věku k získání normativních dat, údajů o prevalenci a charakteru disability a využití těchto znalostí pro tvorbu preventivních programů k omezení míry závislosti u seniorské populace.
Topinková E, Jurašková B, Hrkal J, Zvolský M, Sládková P. The assessment of disability using WHODAS 2.0 tool at geriatric patients. A pilot study WHODAS-GERI. Background. Disability in elderly people increases with advancing age, polymorbidity and presence of geriatric syndromes. It negatively influences health status, quality of life and has negative social and economic consequences. Therefore, seniors with disability should be identified and their disability quantified. In the Czech Republic a pilot study with international WHODAS 2.0 tool was conducted for the first time evaluating feasibility and usability of this tool in ambulatory geriatric out-patients in a WHODAS-GERI joint project of the Institute of Health Information and Statistics of the Czech Republic and Czech Society of Gerontology and Geriatrics, Czech Medical Association. Patients and methods. Prospective assessment of 104 patients of geriatric clinics in 9 centres, evaluation of disability level using WHODAS 2.0 questionnaire (36 items), self-sufficiency and independence using ADL and IADL tests and cognitive impairment using MMSE test; complementing questionnaire survey in geriatricians performing the assessment. Results. Extent and severity of the overall disability and of the 6 WHODAS 2.0 based domains correlate well with a total scores of functional tests ADL, IADL and MMSE, routinely used as part of comprehensive geriatric assessment. In some domains (interactions with other people, participation in social activities) WHODAS 2.0 provides information which are unknown/not routinely collected. This finding was supported by responses of participating physicians. However, their view on usability is rather cautious as for some patients completion of questionnaire was difficult, for low specificity of some domains and limits for direct use of the results for social allowances eligibility. Conclusions. WHODAS 2.0 seems to be a valid instrument for disability level in geriatric out-patients. Its use is supported when the comprehensive geriatric assessment and evaluation of the functional status and limitations cannot be performed, in selected groups of seniors with chronic conditions and if broader evaluation of quality of life is beneficial. In the future, larger epidemiologic population studies in seniors are needed to gain normative WHODAS 2.0 data, disability prevalence and for use of these information to design preventive programs to reduce dependency level of dependence in older people
- Keywords
- WHODAS 2.0,
- MeSH
- Activities of Daily Living MeSH
- Diagnostic Self Evaluation * MeSH
- Geriatrics MeSH
- Middle Aged MeSH
- Humans MeSH
- International Classification of Functioning, Disability and Health MeSH
- Prospective Studies MeSH
- Surveys and Questionnaires MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
BACKGROUND: Subjective cognitive complaints (SCCs) may represent an early cognitive marker of Alzheimer's disease (AD). There is a need to identify specific SCCs associated with an increased likelihood of underlying AD. OBJECTIVE: Using the Questionnaire of Cognitive Complaints (QPC), we evaluated the pattern of SCCs in a clinical sample of non-demented older adults in comparison to cognitively healthy community-dwelling volunteers (HV). METHODS: In total, 142 non-demented older adults from the Czech Brain Aging Study referred to two memory clinics for their SCCs were classified as having subjective cognitive decline (SCD, n = 85) or amnestic mild cognitive impairment (aMCI, n = 57) based on a neuropsychological evaluation. Furthermore, 82 age-, education-, and gender-matched HV were recruited. All subjects completed the QPC assessing the presence of specific SCCs in the last six months. RESULTS: Both SCD and aMCI groups reported almost two times more SCCs than HV, but they did not differ from each other in the total QPC score. Impression of memory change and Impression of worse memory in comparison to peers were significantly more prevalent in both SCD and aMCI groups in comparison to HV; however, only the latter one was associated with lower cognitive performance. CONCLUSION: The pattern of QPC-SCCs reported by SCD individuals was more similar to aMCI individuals than to HV. A complaint about memory change seems unspecific to pathological aging whereas a complaint about worse memory in comparison to peers might be one of the promising items from QPC questionnaire potentially reflecting subtle cognitive changes.
- MeSH
- Cognition physiology MeSH
- Cognitive Dysfunction psychology MeSH
- Middle Aged MeSH
- Humans MeSH
- Neuropsychological Tests MeSH
- Memory physiology MeSH
- Memory Disorders psychology MeSH
- Surveys and Questionnaires MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Aging psychology MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
BACKGROUND: Subjective cognitive complaints (SCCs) may represent an early cognitive marker of Alzheimer's disease (AD). There is a need to identify specific SCCs associated with an increased likelihood of underlying AD. OBJECTIVE: Using the Questionnaire of Cognitive Complaints (QPC), we evaluated the pattern of SCCs in a clinical sample of non-demented older adults in comparison to cognitively healthy community-dwelling volunteers (HV). METHODS: In total, 142 non-demented older adults from the Czech Brain Aging Study referred to two memory clinics for their SCCs were classified as having subjective cognitive decline (SCD, n = 85) or amnestic mild cognitive impairment (aMCI, n = 57) based on a neuropsychological evaluation. Furthermore, 82 age-, education-, and gender-matched HV were recruited. All subjects completed the QPC assessing the presence of specific SCCs in the last six months. RESULTS: Both SCD and aMCI groups reported almost two times more SCCs than HV, but they did not differ from each other in the total QPC score. Impression of memory change and Impression of worse memory in comparison to peers were significantly more prevalent in both SCD and aMCI groups in comparison to HV; however, only the latter one was associated with lower cognitive performance. CONCLUSION: The pattern of QPC-SCCs reported by SCD individuals was more similar to aMCI individuals than to HV. A complaint about memory change seems unspecific to pathological aging whereas a complaint about worse memory in comparison to peers might be one of the promising items from QPC questionnaire potentially reflecting subtle cognitive changes.
- MeSH
- Cognition physiology MeSH
- Cognitive Dysfunction psychology MeSH
- Middle Aged MeSH
- Humans MeSH
- Neuropsychological Tests MeSH
- Memory physiology MeSH
- Memory Disorders psychology MeSH
- Surveys and Questionnaires MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Aging psychology MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Cieľ: Viacfaktorový dotazník pamäti slúži na subjektívne posúdenie pamäti z perspektívy prežívania, výskytu kognitívnych omylov a využitia pamäťových stratégií. Cieľom výskumu je poskytnúť normatívne údaje k tomuto dotazníku u ľudí vo vyššom veku (viac ako 65 rokov). Materiál a metóda: Výskumný súbor tvorilo 157 participantov, ktorým bol administrovaný Viacfaktorový dotazník pamäti. Zber dát bol realizovaný v rámci projektu NEUROPSY v rokoch 2017-2018 vo všetkých regiónoch Slovenskej republiky. V aktuálnom príspevku sú analyzované v súvislosti s Viacfaktorovým dotazníkom pamäti metódy Montrealský kognitívny test, Poviedka a Opakovanie čísel. Výsledky: Analýza vzťahov k demografickým premenným, ako vek, pohlavie a počet rokov vzdelania, nezistila silné vzťahy. Celkové skóre v subškále Stratégie slabo korelovalo s celkovým skóre v teste MoCA. Ostatné vzťahy k objektívnym mieram kognície neboli štatisticky významné. Všetky subškály vykazovali vysokú mieru vnútornej konzistencie. Súčasťou výsledkov sú normatívne údaje pre celý súbor. Záver: Výsledky preukázali, že slovenská verzia Viacfaktorového dotazníka pamäti vykazuje vysokú mieru vnútornej konzistencie vo všetkých subškálach a nevykazuje silné vzťahy k demografickým premenným ani objektívnym mieram pamäti. Normatívne údaje umožnia v praxi presne kvantifikovať subjektívnych sťažností na pamäť.
Objective: Multifactorial Memory Questionnaire enables subjective assessment of memory from the perspective of satisfaction with memory functioning, self-appraisal of memory abilities, and self-reported use of memory strategies. The aim of the current study is to provide normative data to the questionnaire for people in older age (more than 65 years). Method: The sample consisted of 157 participants, who completed the Multifactorial Memory Questionnaire. The data collection was carried out within the project NEUROPSY in 2017?2018 in all regions of Slovakia. In current paper relationship between Multifactorial Memory Questionnaire and objective measures of cognition Montreal Cognitive Assessment, Story recall, and Digit Span are being analysed. Results: Analysis of the relations to demographic variables as age, sex and years of education did not reveal strong relationship. Overall score in subscale Strategy weakly correlated with overall score in MoCA. Other relations to objective measures of cognition were not statistically significant. All the subscales appear to have high internal consistency. A part of results are normative data for overall sample. Conclusion: The results revealed that Slovak version of Multifactorial memory questionnaire has high level of internal consistency in all subscales and is not strongly related to any demographic variables, nor objective memory assessment. Normative data enable to quantify subjective memory complaints in praxis.
- MeSH
- Data Interpretation, Statistical MeSH
- Cognitive Aging psychology MeSH
- Humans MeSH
- Neurobehavioral Manifestations MeSH
- Neuropsychology MeSH
- Memory Disorders psychology MeSH
- Psychometrics methods statistics & numerical data MeSH
- Aged * psychology statistics & numerical data MeSH
- Memory and Learning Tests * statistics & numerical data MeSH
- Self Report statistics & numerical data MeSH
- Check Tag
- Humans MeSH
- Aged * psychology statistics & numerical data MeSH
- Publication type
- Evaluation Study MeSH
- Research Support, Non-U.S. Gov't MeSH
Cíl: Pro pacienty s cévní mozkovou příhodou by mohlo být přínosem využití vertikálně prezentovaných sebehodnoticích škál bolesti. Tyto škály nejsou v českém jazyce k dispozici. Cílem bylo do českého jazyka přeložit Revidovanou verzi Iowské stupnice bolesti a provést její lingvistickou validaci tak, aby mohla být využita českými pacienty s cévní mozkovou příhodou. Metoda: Do této metodologické studie, probíhající od ledna do dubna 2017, byli zapojeni tři překladatelé, tři panely odborníků z oboru ošetřovatelství a sedm pacientů s cévní mozkovou příhodou. Celý proces byl řízen v souladu s guidelines International Society for Pharmacoeconomics and Outcomes Research. Tento proces, skládající se z 10 fází, byl podpořen kvantitativními a kvalitativními metodami, jako jsou index obsahové validity a výpočty modifikovaného koeficientu kappa, diskuse s odborníky z oboru ošetřovatelství i kognitivní rozhovor s pacienty. Výsledky: Předběžná česká verze byla vytvořena na základě indexu obsahové validity, hodnot modifikovaného koeficientu kappa a zpětné vazby od odborníků. Kognitivní rozhovor ukázal, že většina pacientů měla s použitím nástroje potíže. Závěr: Proces překladu a lingvistické validace byl náročný, protože bylo obtížné provést nábor sester a překladatelů splňujících stanovená výběrová kritéria; navíc se proces skládal z mnoha kroků. Avšak využití méně striktní metodologie by pravděpodobně vedlo k tvorbě české verze, která by pro zamýšlenou cílovou skupinu – české pacienty s cévní mozkovou příhodou – nebyla tak vhodná. Naše zjištění zdůrazňují, že je důležité do procesu překladu a lingvistické validace sebehodnoticích nástrojů zapojit reprezentativní uživatele, to znamená pacienty s konkrétním onemocněním. Psychometrické vlastnosti české verze budou zjišťovány ve výzkumném šetření, které bude zaměřené na české pacienty s cévní mozkovou příhodou.
Aim: Patients with a stroke could benefit from vertical self-report pain instruments. Such instruments are not available in the Czech language. The aim was to translate and linguistically validate the Revised Iowa Pain Thermometer into Czech for use by Czech patients with a stroke. Methods: Three translators, three nursing expert panels, and seven patients with a stroke participated in this methodological study that took place between January and April 2017. The International Society for Pharmacoeconomics and Outcomes Research guidelines were used to direct the process. This 10-phase process was supported by quantitative and qualitative methods, such as content validity indexing and modified kappa calculations, discussions with nursing experts, as well as cognitive debriefing with patients. Results: Based on the content validity index, the modified kappa values, and the experts’ feedback, a preliminary Czech version was developed. Cognitive debriefing revealed that most patients had some difficulty using the instrument. Conclusions: The translation and linguistic validation process was demanding as it was difficult to recruit nurses and translators meeting the determined selection criteria; furthermore, many steps were required. However, using a less stringent methodology would have probably produced a Czech version that would not be as suitable for the intended target group – Czech patients with a stroke. The findings underscore the importance of involving representative users, i.e., patients with a specific health condition, in the translation and linguistic validation of self-report instruments. Psychometric properties of the Czech version will be established in a clinical study that will involve Czech patients with strokes.
