OBJECTIVE. Lipoprotein-associated phospholipase A₂ (Lp-PLA₂) is extensively expressed by advanced atherosclerotic lesions and may play a role in plaque instability. We selected a group of elderly subjects that underwent transcatheter aortic valve implantation (TAVI) or balloon angioplasty (BA) and separated them into two groups, diabetic and nondiabetic, to compare the level of Lp-PLA₂ mass between them. METHODS. 44 patients aged 79.6 ± 5.6 years with symptomatic severe aortic valve stenosis underwent TAVI (n = 35) or BA (n = 9). 21 subjects had confirmed type 2 diabetes mellitus. Lp-PLA₂ mass was measured using an enzyme-linked immunosorbent assay kit (USCN Life Science, China) before and 3 days after the procedure. RESULTS. Lp-PLA₂ mass was significantly elevated in this population (1296 ± 358 ng/mL before TAVI; 1413 ± 268 ng/mL before BA) and further increased after TAVI (1604 ± 437 ng/mL, P < 0.01) or BA (1808 ± 303 ng/mL, P < 0.01). Lp-PLA₂ mass was significantly increased on the diabetic group before these interventions. CONCLUSION. Lp-PLA₂ may be a novel biomarker for the presence of rupture-prone atherosclerotic lesions in elderly patients. Levels of Lp-PLA₂ in diabetic patients may accompany the higher amount of small dense LDL particles seen in these subjects.
- MeSH
- 1-alkyl-2-acetylglycerofosfocholinesterasa krev MeSH
- aortální chlopeň chirurgie MeSH
- aortální stenóza komplikace chirurgie terapie MeSH
- aterosklerotický plát etiologie MeSH
- ateroskleróza krev komplikace enzymologie patofyziologie MeSH
- balónková angioplastika škodlivé účinky MeSH
- biologické markery krev MeSH
- chirurgická náhrada chlopně škodlivé účinky MeSH
- diabetes mellitus 2. typu komplikace MeSH
- diabetické angiopatie krev enzymologie patofyziologie MeSH
- lidé MeSH
- následné studie MeSH
- průřezové studie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- stárnutí * MeSH
- stupeň závažnosti nemoci MeSH
- upregulace * MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
