Smoldering multiple myeloma (SMM) is an asymptomatic precursor to active multiple myeloma (MM). The aim of this study was to report clinical characteristics and outcomes of patients with SMM stratified based on their risk of progression to MM using the Mayo 20/2/20 criteria. Data were leveraged from the Czech Myeloma Group Registry of Monoclonal Gammopathies (RMG). Key outcomes included progression-free survival from SMM diagnosis to active MM diagnosis or death (PFS), progression-free survival from SMM diagnosis to progression on first line (1 L) MM treatment or death (PFS2), and overall survival (OS). Of 498 patients, 174 (34.9%) were classified as high risk and 324 (65.1%) as non-high risk. Median follow-up was approximately 65 months. During follow-up, more patients in the high-risk vs non-high-risk group received 1 L MM treatment (76.4% vs 46.6%, p < 0.001). PFS, PFS2, and OS were significantly shorter in high-risk vs non-high-risk patients (13.2 vs 56.6 months, p < 0.001; 49.9 vs 84.9 months, p < 0.001; 93.2 vs 131.1 months, p = 0.012, respectively). The results of this study add to the growing body of evidence that patients with high-risk vs non-high-risk SMM have significantly worse outcomes, including OS.
- MeSH
- doba přežití bez progrese choroby MeSH
- doutnající mnohočetný myelom * diagnóza epidemiologie terapie MeSH
- lidé MeSH
- mnohočetný myelom * diagnóza epidemiologie terapie MeSH
- registrace MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika MeSH
- MeSH
- autoimunitní hemolytická anemie * diagnóza farmakoterapie imunologie MeSH
- hemolýza MeSH
- hormony kůry nadledvin aplikace a dávkování terapeutické užití MeSH
- idiopatická trombocytopenická purpura * diagnóza farmakoterapie imunologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- vakcíny proti COVID-19 škodlivé účinky MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
- MeSH
- lidé MeSH
- preanalytická fáze * MeSH
- vyšetření krevní srážlivosti * metody MeSH
- Check Tag
- lidé MeSH
- MeSH
- hemokoagulace * fyziologie MeSH
- lidé MeSH
- vyšetření krevní srážlivosti * metody MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
