11702399 OR Enzyme activities of Borrelia burgdorferi sensu lato Dotaz Zobrazit nápovědu
Lyme disease caused by spirochete Borrelia burgdorferi sensu lato, is a tick-born illness. If the infection is not eliminated by the host immune system and/or antibiotics, it may further disseminate and cause severe chronic complications. The immune response to Borrelia is mediated by phagocytic cells and by Borrelia-specific complement-activating antibodies associated with Th1 cell activation. A new experimental vaccine was constructed using non-lipidized form of recombinant B. burgdorferi s.s. OspC protein was anchored by metallochelating bond onto the surface of nanoliposomes containing novel nonpyrogenic lipophilized norAbuMDP analogues denoted MT05 and MT06. After i.d. immunization, the experimental vaccines surpassed Alum with respect to OspC-specific titers of IgG2a, IgG2b isotypes when MT06 was used and IgG3, IgM isotypes when MT05 was used. Both adjuvants exerted a high adjuvant effect comparable or better than MDP and proved themselves as nonpyrogenic.
- MeSH
- acetylmuramyl-alanyl-isoglutamin chemie toxicita MeSH
- antigeny bakteriální imunologie MeSH
- Borrelia burgdorferi imunologie MeSH
- chelátory chemie toxicita MeSH
- diferenciální skenovací kalorimetrie MeSH
- elektroforéza v polyakrylamidovém gelu MeSH
- ELISA MeSH
- liposomy MeSH
- myši inbrední BALB C MeSH
- myši MeSH
- nanočástice chemie toxicita MeSH
- nosiče léků chemie toxicita MeSH
- proteiny vnější bakteriální membrány imunologie MeSH
- protilátky bakteriální krev MeSH
- radiační rozptyl MeSH
- spektrometrie hmotnostní - ionizace laserem za účasti matrice MeSH
- světlo MeSH
- transmisní elektronová mikroskopie MeSH
- vakcína proti lymeské nemoci aplikace a dávkování imunologie MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
