The complement system is a major part of the innate immunity. The first component of the classical pathway of complement activation, C1q, plays a crucial role in the clearance of immune complexes and apoptotic bodies from the organism. Autoantibodies against C1q (anti-C1q) have been found in a number of autoimmune and infectious diseases. They have been best described in patients with systemic lupus erythematosus, where they are thought to play a pathogenic role in lupus nephritis (LN). Their high negative predictive value for the occurrence of active proliferative LN, as well as their possible ability to indicate a renal flare as soon as 6 months in advance, have rendered anti-C1q antibodies a novel non-invasive tool in the detection of active LN.

• MeSH
• apoptóza imunologie   MeSH
• autoprotilátky krev   MeSH
• biologické markery krev   MeSH
• financování organizované MeSH
• imunokomplex imunologie   MeSH
• klasická dráha komplementu MeSH
• komplement C1q imunologie   MeSH
• lidé MeSH
• nefritida při lupus erythematodes diagnóza   imunologie   MeSH
• přirozená imunita MeSH
• progrese nemoci MeSH
• systémový lupus erythematodes imunologie   krev   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH