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Complement component c1q and anti-c1q antibodies in theory and in clinical practice
E Potlukova, P Kralikova
Language English Country Great Britain
Grant support
NR8352
MZ0
CEP Register
Digital library NLK
Full text - Article
Source
NLK
Free Medical Journals
from 1997 to 1 year ago
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from 1997-01-01 to 2012-12-31
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from 1997 to 1 year ago
- MeSH
- Apoptosis immunology MeSH
- Autoantibodies blood MeSH
- Biomarkers blood MeSH
- Financing, Organized MeSH
- Antigen-Antibody Complex immunology MeSH
- Complement Pathway, Classical MeSH
- Complement C1q immunology MeSH
- Humans MeSH
- Lupus Nephritis diagnosis immunology MeSH
- Immunity, Innate MeSH
- Disease Progression MeSH
- Lupus Erythematosus, Systemic immunology blood MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
The complement system is a major part of the innate immunity. The first component of the classical pathway of complement activation, C1q, plays a crucial role in the clearance of immune complexes and apoptotic bodies from the organism. Autoantibodies against C1q (anti-C1q) have been found in a number of autoimmune and infectious diseases. They have been best described in patients with systemic lupus erythematosus, where they are thought to play a pathogenic role in lupus nephritis (LN). Their high negative predictive value for the occurrence of active proliferative LN, as well as their possible ability to indicate a renal flare as soon as 6 months in advance, have rendered anti-C1q antibodies a novel non-invasive tool in the detection of active LN.
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- $a The complement system is a major part of the innate immunity. The first component of the classical pathway of complement activation, C1q, plays a crucial role in the clearance of immune complexes and apoptotic bodies from the organism. Autoantibodies against C1q (anti-C1q) have been found in a number of autoimmune and infectious diseases. They have been best described in patients with systemic lupus erythematosus, where they are thought to play a pathogenic role in lupus nephritis (LN). Their high negative predictive value for the occurrence of active proliferative LN, as well as their possible ability to indicate a renal flare as soon as 6 months in advance, have rendered anti-C1q antibodies a novel non-invasive tool in the detection of active LN.
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