Biomolecular channels play important roles in many biological systems, e.g. enzymes, ribosomes and ion channels. This article introduces a web-based interactive MOLEonline 2.0 application for the analysis of access/egress paths to interior molecular voids. MOLEonline 2.0 enables platform-independent, easy-to-use and interactive analyses of (bio)macromolecular channels, tunnels and pores. Results are presented in a clear manner, making their interpretation easy. For each channel, MOLEonline displays a 3D graphical representation of the channel, its profile accompanied by a list of lining residues and also its basic physicochemical properties. The users can tune advanced parameters when performing a channel search to direct the search according to their needs. The MOLEonline 2.0 application is freely available via the Internet at http://ncbr.muni.cz/mole or http://mole.upol.cz.

• MeSH
• cytochrom P-450 CYP3A chemie   MeSH
• enzymy chemie   MeSH
• internet MeSH
• iontové kanály chemie   MeSH
• konformace proteinů MeSH
• molekulární modely MeSH
• počítačová grafika MeSH
• ribozomy chemie   MeSH
• software MeSH
• uživatelské rozhraní počítače MeSH
• velké podjednotky ribozomu archebakteriální chemie   MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH