23542236 OR The association of taxane resistance genes with the clinical course of ovarian carcinoma Dotaz Zobrazit nápovědu
Taxane and platinum-based chemotherapy regimens are standard treatment for advanced ovarian carcinoma. Expression levels of putative markers of taxane resistance in carcinoma tissues and paired peritoneal samples (n=55) and in 16 samples of ovaries without signs of carcinoma were compared with clinical data and the patients' time to progression. KIF14, PRC1, CIT and ABCC1 genes were significantly overexpressed in carcinomas when compared with normal ovarian tissues, while ABCB1 and CASP9 expression was decreased. Associations of protein expression of the proliferation marker Ki-67 with KIF14, PRC1, ABCB1 and CASP2 were found. Lastly, it was discovered that ABCB1 and CASP2 levels associated with FIGO stage and that the CIT level associated with the time to progression of ovarian carcinoma patients (P<0.0001). In conclusion, ABCB1, CASP2, KIF14, PRC1 and CIT genes seem to associate with surrogate markers of ovarian carcinoma progression and CIT gene associates with therapy outcome.
- MeSH
- ABC transportéry genetika MeSH
- adenokarcinom diagnóza farmakoterapie genetika MeSH
- antitumorózní látky terapeutické užití MeSH
- chemorezistence genetika MeSH
- genetické asociační studie MeSH
- intracelulární signální peptidy a proteiny genetika MeSH
- kaspasy genetika MeSH
- kineziny genetika MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádory vaječníků diagnóza farmakoterapie genetika MeSH
- onkogenní proteiny genetika MeSH
- ovarium metabolismus MeSH
- peritoneum metabolismus MeSH
- přemostěné cyklické sloučeniny terapeutické užití MeSH
- progrese nemoci MeSH
- protein-serin-threoninkinasy genetika MeSH
- proteiny buněčného cyklu genetika MeSH
- taxoidy terapeutické užití MeSH
- výsledek terapie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
