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Autor
Adli, Mazda 1 Akiyama, Kazufumi 1 Akula, Nirmala 1 Alda, Martin 1 Amare, Azmeraw T 1 Ardau, Raffaella 1 Arias, Bárbara 1 Aubry, Jean-Michel 1 Backlund, Lena 1 Bauer, Michael 1 Baune, Bernhard T 1 Bellivier, Frank 1 Benabarre, Antonio 1 Bengesser, Susanne 1 Bhattacharjee, Abesh Kumar 1 Biernacka, Joanna M 1 Cervantes, Pablo 1 Chen, Guo-Bo 1 Chen, Hsi-Chung 1 Chillotti, Caterina 1
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Pracoviště
Assistance Publique Hôpitaux de Paris... 1 Biometric Psychiatric Genetics Resear... 1 Bipolar Center Wiener Neustadt Austria 1 Bipolar and Depressive Disorders Unit... 1 CIBER de Salud Mental ISCIII Madrid B... 1 Campus for Ageing and Vitality Newcas... 1 Center for Computational Biology and ... 1 Child and Adolescent Psychiatry Resea... 1 Department of Adult Psychiatry Poznan... 1 Department of Biological Psychiatry a... 1 Department of Biomedical Sciences Uni... 1 Department of Biomedicine Aarhus Univ... 1 Department of Clinical Neuroscience K... 1 Department of Clinical Neurosciences ... 1 Department of Evolutive Biology Ecolo... 1 Department of Genetic Epidemiology in... 1 Department of Genetics Microbiology a... 1 Department of Health Sciences Researc... 1 Department of Medical Epidemiology an... 1 Department of Medical Sciences and Pu... 1
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Autor
Adli, Mazda 1 Akiyama, Kazufumi 1 Akula, Nirmala 1 Alda, Martin 1 Amare, Azmeraw T 1 Ardau, Raffaella 1 Arias, Bárbara 1 Aubry, Jean-Michel 1 Backlund, Lena 1 Bauer, Michael 1 Baune, Bernhard T 1 Bellivier, Frank 1 Benabarre, Antonio 1 Bengesser, Susanne 1 Bhattacharjee, Abesh Kumar 1 Biernacka, Joanna M 1 Cervantes, Pablo 1 Chen, Guo-Bo 1 Chen, Hsi-Chung 1 Chillotti, Caterina 1
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Pracoviště
Assistance Publique Hôpitaux de Paris... 1 Biometric Psychiatric Genetics Resear... 1 Bipolar Center Wiener Neustadt Austria 1 Bipolar and Depressive Disorders Unit... 1 CIBER de Salud Mental ISCIII Madrid B... 1 Campus for Ageing and Vitality Newcas... 1 Center for Computational Biology and ... 1 Child and Adolescent Psychiatry Resea... 1 Department of Adult Psychiatry Poznan... 1 Department of Biological Psychiatry a... 1 Department of Biomedical Sciences Uni... 1 Department of Biomedicine Aarhus Univ... 1 Department of Clinical Neuroscience K... 1 Department of Clinical Neurosciences ... 1 Department of Evolutive Biology Ecolo... 1 Department of Genetic Epidemiology in... 1 Department of Genetics Microbiology a... 1 Department of Health Sciences Researc... 1 Department of Medical Epidemiology an... 1 Department of Medical Sciences and Pu... 1
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Free Medical Journals od 2011
Nature Open Access od 2011-04-01
PubMed Central od 2011
Europe PubMed Central od 2011
ProQuest Central od 2011-04-01
Open Access Digital Library od 2011-01-01
Health & Medicine (ProQuest) od 2011-04-01
ROAD: Directory of Open Access Scholarly Resources od 2011
PubMed
38395906
DOI
10.1038/s41398-024-02811-4
Knihovny.cz E-zdroje
Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2039 patients from the International Consortium on Lithium Genetics (ConLiGen) study. We identified functional enrichment in focal adhesion and PI3K-Akt pathways, but we did not find an association with the ECM pathway. Our results suggest that deficits in the neuronal growth cone and PI3K-Akt signaling, but not in ECM proteins, may influence response to lithium in BD.
- MeSH
- bipolární porucha * farmakoterapie genetika MeSH
- celogenomová asociační studie MeSH
- fokální adheze MeSH
- fosfatidylinositol-3-kinasy genetika MeSH
- lidé MeSH
- lithium * farmakologie terapeutické užití MeSH
- multiomika MeSH
- protoonkogenní proteiny c-akt genetika MeSH
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- lidé MeSH
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- časopisecké články MeSH
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