-
Autor
Akaibe, Benjamin Dudu 1 Bletsa, Magda 1 Boonen, Ine 1 Bryja, Josef 1 Drexler, Jan Felix 1 Fikatas, Antonios 1 Gouy de Bellocq, Joelle 1 Gryseels, Sophie 1 Laudisoit, Anne 1 Leirs, Herwig 1 Lemey, Philippe 1 Lequime, Sebastian 1 Li, Yiqiao 1 Makundi, Rhodes 1 Mbalitini, Sylvestre Gambalemoke 1 Meheretu, Yonas 1 Pybus, Oliver G 1 Těšíková, Jana 1 Van Houtte, Natalie 1 Van Ranst, Marc 1
-
Pracoviště
Charite Universitatsmedizin Berlin Be... 1 Department of Biology Evolutionary Ec... 1 Department of Biology and Institute o... 1 Department of Botany and Zoology Facu... 1 Department of Ecology and Animal Reso... 1 Department of Microbiology Immunology... 1 Department of Pathobiology and Popula... 1 Department of Zoology University of O... 1 EcoHealth Alliance New York NY USA 1 German Center for Infection Research ... 1 Institute of Vertebrate Biology of th... 1 OD Taxonomy and Phylogeny Royal Belgi... 1 Pest Management Center Sokoine Univer... 1
- Formát
- Publikační typ
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
- Vlastník
-
Autor
Akaibe, Benjamin Dudu 1 Bletsa, Magda 1 Boonen, Ine 1 Bryja, Josef 1 Drexler, Jan Felix 1 Fikatas, Antonios 1 Gouy de Bellocq, Joelle 1 Gryseels, Sophie 1 Laudisoit, Anne 1 Leirs, Herwig 1 Lemey, Philippe 1 Lequime, Sebastian 1 Li, Yiqiao 1 Makundi, Rhodes 1 Mbalitini, Sylvestre Gambalemoke 1 Meheretu, Yonas 1 Pybus, Oliver G 1 Těšíková, Jana 1 Van Houtte, Natalie 1 Van Ranst, Marc 1
-
Pracoviště
Charite Universitatsmedizin Berlin Be... 1 Department of Biology Evolutionary Ec... 1 Department of Biology and Institute o... 1 Department of Botany and Zoology Facu... 1 Department of Ecology and Animal Reso... 1 Department of Microbiology Immunology... 1 Department of Pathobiology and Popula... 1 Department of Zoology University of O... 1 EcoHealth Alliance New York NY USA 1 German Center for Infection Research ... 1 Institute of Vertebrate Biology of th... 1 OD Taxonomy and Phylogeny Royal Belgi... 1 Pest Management Center Sokoine Univer... 1
- Formát
- Publikační typ
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
- Vlastník
PubMed Central od 2015
Europe PubMed Central od 2015
Open Access Digital Library od 2015-01-01
Open Access Digital Library od 2015-01-01
Oxford Journals Open Access Collection od 2015-01-01
ROAD: Directory of Open Access Scholarly Resources od 2015
PubMed
34221451
DOI
10.1093/ve/veab036
Knihovny.cz E-zdroje
Hepatitis C virus (HCV; genus Hepacivirus) represents a major public health problem, infecting about three per cent of the human population. Because no animal reservoir carrying closely related hepaciviruses has been identified, the zoonotic origins of HCV still remain unresolved. Motivated by recent findings of divergent hepaciviruses in rodents and a plausible African origin of HCV genotypes, we have screened a large collection of small mammals samples from seven sub-Saharan African countries. Out of 4,303 samples screened, eighty were found positive for the presence of hepaciviruses in twenty-nine different host species. We, here, report fifty-six novel genomes that considerably increase the diversity of three divergent rodent hepacivirus lineages. Furthermore, we provide strong evidence for hepacivirus co-infections in rodents, which were exclusively found in four sampled species of brush-furred mice. We also detect evidence of recombination within specific host lineages. Our study expands the available hepacivirus genomic data and contributes insights into the relatively deep evolutionary history of these pathogens in rodents. Overall, our results emphasize the importance of rodents as a potential hepacivirus reservoir and as models for investigating HCV infection dynamics.
- Publikační typ
- časopisecké články MeSH
Upřesnit dle MeSH
Sdílet
Název dokumentu
Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.