Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Molecular detection and genomic characterization of diverse hepaciviruses in African rodents

M. Bletsa, B. Vrancken, S. Gryseels, I. Boonen, A. Fikatas, Y. Li, A. Laudisoit, S. Lequime, J. Bryja, R. Makundi, Y. Meheretu, BD. Akaibe, SG. Mbalitini, F. Van de Perre, N. Van Houtte, J. Těšíková, E. Wollants, M. Van Ranst, OG. Pybus, JF....

. 2021 ; 7 (1) : veab036. [pub] 20210412

Language English Country Great Britain

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc21024651

Grant support
Wellcome Trust - United Kingdom

Hepatitis C virus (HCV; genus Hepacivirus) represents a major public health problem, infecting about three per cent of the human population. Because no animal reservoir carrying closely related hepaciviruses has been identified, the zoonotic origins of HCV still remain unresolved. Motivated by recent findings of divergent hepaciviruses in rodents and a plausible African origin of HCV genotypes, we have screened a large collection of small mammals samples from seven sub-Saharan African countries. Out of 4,303 samples screened, eighty were found positive for the presence of hepaciviruses in twenty-nine different host species. We, here, report fifty-six novel genomes that considerably increase the diversity of three divergent rodent hepacivirus lineages. Furthermore, we provide strong evidence for hepacivirus co-infections in rodents, which were exclusively found in four sampled species of brush-furred mice. We also detect evidence of recombination within specific host lineages. Our study expands the available hepacivirus genomic data and contributes insights into the relatively deep evolutionary history of these pathogens in rodents. Overall, our results emphasize the importance of rodents as a potential hepacivirus reservoir and as models for investigating HCV infection dynamics.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21024651
003      
CZ-PrNML
005      
20211013133831.0
007      
ta
008      
211006s2021 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.1093/ve/veab036 $2 doi
035    __
$a (PubMed)34221451
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Bletsa, Magda $u Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium
245    10
$a Molecular detection and genomic characterization of diverse hepaciviruses in African rodents / $c M. Bletsa, B. Vrancken, S. Gryseels, I. Boonen, A. Fikatas, Y. Li, A. Laudisoit, S. Lequime, J. Bryja, R. Makundi, Y. Meheretu, BD. Akaibe, SG. Mbalitini, F. Van de Perre, N. Van Houtte, J. Těšíková, E. Wollants, M. Van Ranst, OG. Pybus, JF. Drexler, E. Verheyen, H. Leirs, J. Gouy de Bellocq, P. Lemey
520    9_
$a Hepatitis C virus (HCV; genus Hepacivirus) represents a major public health problem, infecting about three per cent of the human population. Because no animal reservoir carrying closely related hepaciviruses has been identified, the zoonotic origins of HCV still remain unresolved. Motivated by recent findings of divergent hepaciviruses in rodents and a plausible African origin of HCV genotypes, we have screened a large collection of small mammals samples from seven sub-Saharan African countries. Out of 4,303 samples screened, eighty were found positive for the presence of hepaciviruses in twenty-nine different host species. We, here, report fifty-six novel genomes that considerably increase the diversity of three divergent rodent hepacivirus lineages. Furthermore, we provide strong evidence for hepacivirus co-infections in rodents, which were exclusively found in four sampled species of brush-furred mice. We also detect evidence of recombination within specific host lineages. Our study expands the available hepacivirus genomic data and contributes insights into the relatively deep evolutionary history of these pathogens in rodents. Overall, our results emphasize the importance of rodents as a potential hepacivirus reservoir and as models for investigating HCV infection dynamics.
655    _2
$a časopisecké články $7 D016428
700    1_
$a Vrancken, Bram $u Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium
700    1_
$a Gryseels, Sophie $u Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium $u Department of Biology, Evolutionary Ecology Group, University of Antwerp, Antwerp, Belgium
700    1_
$a Boonen, Ine $u Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium
700    1_
$a Fikatas, Antonios $u Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium
700    1_
$a Li, Yiqiao $u Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium
700    1_
$a Laudisoit, Anne $u EcoHealth Alliance, New York, NY, USA
700    1_
$a Lequime, Sebastian $u Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium
700    1_
$a Bryja, Josef $u Institute of Vertebrate Biology of the Czech Academy of Sciences, Brno, Czech Republic
700    1_
$a Makundi, Rhodes $u Pest Management Center -Sokoine University of Agriculture, Morogoro, Tanzania
700    1_
$a Meheretu, Yonas $u Department of Biology and Institute of Mountain Research & Development, Mekelle University, Mekelle, Ethiopia
700    1_
$a Akaibe, Benjamin Dudu $u Department of Ecology and Animal Resource Management, Faculty of Science, Biodiversity Monitoring Center, University of Kisangani, Kisangani, Democratic Republic of the Congo
700    1_
$a Mbalitini, Sylvestre Gambalemoke $u Department of Ecology and Animal Resource Management, Faculty of Science, Biodiversity Monitoring Center, University of Kisangani, Kisangani, Democratic Republic of the Congo
700    1_
$a Van de Perre, Frederik $u Department of Biology, Evolutionary Ecology Group, University of Antwerp, Antwerp, Belgium
700    1_
$a Van Houtte, Natalie $u Department of Biology, Evolutionary Ecology Group, University of Antwerp, Antwerp, Belgium
700    1_
$a Těšíková, Jana $u Institute of Vertebrate Biology of the Czech Academy of Sciences, Brno, Czech Republic $u Department of Botany and Zoology, Faculty of Science, Masaryk University, Brno, Czech Republic
700    1_
$a Wollants, Elke $u Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium
700    1_
$a Van Ranst, Marc $u Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium
700    1_
$a Pybus, Oliver G $u Department of Zoology, University of Oxford, Oxford, UK $u Department of Pathobiology and Population Sciences, The Royal Veterinary College, London, UK
700    1_
$a Drexler, Jan Felix $u Charite-Universitatsmedizin Berlin, Berlin, Germany $u German Center for Infection Research (DZIF), Berlin, Germany
700    1_
$a Verheyen, Erik $u Department of Biology, Evolutionary Ecology Group, University of Antwerp, Antwerp, Belgium $u OD Taxonomy and Phylogeny-Royal Belgian Institute of Natural Sciences, Brussels, Belgium
700    1_
$a Leirs, Herwig $u Department of Biology, Evolutionary Ecology Group, University of Antwerp, Antwerp, Belgium
700    1_
$a Gouy de Bellocq, Joelle $u Institute of Vertebrate Biology of the Czech Academy of Sciences, Brno, Czech Republic
700    1_
$a Lemey, Philippe $u Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium
773    0_
$w MED00200687 $t Virus evolution $x 2057-1577 $g Roč. 7, č. 1 (2021), s. veab036
856    41
$u https://pubmed.ncbi.nlm.nih.gov/34221451 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20211006 $b ABA008
991    __
$a 20211013133829 $b ABA008
999    __
$a ind $b bmc $g 1708410 $s 1145148
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 7 $c 1 $d veab036 $e 20210412 $i 2057-1577 $m Virus evolution $n Virus Evol $x MED00200687
GRA    __
$p Wellcome Trust $2 United Kingdom
LZP    __
$a Pubmed-20211006

Find record

Citation metrics

Archiving options