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Autor
Bednarek, Jacek 2 Blamek, Sławomir 2 Cybulska, Magdalena 2 Drzewiecka, Anna 2 Jadczyk, Tomasz 2 Latusek, Tomasz 2 Miszczyk, Marcin 2 Sajdok, Mateusz 2 Wojakowski, Wojciech 2 Bekman, Adam 1 Chmielik, Ewa 1 Dolla, Łukasz 1 Dyla, Agnieszka 1 Gardas, Rafał 1 Gołba, Krzysztof 1 Gołba, Krzysztof Stanisław 1 Grza Dziel, Aleksandra 1 Jarosiński, Grzegorz 1 Kaminiów, Konrad 1 Kozub, Anna 1
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Pracoviště
Department of Cardiology and Structur... 2 Department of Electrocardiology John ... 2 Department of Electrocardiology Upper... 2 Department of Electrocardiology and H... 2 Department of Radiotherapy Maria Skło... 2 3rd Department of Radiotherapy and Ch... 1 3rd Radiotherapy and Chemotherapy Dep... 1 Anaesthesiology and Intensive Care Un... 1 Department of Cardiac Surgery Heart a... 1 Department of Cardiac Surgery and Tra... 1 Department of Histopathology Silesian... 1 Department of Medical Physics Maria S... 1 Interventional Cardiac Electrophysiol... 1 Interventional Cardiac Electrophysiol... 1 Radiotherapy Planning Department Mari... 1 Tumor Pathology Department Maria Skło... 1
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Autor
Bednarek, Jacek 2 Blamek, Sławomir 2 Cybulska, Magdalena 2 Drzewiecka, Anna 2 Jadczyk, Tomasz 2 Latusek, Tomasz 2 Miszczyk, Marcin 2 Sajdok, Mateusz 2 Wojakowski, Wojciech 2 Bekman, Adam 1 Chmielik, Ewa 1 Dolla, Łukasz 1 Dyla, Agnieszka 1 Gardas, Rafał 1 Gołba, Krzysztof 1 Gołba, Krzysztof Stanisław 1 Grza Dziel, Aleksandra 1 Jarosiński, Grzegorz 1 Kaminiów, Konrad 1 Kozub, Anna 1
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Pracoviště
Department of Cardiology and Structur... 2 Department of Electrocardiology John ... 2 Department of Electrocardiology Upper... 2 Department of Electrocardiology and H... 2 Department of Radiotherapy Maria Skło... 2 3rd Department of Radiotherapy and Ch... 1 3rd Radiotherapy and Chemotherapy Dep... 1 Anaesthesiology and Intensive Care Un... 1 Department of Cardiac Surgery Heart a... 1 Department of Cardiac Surgery and Tra... 1 Department of Histopathology Silesian... 1 Department of Medical Physics Maria S... 1 Interventional Cardiac Electrophysiol... 1 Interventional Cardiac Electrophysiol... 1 Radiotherapy Planning Department Mari... 1 Tumor Pathology Department Maria Skło... 1
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PubMed Central od 2014
Europe PubMed Central od 2014
Open Access Digital Library od 2014-01-01
Open Access Digital Library od 2014-01-01
ROAD: Directory of Open Access Scholarly Resources od 2014
PubMed
35872906
DOI
10.3389/fcvm.2022.919823
Knihovny.cz E-zdroje
Cardiac stereotactic body radiotherapy is an emerging treatment method for recurrent ventricular tachycardia refractory to invasive treatment methods. The single-fraction delivery of 25 Gy was assumed to produce fibrosis, similar to a post-radiofrequency ablation scar. However, the dynamics of clinical response and recent preclinical findings suggest a possible different mechanism. The data on histopathological presentation of post-radiotherapy hearts is scarce, and the authors provide significantly different conclusions. In this article, we present unique data on histopathological examination of a heart explanted from a patient who had a persistent anti-arrhythmic response that lasted almost a year, until a heart failure exacerbation caused a necessity of a heart transplant. Despite a complete treatment response, there was no homogenous transmural fibrosis in the irradiated region, and the overall presentation of the heart was similar to other transplanted hearts of patients with advanced heart failure. In conclusion, our findings support the theorem of functional changes as a source of the anti-arrhythmic mechanism of radiotherapy and show that durable treatment response can be achieved in absence of transmural fibrosis of the irradiated myocardium.
- Publikační typ
- časopisecké články MeSH
Medline Complete (EBSCOhost) od 2013-04-01
ROAD: Directory of Open Access Scholarly Resources od 2003
PubMed
35076080
DOI
10.33963/kp.a2022.0019
Knihovny.cz E-zdroje
- MeSH
- fibrilace komor MeSH
- komorová tachykardie * chirurgie MeSH
- lidé MeSH
- srdeční arytmie MeSH
- zobrazování trojrozměrné MeSH
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- lidé MeSH
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- časopisecké články MeSH
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