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Autor
Albrecht, Randy 1 Allette, Kimaada 1 Ayllon, Juan 1 Byun, Minji 1 Fenouil, Romain 1 García-Sastre, Adolfo 1 Greenbaum, Benjamin 1 Guccione, Ernesto 1 Haddad, Bahareh 1 Ho, Jessica Sook Yuin 1 Hultquist, Judd 1 Jimenez-Morales, David 1 Jin, Jian 1 Krogan, Nevan 1 Low, Diana 1 Ma, Yixuan 1 Marazzi, Ivan 1 Mena, Nacho 1 Moshkina, Natasha 1 Pinto, Dalila 1
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Pracoviště
Cancer Cell Biology Programme Centro ... 1 Department of Cellular and Molecular ... 1 Department of Genomics and Multiscale... 1 Department of Medicine Clinical Immun... 1 Department of Medicine Northwestern U... 1 Department of Microbiology Icahn Scho... 1 Department of Microbiology Icahn Scho... 1 Department of Obstetrics and Gynecolo... 1 Department of Psychiatry Department o... 1 Epinova Epigenetics Discovery Perform... 1 Icahn Institute for Genomics and Mult... 1 Influenza Division National Center fo... 1 Institute of Molecular and Cell Biolo... 1 Laboratory of Immune Cell Epigenetics... 1 Life Science Research Centre Faculty ... 1 Mount Sinai Center for Therapeutics D... 1 Tisch Cancer Institute Icahn School o... 1
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Autor
Albrecht, Randy 1 Allette, Kimaada 1 Ayllon, Juan 1 Byun, Minji 1 Fenouil, Romain 1 García-Sastre, Adolfo 1 Greenbaum, Benjamin 1 Guccione, Ernesto 1 Haddad, Bahareh 1 Ho, Jessica Sook Yuin 1 Hultquist, Judd 1 Jimenez-Morales, David 1 Jin, Jian 1 Krogan, Nevan 1 Low, Diana 1 Ma, Yixuan 1 Marazzi, Ivan 1 Mena, Nacho 1 Moshkina, Natasha 1 Pinto, Dalila 1
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Pracoviště
Cancer Cell Biology Programme Centro ... 1 Department of Cellular and Molecular ... 1 Department of Genomics and Multiscale... 1 Department of Medicine Clinical Immun... 1 Department of Medicine Northwestern U... 1 Department of Microbiology Icahn Scho... 1 Department of Microbiology Icahn Scho... 1 Department of Obstetrics and Gynecolo... 1 Department of Psychiatry Department o... 1 Epinova Epigenetics Discovery Perform... 1 Icahn Institute for Genomics and Mult... 1 Influenza Division National Center fo... 1 Institute of Molecular and Cell Biolo... 1 Laboratory of Immune Cell Epigenetics... 1 Life Science Research Centre Faculty ... 1 Mount Sinai Center for Therapeutics D... 1 Tisch Cancer Institute Icahn School o... 1
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NLK
ProQuest Central
od 2004-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2004-01-01 do Před 1 rokem
PubMed
30177761
DOI
10.1038/s41594-018-0124-7
Knihovny.cz E-zdroje
Viral infection perturbs host cells and can be used to uncover regulatory mechanisms controlling cellular responses and susceptibility to infections. Using cell biological, biochemical, and genetic tools, we reveal that influenza A virus (IAV) infection induces global transcriptional defects at the 3' ends of active host genes and RNA polymerase II (RNAPII) run-through into extragenic regions. Deregulated RNAPII leads to expression of aberrant RNAs (3' extensions and host-gene fusions) that ultimately cause global transcriptional downregulation of physiological transcripts, an effect influencing antiviral response and virulence. This phenomenon occurs with multiple strains of IAV, is dependent on influenza NS1 protein, and can be modulated by SUMOylation of an intrinsically disordered region (IDR) of NS1 expressed by the 1918 pandemic IAV strain. Our data identify a strategy used by IAV to suppress host gene expression and indicate that polymorphisms in IDRs of viral proteins can affect the outcome of an infection.
- MeSH
- chřipka lidská genetika MeSH
- lidé MeSH
- RNA-polymerasa II genetika MeSH
- terminátorové oblasti (genetika) genetika MeSH
- virulence MeSH
- virus chřipky A patogenita fyziologie MeSH
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- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
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