Histone deacetylase (HDAC) inhibitors have shown beneficial effects in animal models of cardiovascular diseases. We hypothesized that HDAC inhibitor, sodium valproate (VPA), has cardiac and vascular protective effects in rats with pressure overload cardiac hypertrophy induced by transverse aortic constriction (TAC). Sections of the heart were visualized after hematoxylin and eosin staining, picrosirius red staining and immunohistochemistry. The expression of genes related to cardiac hypertrophy, fibrosis, and oxidative stress was determined by quantitative real-time polymerase chain reaction. The aortic ring tension analysis was conducted using both the ascending aorta and descending thoracic aorta. TAC increased the expression of hypertrophic, fibrotic, and oxidative stress genes, which was attenuated by VPA. In the ascending aorta with intact endothelium, there was a significant decrease in the relaxation response, which was recovered by VPA treatment. These results indicate that VPA has cardiac and vascular protective effects in rats with pressure overload cardiac hypertrophy.

• MeSH
• aorta chirurgie   patofyziologie   účinky léků   MeSH
• arteriální tlak účinky léků   MeSH
• fibróza MeSH
• funkce levé komory srdeční účinky léků   MeSH
• hypertrofie levé komory srdeční metabolismus   patofyziologie   patologie   prevence a kontrola   MeSH
• inhibitory histondeacetylas farmakologie   MeSH
• kyselina valproová farmakologie   MeSH
• ligace MeSH
• modely nemocí na zvířatech MeSH
• myokard metabolismus   patologie   MeSH
• oxidační stres účinky léků   MeSH
• potkani Sprague-Dawley MeSH
• regulace genové exprese MeSH
• remodelace komor účinky léků   MeSH
• vazodilatace účinky léků   MeSH
• vazodilatancia farmakologie   MeSH
• zvířata MeSH
• Check Tag
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH