Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Histone deacetylase inhibition has cardiac and vascular protective effects in rats with pressure overload cardiac hypertrophy

H. Jung, E. Lee, I. Kim, J. H. Song, G. J. Kim

. 2019 ; 68 (5) : 727-737. [pub] 20190819

Jazyk angličtina Země Česko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc20005497

Histone deacetylase (HDAC) inhibitors have shown beneficial effects in animal models of cardiovascular diseases. We hypothesized that HDAC inhibitor, sodium valproate (VPA), has cardiac and vascular protective effects in rats with pressure overload cardiac hypertrophy induced by transverse aortic constriction (TAC). Sections of the heart were visualized after hematoxylin and eosin staining, picrosirius red staining and immunohistochemistry. The expression of genes related to cardiac hypertrophy, fibrosis, and oxidative stress was determined by quantitative real-time polymerase chain reaction. The aortic ring tension analysis was conducted using both the ascending aorta and descending thoracic aorta. TAC increased the expression of hypertrophic, fibrotic, and oxidative stress genes, which was attenuated by VPA. In the ascending aorta with intact endothelium, there was a significant decrease in the relaxation response, which was recovered by VPA treatment. These results indicate that VPA has cardiac and vascular protective effects in rats with pressure overload cardiac hypertrophy.

Citace poskytuje Crossref.org

Bibliografie atd.

Literatura

000      
00000naa a2200000 a 4500
001      
bmc20005497
003      
CZ-PrNML
005      
20200527142045.0
007      
ta
008      
200511s2019 xr ad f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.934110 $2 doi
035    __
$a (PubMed)31424255
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Jung, H. $u Department of Thoracic and Cardiovascular Surgery, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea
245    10
$a Histone deacetylase inhibition has cardiac and vascular protective effects in rats with pressure overload cardiac hypertrophy / $c H. Jung, E. Lee, I. Kim, J. H. Song, G. J. Kim
504    __
$a Literatura
520    9_
$a Histone deacetylase (HDAC) inhibitors have shown beneficial effects in animal models of cardiovascular diseases. We hypothesized that HDAC inhibitor, sodium valproate (VPA), has cardiac and vascular protective effects in rats with pressure overload cardiac hypertrophy induced by transverse aortic constriction (TAC). Sections of the heart were visualized after hematoxylin and eosin staining, picrosirius red staining and immunohistochemistry. The expression of genes related to cardiac hypertrophy, fibrosis, and oxidative stress was determined by quantitative real-time polymerase chain reaction. The aortic ring tension analysis was conducted using both the ascending aorta and descending thoracic aorta. TAC increased the expression of hypertrophic, fibrotic, and oxidative stress genes, which was attenuated by VPA. In the ascending aorta with intact endothelium, there was a significant decrease in the relaxation response, which was recovered by VPA treatment. These results indicate that VPA has cardiac and vascular protective effects in rats with pressure overload cardiac hypertrophy.
650    _2
$a zvířata $7 D000818
650    _2
$a aorta $x chirurgie $x patofyziologie $x účinky léků $7 D001011
650    _2
$a arteriální tlak $x účinky léků $7 D062186
650    _2
$a modely nemocí na zvířatech $7 D004195
650    _2
$a fibróza $7 D005355
650    _2
$a regulace genové exprese $7 D005786
650    _2
$a inhibitory histondeacetylas $x farmakologie $7 D056572
650    _2
$a hypertrofie levé komory srdeční $x metabolismus $x patofyziologie $x patologie $x prevence a kontrola $7 D017379
650    _2
$a ligace $7 D008026
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a myokard $x metabolismus $x patologie $7 D009206
650    _2
$a oxidační stres $x účinky léků $7 D018384
650    _2
$a potkani Sprague-Dawley $7 D017207
650    _2
$a kyselina valproová $x farmakologie $7 D014635
650    _2
$a vazodilatace $x účinky léků $7 D014664
650    _2
$a vazodilatancia $x farmakologie $7 D014665
650    _2
$a funkce levé komory srdeční $x účinky léků $7 D016277
650    _2
$a remodelace komor $x účinky léků $7 D020257
655    _2
$a časopisecké články $7 D016428
700    1_
$a Lee, E. $u Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea; BK21 PLUS KNU Biomedical Convergence Program, School of Medicine, Kyungpook National University, Daegu, Republic of Korea; Cardiovascular Research Institute, Kyungpook National University, Daegu, Republic of Korea; Cell and Matrix Research Institute, Kyungpook National University, Daegu, Republic of Korea
700    1_
$a Kim, I. $u Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea; BK21 PLUS KNU Biomedical Convergence Program, School of Medicine, Kyungpook National University, Daegu, Republic of Korea; Cardiovascular Research Institute, Kyungpook National University, Daegu, Republic of Korea; Cell and Matrix Research Institute, Kyungpook National University, Daegu, Republic of Korea
700    1_
$a Song, J. H. $u Division of Public Health Medical Service, Kyungpook National University Hospital, Daegu, Republic of Korea
700    1_
$a Kim, G. J. $u Department of Thoracic and Cardiovascular Surgery, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 68, č. 5 (2019), s. 727-737
856    41
$u https://pubmed.ncbi.nlm.nih.gov/31424255 $y Pubmed
910    __
$a ABA008 $b A 4120 $c 266 $y p $z 0
990    __
$a 20200511 $b ABA008
991    __
$a 20200526134603 $b ABA008
999    __
$a ok $b bmc $g 1528598 $s 1095552
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2019 $b 68 $c 5 $d 727-737 $e 20190819 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
LZP    __
$b NLK118 $a Pubmed-20200511

Najít záznam

Citační ukazatele

Možnosti archivace