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Autor
Abramenko, Nikita 1 Balvan, Jan 1 Brábek, Jan 1 Fialova, Jindriska Leischner 1 Gumulec, Jaromir 1 Hönigova, Katerina 1 Jakubek, Milan 1 Kaplanek, Robert 1 Kejik, Zdenek 1 Martasek, Pavel 1 Masarik, Michal 1 Miksatkova, Lucie 1 Moturu, Taraka Ramji 1 Navrátil, Jiří 1 Neuzil, Jiri 1 Raudenska, Martina 1 Rosel, Daniel 1 Vesela, Katerina 1 Vicar, Tomas 1 Zobalová, Renata 1
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Pracoviště
BIOCEV 1st Faculty of Medicine Charle... 1 Biotechnology and Biomedicine Centre ... 1 Crop Production and Biostimulation La... 1 Department of Cell Biology Charles Un... 1 Department of Chemistry and Biochemis... 1 Department of Paediatrics and Inherit... 1 Department of Pathological Physiology... 1 Department of Physiology Faculty of M... 1 Faculty of Science Charles University... 1 Institute of Biotechnology Czech Acad... 1 School of Pharmacy and Medical Scienc... 1
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Autor
Abramenko, Nikita 1 Balvan, Jan 1 Brábek, Jan 1 Fialova, Jindriska Leischner 1 Gumulec, Jaromir 1 Hönigova, Katerina 1 Jakubek, Milan 1 Kaplanek, Robert 1 Kejik, Zdenek 1 Martasek, Pavel 1 Masarik, Michal 1 Miksatkova, Lucie 1 Moturu, Taraka Ramji 1 Navrátil, Jiří 1 Neuzil, Jiri 1 Raudenska, Martina 1 Rosel, Daniel 1 Vesela, Katerina 1 Vicar, Tomas 1 Zobalová, Renata 1
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Pracoviště
BIOCEV 1st Faculty of Medicine Charle... 1 Biotechnology and Biomedicine Centre ... 1 Crop Production and Biostimulation La... 1 Department of Cell Biology Charles Un... 1 Department of Chemistry and Biochemis... 1 Department of Paediatrics and Inherit... 1 Department of Pathological Physiology... 1 Department of Physiology Faculty of M... 1 Faculty of Science Charles University... 1 Institute of Biotechnology Czech Acad... 1 School of Pharmacy and Medical Scienc... 1
- Formát
- Publikační typ
- Check Tag
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
- Vlastník
- Fialova, Jindriska Leischner
- Hönigova, Katerina
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Raudenska, Martina
Autor Raudenska, Martina Department of Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, CZ-625 00 Brno, Czech Republic Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, CZ-625 00 Brno, Czech Republic Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, CZ-613 00, Brno, Czech Republic
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Miksatkova, Lucie
Autor Miksatkova, Lucie BIOCEV, First Faculty of Medicine, Charles University, Prumyslova 595, CZ-252 50 Vestec, Czech Republic Department of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital in Prague, Ke Karlovu 455, 120 00 Prague, Czech Republic
- Zobalová, Renata
- Navrátil, Jiří
- Šmigová, Jana
- Moturu, Taraka Ramji
- Vicar, Tomas
- Balvan, Jan
NLK
Directory of Open Access Journals
od 2018
Elsevier Open Access Journals
od 2018-12-01
ROAD: Directory of Open Access Scholarly Resources
od 2002
PubMed
36055111
DOI
10.1016/j.biopha.2022.113582
Knihovny.cz E-zdroje
Mitochondria generate energy and building blocks required for cellular growth and function. The notion that mitochondria are not involved in the cancer growth has been challenged in recent years together with the emerging idea of mitochondria as a promising therapeutic target for oncologic diseases. Pentamethinium salts, cyan dyes with positively charged nitrogen on the benzothiazole or indole part of the molecule, were originally designed as mitochondrial probes. In this study, we show that pentamethinium salts have a strong effect on mitochondria, suppressing cancer cell proliferation and migration. This is likely linked to the strong inhibitory effect of the salts on dihydroorotate dehydrogenase (DHODH)-dependent respiration that has a key role in the de novo pyrimidine synthesis pathway. We also show that pentamethinium salts cause oxidative stress, redistribution of mitochondria, and a decrease in mitochondria mass. In conclusion, pentamethinium salts present novel anti-cancer agents worthy of further studies.
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