Geosmithia fungi are little known symbionts of bark beetles. Secondary metabolites of lilac colored species G. lavendula and other nine Geosmithia species were investigated in order to elucidate their possible role in the interactions of the fungi with environment. Hydroxylated anthraquinones (yellow, orange, and red pigments), were found to be the most abundant compounds produced into the medium during the submerged cultivation. Three main compounds were identified as 1,3,6,8-tetrahydroxyanthraquinone (1), rhodolamprometrin (1-acetyl-2,4,5,7-tetrahydroxyanthraquinone; 2), and 1-acetyl-2,4,5,7,8-pentahydroxyanthraquinone (3). Compounds 2 and 3 (representing the majority of produced metabolites) inhibited the growth of G+-bacteria Staphylococcus aureus and Bacillus subtilis with minimum inhibitory concentration of 64-512 microg/mL. Anti-inflammatory activity detected as inhibition of cyclooxygenase-2 was found only for compound 3 at 1 and 10 microg/mL. Compound 2 interfered with the morphology, compound 3 with cell-cycle dynamics of adherent mammalian cell lines.
- MeSH
- anthrachinony farmakologie chemie metabolismus MeSH
- antibakteriální látky farmakologie chemie metabolismus MeSH
- antiflogistika nesteroidní farmakologie chemie metabolismus MeSH
- Bacillus subtilis účinky léků MeSH
- biologické pigmenty farmakologie chemie metabolismus MeSH
- biotechnologie metody MeSH
- buněčný cyklus účinky léků MeSH
- Ficus parazitologie MeSH
- financování organizované MeSH
- HeLa buňky MeSH
- hydroxylace MeSH
- Hypocreales metabolismus růst a vývoj MeSH
- inhibitory cyklooxygenasy farmakologie chemie metabolismus MeSH
- lidé MeSH
- nosatcovití fyziologie mikrobiologie MeSH
- spory hub metabolismus růst a vývoj MeSH
- Staphylococcus aureus účinky léků MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- MeSH
- erytrocyty metabolismus MeSH
- hypertenze MeSH
- lidé MeSH
- sodík analýza MeSH
- Check Tag
- lidé MeSH
