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Autor: Brozman, Miroslav

250 záznamů v Články Filtry

Článek

Safety and Outcomes of Thrombectomy in Ischemic Stroke With vs Without IV Thrombolysis

Ahmed, Niaz
Autor Ahmed, Niaz From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy Department of Neurology (D.S.), Helsinki University Central Hospital, Finland IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic Department of Neurology University Hospital Ostrava (E.H.), Czech Republic Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden. niaz.ahmed@ki.se
Mazya, Michael
Autor Mazya, Michael From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy Department of Neurology (D.S.), Helsinki University Central Hospital, Finland IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic Department of Neurology University Hospital Ostrava (E.H.), Czech Republic Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden
Nunes, Ana Paiva
Autor Nunes, Ana Paiva From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy Department of Neurology (D.S.), Helsinki University Central Hospital, Finland IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic Department of Neurology University Hospital Ostrava (E.H.), Czech Republic Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden
Moreira, Tiago
Autor Moreira, Tiago From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy Department of Neurology (D.S.), Helsinki University Central Hospital, Finland IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic Department of Neurology University Hospital Ostrava (E.H.), Czech Republic Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden
Ollikainen, Jyrki P
Autor Ollikainen, Jyrki P From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy Department of Neurology (D.S.), Helsinki University Central Hospital, Finland IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic Department of Neurology University Hospital Ostrava (E.H.), Czech Republic Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden
Escudero-Martínez, Irene
Autor Escudero-Martínez, Irene From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy Department of Neurology (D.S.), Helsinki University Central Hospital, Finland IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic Department of Neurology University Hospital Ostrava (E.H.), Czech Republic Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden
Bigliardi, Guido
Autor Bigliardi, Guido From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy Department of Neurology (D.S.), Helsinki University Central Hospital, Finland IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic Department of Neurology University Hospital Ostrava (E.H.), Czech Republic Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden
Dorado, Laura
Autor Dorado, Laura From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy Department of Neurology (D.S.), Helsinki University Central Hospital, Finland IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic Department of Neurology University Hospital Ostrava (E.H.), Czech Republic Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden
Dávalos, Antoni
Autor Dávalos, Antoni From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy Department of Neurology (D.S.), Helsinki University Central Hospital, Finland IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic Department of Neurology University Hospital Ostrava (E.H.), Czech Republic Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden
Egido, Jose A
Autor Egido, Jose A From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy Department of Neurology (D.S.), Helsinki University Central Hospital, Finland IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic Department of Neurology University Hospital Ostrava (E.H.), Czech Republic Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden

Neurology. 2021 ; 97 (8) : e765-e776. [pub] 20210604

ISSN 1526-632X
Medvik
Zdroj

OBJECTIVE: To test the hypothesis that IV thrombolysis (IVT) treatment before endovascular thrombectomy (EVT) is associated with better outcomes in patients with anterior circulation large artery occlusion (LAO) stroke, we examined a large real-world database, the Safe Implementation of Treatment in Stroke-International Stroke Thrombectomy Register (SITS-ISTR). METHODS: We identified centers recording ≥10 consecutive patients in the SITS-ISTR, with at least 70% available modified Rankin Scale (mRS) scores at 3 months during 2014 to 2019. We defined LAO as intracranial internal carotid artery, first and second segment of middle cerebral artery, and first segment of anterior cerebral artery. Main outcomes were functional independence (mRS score 0-2) and death at 3 months and symptomatic intracranial hemorrhage (SICH) per modified SITS-Monitoring Study. We performed propensity score-matched (PSM) and multivariable logistic regression analyses. RESULTS: Of 6,350 patients from 42 centers, 3,944 (62.1%) received IVT. IVT + EVT-treated patients had less frequent atrial fibrillation, ongoing anticoagulation, previous stroke, heart failure, and prestroke disability. PSM analysis showed that IVT + EVT-treated patients had a higher rate of functional independence than patients treated with EVT alone (46.4% vs 40.3%, p < 0.001) and a lower rate of death at 3 months (20.3% vs 23.3%, p = 0.035). SICH rates (3.5% vs 3.0%, p = 0.42) were similar in both groups. Multivariate adjustment yielded results consistent with PSM. CONCLUSION: Pretreatment with IVT was associated with favorable outcomes in EVT-treated LAO stroke in the SITS-ISTR. These findings, while indicative of international routine clinical practice, are limited by observational design, unmeasured confounding, and possible residual confounding by indication. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that IVT before EVT increases the probability of functional independence at 3 months compared to EVT alone.

Abstrakt

Tichý mozgový infarkt pri koronárnej katetrizácii. Myslí intervenčný kardiológ aj na mozog?

Cardiology letters. 2019 ; 28 (Suppl.) : 29S.

ISSN 1338-3655
Medvik
Zdroj

Kongres Slovenskej kardiologickej spoločnosti. 2019 ; () : 29S.

Medvik
Zdroj

Publikační typ
abstrakt z konference MeSH

Článek

Safety and Outcome of Intravenous Thrombolysis in Stroke Patients on Prophylactic Doses of Low Molecular Weight Heparins at Stroke Onset

Stroke. 2019 ; 50 (5) : 1149-1155. [pub] -

ISSN 1524-4628
Medvik
Zdroj

Background and Purpose- There are limited data on intravenous thrombolysis treatment in patients with ischemic stroke who have received prophylactic doses of low molecular weight heparins (LMWHs). We aimed to evaluate the safety and outcomes of intravenous thrombolysis treatment in stroke patients taking thromboprophylactic doses of LMWH. Methods- We analyzed 109 291patients treated with intravenous thrombolysis, recorded in the Safe Implementation of Treatments in Stroke International Thrombolysis Register between 2003 and 2017 not taking oral anticoagulants or therapeutic doses of heparin at stroke onset. One thousand four hundred eleven patients (1.3%) were on prophylactic LMWH for deep venous thrombosis prevention. Outcome measures were symptomatic intracerebral hemorrhage, parenchymal hematoma, death within 7 days and 3 months, and functional dependency at 3 months. Results- Patients on LMWH were older, had more severe strokes, more prestroke disability, and comorbidities than patients without LMWH. There was no significant increase in adjusted odds ratios (aOR) for symptomatic intracerebral hemorrhage (aOR, 1.02 [95% CI, 0.48-2.17] as per Safe Implementation of Treatments in Stroke -MOST, aOR, 0.95 [0.59-1.53] per ECASS II]), nor for 7-day mortality (aOR, 1.14 [0.82-1.59]), in the prophylactic LMWH group. The LMWH group had a higher aOR for 3-month mortality (aOR, 1.94 [1.49-2.53]) and functional dependency, aOR, 1.44 (1.10-1.90). Propensity score analysis matching patients on baseline characteristics removed differences between groups on all outcomes except 3-month mortality. Conclusions- Intravenous thrombolysis in patients with acute ischemic stroke on treatment with prophylactic doses of LMWH at stroke onset is not associated with an increased risk of symptomatic intracerebral hemorrhage or early death.

MeSH
antikoagulancia aplikace a dávkování MeSH
cévní mozková příhoda diagnóza farmakoterapie mortalita MeSH
heparin nízkomolekulární aplikace a dávkování MeSH
intravenózní podání MeSH
lidé MeSH
preexpoziční profylaxe metody MeSH
senioři MeSH
trombolytická terapie metody mortalita trendy MeSH
výsledek terapie MeSH
Check Tag
lidé MeSH
mužské pohlaví MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
multicentrická studie MeSH
pozorovací studie MeSH
práce podpořená grantem MeSH

Článek

Tichý akútny a subakútny mozgový infarkt u pacientov pred koronárnou intervenciou
[Acute and subacute silent cerebral infarction in patients before elective coronary intervention]

Česká a slovenská neurologie a neurochirurgie. 2018 ; 81 (5) : 563-569.

ISSN 1210-7859
Medvik
Zdroj

Úvod: Tichý mozgový infarkt (silent cerebral infarction; SCI) sa považuje za rizikový faktor postupného rozvoja kognitívnej dysfunkcie, psychiatrických ochorení, vzniku CMP a skoršej mortality. Presná incidencia a prevalencia SCI nie je známa a líši sa na základe výsledkov publikovaných klinických štúdií. Cieľom našej práce bolo zistiť výskyt incidentálnych akútnych a subakútnych SCI na MR mozgu a ich objem u pacientov pred plánovanou koronárnou intervenciou, ako aj posúdiť rizikové faktory vzniku SCI. Materiál a metodika: Do štúdie boli zaradení pacienti pred elektívnou koronárnou angiografiou, angioplastikou alebo stentingom. Pred intervenciou absolvovali MR mozgu, na ktorom sa hodnotila prítomnosť akútneho a subakútneho SCI, jeho objem a vzťah jednotlivých rizikových faktorov k výskytu SCI. Zároveň sa hodnotil kognitívny deficit vo vzťahu k SCI. Výsledky: Do štúdie bolo od novembra 2015 do júla 2017 zaradených 144 pacientov (103 mužov a 41 žien). Zo 144 pacientov malo prítomný minimálne jeden akútny/subakútny SCI na MR pred koronárnou intervenciou 9 (6,3 %) pacientov. Jediným štatisticky významným rizikovým faktorom prítomnosti SCI bol vyšší výskyt prekonanej CMP/tranzitórneho ischemického ataku (TIA) v minulosti (p = 0,05). U jednej pacientky bola diagnostikovaná ipsilaterálna stenóza arteria carotis interna > 50 %. Objem mozgových ischemických ložísk bol väčší u pacientov s prekonanou CMP/TIA v anamnéze (p = 0,008). Vyšetrenie kognitívnych testov nepotvrdilo štatisticky významné rozdiely medzi pacientami s SCI a pacientami bez SCI (p > 0,05). Záver: U pacientov indikovaných k elektívnej koronárnej intervencii sa vyskytoval akútny/subakútny SCI v 6,3 %. Ako rizikový faktor prítomnosti a zároveň väčšieho objemu ischemických ložísk sa preukázala anamnéza prekonanej CMP/TIA. Štúdia nepotvrdila štatisticky významný kognitívny deficit u pacientov s SCI oproti pacientom bez SCI.

Introduction: The presence of silent cerebral infarction (SCI) might cause cognitive dysfunction, psychiatric disorders, stroke and earlier mortality. Exact incidence and prevalence of SCI is still not known, the results of previously published clinical trials vary. The aims of our study were to detect acute and subacute SCI using MRI in patients before elective coronary intervention, measure the volume of SCI and investigate the risk factors associated with SCI. Materials and methods: Patients indicated for elective coronary angiography, angioplasty or stenting were enrolled in this study. Brain MRI was performed before cardiac intervention. The presence of acute and subacute SCI was evaluated, SCI volume was measured and risk factors associated with SCI were investigated. Cognitive functions were tested and correlated with SCI. Results: Between November 2015 and July 2017, 144 patients were enrolled in the study (103 men, 41 women). At least one acute/subacute SCI was detected on MRI in 9 out of 144 (6.3%) patients before cardiac intervention. History of stroke or transient ischemic attack (TIA) was associated with a higher risk of SCI (p = 0.05). Ipsilateral internal carotid artery stenosis > 50% was diagnosed in one patient. Patients with a history of stroke/TIA had a larger volume of SCI (p = 0.008). We did not find stastistically significant differences in cognitive function tests between patients with SCI and without SCI (p > 0.05). Conclusion: Acute/subacute SCI was detected in 6.3% of patients indicated for elective coronary intervention. History of stroke or TIA was a predictor of the presence of SCI and also its volume. No correlation was found between SCI and cognitive dysfunction.

MeSH
cévní mozková příhoda MeSH
kognitivní dysfunkce MeSH
koronární angiografie MeSH
lidé MeSH
magnetická rezonanční tomografie MeSH
mozkový infarkt * diagnostické zobrazování etiologie MeSH
rizikové faktory MeSH
Check Tag
lidé MeSH
Publikační typ
práce podpořená grantem MeSH

Článek

Agresívna liečba intracerebrálnej hemoragie so znižovaním krvného tlaku a indikáciou operácie - komentář

Brozman, Miroslav
Autor Autorita Neurologická klinika FN a UKF Nitra

Česká a slovenská neurologie a neurochirurgie. 2018 ; 81 (4) : 394.

ISSN 1210-7859
Medvik
Zdroj

Publikační typ
komentáře MeSH

Článek

Sonolysis in risk reduction of symptomatic and silent brain infarctions during coronary stenting (SONOREDUCE): Randomized, controlled trial

International journal of cardiology. 2018 ; 267 (-) : 62-67. [pub] 20180526

Int J Cardiol
ISSN 1874-1754
Medvik
Zdroj

BACKGROUND: Silent brain infarcts can be detected on magnetic resonance imaging (MRI) in ~22% of patients after coronary angioplasty and stenting (CS). The effect of periprocedural sonolysis on the risk of new brain infarcts during CS was examined. METHODS: Patients undergoing elective CS were allocated randomly to a bilateral sonolysis group (70 patients, 58 men; mean age, 59.9 years) or a control group (74 patients, 45 men; mean age, 65.5 years). Neurologic examination, cognitive function tests, and brain MRI were performed prior to intervention and at 24 h after CS. Neurologic examination and cognitive function tests were repeated at 30 days after CS. RESULTS: No significant differences were observed in the number of patients with new infarcts (25.7 vs. 18.9%, P = 0.423), the number of lesions (1.3 ± 1.0 vs. 2.9 ± 5.3, P = 0.493), lesion volume (0.16 ± 0.34 vs. 0.28 ± 0.60 mL, P = 0.143), and the number of patients with new ischemic lesions in the insonated MCA territories (18.6vs. 17.6%, P = 0.958) between the sonolysis group and the control group. There were no cases of stroke, transient ischemic attack, myocardial infarction, or death in the two groups. Intracranial bleeding was reported only in 1 patient in the control group (0 vs. 1.4%, P = 0.888). Clock-drawing test scores at 30 days were significantly higher in the sonolysis group than in the control group (median 3.0 vs. 2.5, P = 0.031). CONCLUSIONS: Sonolysis does not reduce the risk of new brain infarcts after CS. The effect of sonolysis on number and volume of ischemic lesions and cognitive function should be assessed in further studies.

Abstrakt

Progresívna multifokálna leukoencefalopatia u pacienta so systémovým lupus erythematodes na biologickej liečbe

Česká revmatologie. 2018 ; 26 (3) : 199. (Abstrakta 62. sjezdu českých a slovenských revmatologů 20.-22. září 2018, Kongresový hotel Clarion, Praha)

ISSN 1210-7905
Medvik
Zdroj

Publikační typ
abstrakt z konference MeSH

Článek

Interleukin 6 and complement serum level study in Parkinson's disease

Journal of neural transmission. 2018 ; 125 (5) : 875-881. [pub] 20180212

J Neural Transm
ISSN 1435-1463
Medvik
Zdroj

The objective of this study is to assess whether elevation of serum inflammatory markers levels may indicate the progression of clinical impairment in Parkinson's disease (PD) patients. In 47 PD patients, the serum levels of the C3 and C4 part of the complement and Interleukin-6 (IL-6) were measured. The results at baseline and after 2 years were correlated with scales measuring memory, depression, motor symptoms, and quality of life. Patients with higher levels of C3 and C4 at baseline had decreased quality of life, verbal ability, and memory. Patients with higher IL-6 at baseline showed worse depression scores at 2 years. Patients with persistently higher levels of C3 and C4 at 2 years had worse quality of life and memory ability. Uncorrected p values are reported due to the exploratory nature of the study. The results indicate an impact of inflammation on non-motor signs and quality of life in PD. The increase of levels of serum inflammatory biomarkers may indicate the progression of non-motor impairment in PD.

Abstrakt

Idiopatická brachiálna plexopatia - kazuistika

Česká a slovenská neurologie a neurochirurgie. 2018 ; 81 (6) : 718-719. (Abstrakta přednášek, které odezněly na XI. neuromuskulárním kongresu Brno, 10.–11. května 2018)

ISSN 1210-7859
Medvik
Zdroj

Publikační typ
abstrakt z konference MeSH

Článek

Intravenous thrombolysis for ischemic stroke in the golden hour: propensity-matched analysis from the SITS-EAST registry

Journal of neurology. 2017 ; 264 (5) : 912-920. [pub] 20170318

J Neurol
ISSN 1432-1459
Medvik
Zdroj

As there are scarce data regarding the outcomes of acute ischemic stroke (AIS) patients treated with intravenous thrombolysis (IVT) within 60 min from symptom onset ("golden hour"), we sought to compare outcomes between AIS patients treated within [GH(+)] and outside [GH(-)] the "golden hour" by analyzing propensity score matched data from the SITS-EAST registry. Clinical recovery (CR) at 2 and 24 h was defined as a reduction of ≥10 points on NIHSS-score or a total NIHSS-score of ≤3 at 2 and 24 h, respectively. A relative reduction in NIHSS-score of ≥40% at 2 h was considered predictive of complete recanalization (CREC). Symptomatic intracranial hemorrhage (sICH) was defined using SITS-MOST criteria. Favorable functional outcome (FFO) was defined as a mRS-score of 0-1 at 3 months. Out of 19,077 IVT-treated AIS patients, 71 GH(+) patients were matched to 6882 GH(-) patients, with no differences in baseline characteristics (p > 0.1). GH(+) had higher rates of CR at 2 (31.0 vs. 12.4%; p < 0.001) and 24 h (41 vs. 27%; p = 0.010), CREC at 2 h (39 vs. 21%; p < 0.001) and FFO (46.5 vs. 34.0%; p = 0.028) at 3 months. The rates of sICH and 3-month mortality did not differ (p > 0.2) between the two groups. GH(+) was associated with 2-h CR (OR: 5.34; 95% CI 2.53-11.03) and CREC (OR: 2.38; 95% CI 1.38-4.09), 24-h CR (OR: 1.88; 95% CI 1.08-3.26) and 3-month FFO (OR: 2.02; 95% CI 1.15-3.54) in multivariable logistic regression models adjusting for potential confounders. In conclusion, AIS treated with IVT within the GH seems to have substantially higher odds of early neurological recovery, CREC, 3-month FFO and functional improvement.

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