This paper deals with a facile fabrication of self-crosslinking acrylic latex coating binders comprising embedded nanoparticles originated from ZnO in the role of biocide agent. The incorporation of nanostructured ZnO was performed during the latex synthesis carried out by a semi-continuous emulsion polymerization technique. For the covalent self-crosslinking, diacetone acrylamide was copolymerized into the polymer to provide sites for the subsequent reaction with adipic acid dihydrazide. The latex storage stability and coating performance were assessed with respect to the concentration of incorporated nanoparticles (0.5–2 wt.% based on monomers). It was found that all coating binder compositions containing inorganic nanoparticles exhibited a long-term shelf-life stability and provided crosslinked smooth transparent coating films of high gloss. The binder compositions synthesized using 1–2 wt.% of nanostructured ZnO (related to monomers) provided coatings with enhanced solvent resistance and bacteriostatic effect.
The Letter describes the preparation and characterization of a conjugate of isoniazid (INH) with magnetic nanoparticles Fe3O4@SiO2 115±60 nm in size. The INH molecules were attached to the surface of nanoparticles by a covalent pH-sensitive amidine bond. The conjugate was characterized by X-ray diffraction, SEM, dynamic light scattering, IR spectroscopy and microanalysis. The conjugate released isoniazid under in vitro conditions (pH=4; 37 °C; t1/2≈115 s). In addition, the cytotoxicity of the Fe3O4@SiO2-INH conjugate was evaluated in SK-BR-3 cells using the xCELLigence system.
- MeSH
- antibakteriální látky chemická syntéza chemie toxicita MeSH
- difrakce rentgenového záření MeSH
- isoniazid chemická syntéza chemie toxicita MeSH
- koncentrace vodíkových iontů MeSH
- kultivované buňky MeSH
- magnetismus * MeSH
- mikroskopie elektronová rastrovací MeSH
- nanočástice chemie MeSH
- oxid křemičitý chemie MeSH
- proliferace buněk účinky léků MeSH
- železité sloučeniny chemie MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
