The aim of this paper was to summarise knowledge of IL-22 involvement in multiple sclerosis (MS) and the possible link between IL-22 and two transcription factors - AHR and c-Maf. The conclusion is that despite numerous studies, the exact role of IL-22 in the pathogenesis of MS is still unknown. The expression and function of c-Maf in MS have not been studied. It seems that the functions of c-Maf and AHR are at least partly connected with IL-22, as both directly or indirectly influence the regulation of IL-22 expression. This possible connection has never been studied in MS.
- MeSH
- adaptorové proteiny signální transdukční fyziologie MeSH
- interleukiny fyziologie MeSH
- lidé MeSH
- receptory aromatických uhlovodíků fyziologie MeSH
- roztroušená skleróza etiologie MeSH
- transkripční faktory bHLH fyziologie MeSH
- transkripční faktory fyziologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH