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The role of interleukin 22 in multiple sclerosis and its association with c-Maf and AHR

M. K. Zarobkiewicz, W. Kowalska, M. Slawinski, J. Rolinski, A. Bojarska-Junak

. 2019 ; 163 (3) : 200-206. [pub] 20190604

Language English Country Czech Republic

Document type Journal Article, Review

Persistent link   https://www.medvik.cz/link/bmc20005459

The aim of this paper was to summarise knowledge of IL-22 involvement in multiple sclerosis (MS) and the possible link between IL-22 and two transcription factors - AHR and c-Maf. The conclusion is that despite numerous studies, the exact role of IL-22 in the pathogenesis of MS is still unknown. The expression and function of c-Maf in MS have not been studied. It seems that the functions of c-Maf and AHR are at least partly connected with IL-22, as both directly or indirectly influence the regulation of IL-22 expression. This possible connection has never been studied in MS.

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