The present work highlights recent achievements in development of nanostructured dispersions and biocolloids for drug delivery applications. We emphasize the key role of biological small-angle X-ray scattering (BioSAXS) investigations for the nanomedicine design. A focus is given on controlled encapsulation of small molecular weight phytochemical drugs in lipid-based nanocarriers as well as on encapsulation of macromolecular siRNA, plasmid DNA, peptide and protein pharmaceuticals in nanostructured nanoparticles that may provide efficient intracellular delivery and triggered drug release. Selected examples of utilisation of the BioSAXS method for characterization of various types of liquid crystalline nanoorganizations (liposome, spongosome, cubosome, hexosome, and nanostructured lipid carriers) are discussed in view of the successful encapsulation and protection of phytochemicals and therapeutic biomolecules in the hydrophobic or the hydrophilic compartments of the nanocarriers. We conclude that the structural design of the nanoparticulate carriers is of crucial importance for the therapeutic outcome and the triggered drug release from biocolloids.
- MeSH
- antitumorózní látky chemie farmakologie MeSH
- difrakce rentgenového záření MeSH
- fytonutrienty chemie farmakologie MeSH
- hydrofobní a hydrofilní interakce MeSH
- koloidy MeSH
- lidé MeSH
- malá interferující RNA genetika metabolismus MeSH
- maloúhlový rozptyl MeSH
- nanočástice chemie MeSH
- nosiče léků * MeSH
- peptidy chemie metabolismus MeSH
- plazmidy chemie metabolismus MeSH
- příprava léků metody MeSH
- uvolňování léčiv MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
