The threat of a worldwide influenza pandemic has greatly increased over the past decade with the emergence of highly virulent avian influenza strains. The increased frequency of drug-resistant influenza strains against currently available antiviral drugs requires urgent development of new strategies for antiviral therapy, too. The research in the field of therapeutic peptides began to develop extensively in the second half of the 20(th) century. Since then, the mechanisms of action for several peptides and their antiviral prospect received large attention due to the global threat posed by viruses. Here, we discussed the therapeutic properties of peptides used in influenza treatment. Peptides with antiviral activity against influenza can be divided into three main groups. First, entry blocker peptides such as a Flupep that interact with influenza hemagglutinin, block its binding to host cells and prevent viral fusion. Second, several peptides display virucidal activity, disrupting viral envelopes, e.g., Melittin. Finally, a third set of peptides interacts with the viral polymerase complex and act as viral replication inhibitors such as PB1 derived peptides. Here, we present a review of the current literature describing the antiviral activity, mechanism and future therapeutic potential of these influenza antiviral peptides.
- MeSH
- antivirové látky farmakologie terapeutické užití MeSH
- chřipka lidská farmakoterapie MeSH
- infekce viry z čeledi Orthomyxoviridae farmakoterapie MeSH
- internalizace viru účinky léků MeSH
- klinické zkoušky jako téma MeSH
- lidé MeSH
- modely nemocí na zvířatech MeSH
- objevování léků trendy MeSH
- Orthomyxoviridae účinky léků fyziologie MeSH
- peptidy farmakologie terapeutické užití MeSH
- replikace viru účinky léků MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- MeSH
- elektronová mikroskopie MeSH
- mikrobiologie MeSH
- virologie * MeSH
- Publikační typ
- biografie MeSH
- O autorovi
- Čiampor, Fedor, 1942- Autorita