We describe 12 cases of leiomyoma with intracytoplasmic inclusion bodies, which were detected in a group of 447 leiomyomas examined at our institution between December 2005 and March 2006. Ten of these tumors were typical leiomyomas, and two cases represented atypical (bizarre) leiomyoma. In some cases, the presence of intracytoplasmic inclusion bodies resulted in a rhabdoid or skeletal muscle-like appearance of the tumor cells. Ultrastructurally, there were two types of inclusions. One of them consisted of an abnormal aggregation of intermediate and actin filaments. Another type of inclusions was composed of dense granular material without an apparent fibrillar structure. The ultrastructure of the inclusions correlates with immunohistochemical and histochemical stainings. The inclusions with apparent fibrillar arrangements were PAS negative, stained red by trichrome, and were, at least at the periphery, actin-, desmin-, and h-caldesmon-positive. The dense granular inclusions were at least focally PAS-positive, stained red by trichrome, and were negative immunohistochemically. The intracytoplasmic inclusions were found in atypical (bizarre) leiomyomas of the uterus and occasionally in epithelioid leiomyomas and leiomyosarcomas. However, to the best of our knowledge, these inclusions have not been found in typical uterine leiomyomas to date.
- MeSH
- aktiny analýza MeSH
- azosloučeniny MeSH
- biologické markery analýza MeSH
- buněčná inkluze chemie ultrastruktura MeSH
- desmin analýza MeSH
- diferenciální diagnóza MeSH
- dospělí MeSH
- eosin MeSH
- financování organizované MeSH
- imunohistochemie metody MeSH
- keratiny analýza MeSH
- leiomyom diagnóza chemie ultrastruktura MeSH
- lidé středního věku MeSH
- lidé MeSH
- methylová zeleň MeSH
- MyoD Protein analýza MeSH
- myogenin analýza MeSH
- nádory dělohy diagnóza chemie ultrastruktura MeSH
- proteiny vázající kalmodulin analýza MeSH
- rhabdoidní nádor patologie MeSH
- Schiffova reakce MeSH
- senioři MeSH
- vimentin analýza MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři MeSH
- ženské pohlaví MeSH
- MeSH
- artroplastiky kloubů * metody využití MeSH
- autoradiografie * metody využití MeSH
- experimenty na zvířatech MeSH
- glykosaminoglykany izolace a purifikace metabolismus MeSH
- histocytochemie * metody využití MeSH
- histologické techniky metody využití MeSH
- kloubní chrupavka chirurgie MeSH
- psi MeSH
- radius chemie transplantace MeSH
- rentgendiagnostika využití MeSH
- Schiffova reakce metody využití MeSH
- statistika jako téma MeSH
- zvířata MeSH
- Check Tag
- psi MeSH
- zvířata MeSH
