Since the 1960s, more than 350,000 new chemicals have been introduced into the lives of humans and domestic animals. Many of them have become part of modern life and some are affecting nature as pollutants. Yet, our comprehension of their potential health risks for both humans and animals remains partial. The "epithelial barrier theory" suggests that genetic predisposition and exposure to diverse factors damaging the epithelial barriers contribute to the emergence of allergic and autoimmune conditions. Impaired epithelial barriers, microbial dysbiosis, and tissue inflammation have been observed in a high number of mucosal inflammatory, autoimmune and neuropsychiatric diseases, many of which showed increased prevalence in the last decades. Pets, especially cats and dogs, share living spaces with humans and are exposed to household cleaners, personal care products, air pollutants, and microplastics. The utilisation of cosmetic products and food additives for pets is on the rise, unfortunately, accompanied by less rigorous safety regulations than those governing human products. In this review, we explore the implications of disruptions in epithelial barriers on the well-being of companion animals, drawing comparisons with humans, and endeavour to elucidate the spectrum of diseases that afflict them. In addition, future research areas with the interconnectedness of human, animal, and environmental well-being are highlighted in line with the "One Health" concept.
- MeSH
- domácí zvířata * imunologie MeSH
- epitel imunologie MeSH
- kočky MeSH
- lidé MeSH
- psi MeSH
- vystavení vlivu životního prostředí škodlivé účinky MeSH
- zvířata MeSH
- Check Tag
- kočky MeSH
- lidé MeSH
- psi MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
V súvislosti s neustále stúpajúcou prevalenciou alergicky podmienených ochorení vo svete sa do popredia dostávajú možnosti ich prevencie vzniku a progresie. Jedným z častých faktorov zhoršenej kontroly alergickej rinokonjuktivitídy a bronchiálnej astmy u predisponovaných jedincov s atopiou je senzibilizácia na alergény zvierat. Mačka domáca je častým domácim maznáčikom. V rámci terciárnej prevencie symptómov a progresie ochorení u senzibilizovaných pacientov je dôležité v týchto prípadoch zamedziť, respektíve obmedziť expozíciu zvieracím alergénom. V mnohých prípadoch však odstránenie zvieraťa z domácnosti nie je možné vzhľadom na úzku citovú väzbu a náklonnosť členov domácnosti. V rámci redukcie expozície mačacím aeroalergénom vzduchová filtrácia ako jedna z režimových modalít môže prispieť k lepšej kontrole a redukcii symptómov alergikov.
In connection with constantly increasing prevalence of allergic dependent diseases more attention is focused on the options of preventability and progression of these diseases. Sensibilisation on animal dander in predisposed atopic individuals is one of the most common factors of losing control in allergic rhinoconjunctivitis and bronchial asthma. The domestic cat is a popular pet in many households. Measures to prevent or limit exposure to animal allergens are important in tertial prevention of symptoms and progression of associated diseases in sensitized patients. In many cases is to get rid out of animal from household very difficult due to the strong and close emotional attachment as well as the affection of the family members. Air filtration as an option to therapeutic management of allergic person sensitized to cat allergens can lead to a better control and symptom reduction of associated allergic diseases.
- MeSH
- alergeny * MeSH
- domácí zvířata imunologie MeSH
- filtrace MeSH
- kočky imunologie MeSH
- lidé MeSH
- vzduchové filtry MeSH
- Check Tag
- kočky imunologie MeSH
- lidé MeSH
Adverse food reactions occur in human as well as veterinary patients. Systematic comparison may lead to improved recommendations for prevention and treatment in both. In this position paper, we summarize the current knowledge on immediate-type food allergy vs other food adverse reactions in companion animals, and compare this to the human situation. While the prevalence of food allergy in humans has been well studied for some allergens, this remains to be investigated for animal patients, where owner-reported as well as veterinarian-diagnosed food adverse reactions are on the increase. The characteristics of the disease in humans vs dogs, cats, and horses are most often caused by similar, but sometimes species-dependent different pathophysiological mechanisms, prompting the specific clinical symptoms, diagnoses, and treatments. Furthermore, little is known about the allergen molecules causative for type I food allergy in animals, which, like in human patients, could represent predictive biomarkers for risk evaluation. The definite diagnosis of food allergy relies-as in humans-on elimination diet and provocation tests. Besides allergen avoidance in daily practice, novel treatment options and tolerization strategies are underway. Taken together, numerous knowledge gaps were identified in veterinary food allergy, which need to be filled by systematic comparative studies.
- MeSH
- časná přecitlivělost diagnóza veterinární MeSH
- domácí zvířata imunologie MeSH
- kočky MeSH
- koně MeSH
- lidé MeSH
- potravinová alergie diagnóza veterinární MeSH
- psi MeSH
- zvířata MeSH
- Check Tag
- kočky MeSH
- lidé MeSH
- psi MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
