- MeSH
- infekce dýchací soustavy imunologie MeSH
- interleukin-17 imunologie MeSH
- lidé MeSH
- organoidy imunologie MeSH
- plíce imunologie MeSH
- receptory interleukinu-17 imunologie MeSH
- respirační sliznice imunologie MeSH
- signální transdukce MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
The interleukin 17 (IL-17) cytokine and receptor family is central to antimicrobial resistance and inflammation in the lung. Mice lacking IL-17A, IL-17F, or the IL-17RA subunit were compared with wild-type mice for susceptibility to airway inflammation in models of infection and allergy. Signaling through IL-17RA was required for efficient microbial clearance and prevention of allergy; in the absence of IL-17RA, signaling through IL-17RC on epithelial cells, predominantly by IL-17F, significantly exacerbated lower airway Aspergillus or Pseudomonas infection and allergic airway inflammation. In contrast, following infection with the upper respiratory pathogen Staphylococcus aureus, the IL-17F/IL-17RC axis mediated protection. Thus, IL-17A and IL-17F exert distinct biological effects during pulmonary infection; the IL-17F/IL-17RC signaling axis has the potential to significantly worsen pathogen-associated inflammation of the lower respiratory tract in particular, and should be investigated further as a therapeutic target for treating pathological inflammation in the lung.
- MeSH
- alergie genetika imunologie mikrobiologie patologie MeSH
- Aspergillus imunologie MeSH
- aspergilóza genetika imunologie mikrobiologie patologie MeSH
- epitelové buňky imunologie mikrobiologie patologie MeSH
- interleukin-17 nedostatek genetika imunologie MeSH
- lidé MeSH
- modely nemocí na zvířatech MeSH
- myši inbrední C57BL MeSH
- myši knockoutované MeSH
- myši MeSH
- náchylnost k nemoci MeSH
- plíce imunologie mikrobiologie patologie MeSH
- protein - isoformy nedostatek genetika imunologie MeSH
- pseudomonádové infekce genetika imunologie mikrobiologie patologie MeSH
- Pseudomonas imunologie MeSH
- receptory interleukinu-17 nedostatek genetika imunologie MeSH
- regulace genové exprese MeSH
- respirační sliznice imunologie mikrobiologie patologie MeSH
- signální transdukce MeSH
- stafylokokové infekce genetika imunologie mikrobiologie patologie MeSH
- Staphylococcus aureus imunologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
