The aim of the study was to examine the prevalence and type of medicines used by high school students in the Czech Republic and to analyze association between use of medicines during last 6 months and self medication with different socio-demographic and lifestyle aspects. A cross-sectional study was conducted in high schools from two regions and three towns in the Czech Republic. The study sample was a student population of nine selected high schools. The study was approved by the local Ethics Committees and school board and was conducted in compliance with the ethical principles of the Declaration of Helsinki. Questionnaires respecting anonymity were distributed to the students during the regular class period. Students answered closed and open questions divided into six sections focussing on their experience with chronic and irregular use of medicines, medicines use during last six months, conditions treated, type and source of used medicines. A modified log-linear Poisson regression model with a robust variance estimator (sandwich) was used for statistical analysis. In total, 979 students, aged 14-21 years (mean age 17 years) participated in the study: 32% were male and 68% female; 19% of students reported regular use of medicines for chronic disease. The use of medicines during the last 6 months was reported by 83% of students; 42% of them reported the use of both prescription and over the counter (OTC) medicines; 22% the use only of OTC, and 31% only prescription medicines. Allergy, asthma, disorders of the thyroid gland, atopic dermatitis, and hypertensive diseases were among the most frequent long-term diseases. The most frequent groups of medicines used for the treatment of long-term diseases were systemic antihistamines, thyroid preparations, and respiratory drugs. Nonsteroidal anti-inflammatory medicines, ibuprofen and paracetamol were the most frequently used medicines during last six months. The study results showed quite extensive use of both prescription and OTC medicines in students of high schools between 14-21 years of age in the Czech Republic. Statistically significant associations were found between use of medicines during last 6 months and type of school, sex and chronic diseases, and between self-medication and sex.
- MeSH
- dospělí MeSH
- farmakoterapie * MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- Poissonovo rozdělení MeSH
- průřezové studie MeSH
- samoléčba statistika a číselné údaje MeSH
- studenti MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
- Publikační typ
- abstrakt z konference MeSH
- Publikační typ
- abstrakt z konference MeSH
OBJECTIVE: The aim of this study was to assess the situation regarding spontaneous adverse drug reaction reporting in the Czech Republic during a 5-year period (2005-2009). SETTING: Descriptive study was conducted using the data from the Czech State Institute for Drug Control pharmacovigilance database. METHODS: The data referring to all spontaneous adverse drug reaction reports received, by the pharmacovigilance department of the Czech State Institute for Drug Control during 2005-2009 were collected, analysed and compared with data from the Slovak Republic, Denmark, and the United Kingdom. MAIN OUTCOME MEASURES: The number of received spontaneous adverse drug reactions reports by year per 10,000 inhabitants, the seriousness and outcome of reactions, the reporting groups, and the top ten molecules which contributed to the highest number of reports. RESULTS: During the study period 2005-2009, the pharmacovigilance department of the State Institute for Drug Control received 7,708 spontaneous adverse drug reactions reports of which 73.6% were serious and 2.1% resulted in death. The number of spontaneous adverse drug reactions reports per 10,000 inhabitants ranged from 1.3 to 1.7, which was lower when compared with the number of reports from three other EU countries. The healthcare professionals contributed to 64.2% of the adverse drug reactions reports, whilst marketing authorization holders provided 35.5%, and finally patients with 0.3%. Vaccines, ketoprofen, amoxicillin, statins, and estradiol were amongst the top ten molecules that gave the highest number of spontaneous adverse drug reactions reports. CONCLUSIONS: Our assessment of adverse drug reactions spontaneous reports received by the Czech Institute for Drug Control during 2005-2009 showed that the reporting rate is relatively low and remains constant over the 5 year period. More emphasis on academic/professional training is needed to educate all potential reporters on the mechanism of reporting of adverse drug reactions and to also emphasize the importance of the whole pharmacovigilance process.
- MeSH
- databáze faktografické normy trendy MeSH
- lidé MeSH
- nežádoucí účinky léčiv diagnóza epidemiologie MeSH
- systémy pro sběr zpráv o nežádoucích účincích léků normy trendy MeSH
- zdravotnický personál normy trendy MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Geografické názvy
- Česká republika MeSH
- Klíčová slova
- SANDIMMUN NEORAL,
- MeSH
- cyklosporin aplikace a dávkování MeSH
- klinické protokoly MeSH
- lidé MeSH
- pacienti MeSH
- transplantace srdce MeSH
- Check Tag
- lidé MeSH
