BACKGROUND: The aim of study, which was supported by grant IGA MZ CR NR 7814-3, was to determine sensitivity of serum tests APRI, test of liver fibrosis according Forns and alpha2macroglobulin in detection of liver fibrosis. METHODS AND RESULTS: The cohort study included 30 patients with chronic hepatitis C, all were infected HCV genotype 1a or 1b. Liver biopsy specimen was evaluated by one pathologist and liver fibrosis was classified according Battes-Ludwig. CONCLUSIONS: Statistically significant correlation of APRI and alpha2macroglobulin with the stage of fibrosis was identified; while there was no statistically significant sensitivity of Forns test of liver fibrosis.

• MeSH
• alfa-makroglobuliny analýza   MeSH
• aspartátaminotransferasy krev   MeSH
• biologické markery krev   MeSH
• chronická hepatitida C komplikace   MeSH
• dospělí MeSH
• jaterní cirhóza diagnóza   patologie   virologie   MeSH
• játra patologie   MeSH
• jehlová biopsie MeSH
• lidé MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• Názvy látek
• alfa-makroglobuliny MeSH
• aspartátaminotransferasy MeSH
• biologické markery MeSH

The chronic course of idiopathic intestinal inflammations is characterized also by a relatively high incidence of complications, local ones affecting the entire large intestine, as well as extraintestinal ones in remote organs. In the submitted paper the authors present the results of a six-year follow-up focused on the incidence of dysplastic changes of the intestinal mucosa and colorectal carcinoma in 46 patients from a group of 220 patients followed up on a long-term basis at the Second Medical Clinic of the Faculty Hospital and Medical Faculty Olomouc because of the extensive type of ulcerative colitis. The incidence of these complications is not high in our group and is only slightly higher than in the general population. As it is however a very serious disease and so far an optimal algorithm for its follow up has not been elaborated, we feel it is useful to investigate this high risk group of patients after 6-24-month intervals according to the confirmed grade of dysplasia of the intestinal mucosa.

• MeSH
• dospělí MeSH
• karcinom etiologie   patologie   MeSH
• kolorektální nádory etiologie   patologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• prekancerózy diagnóza   patologie   MeSH
• prospektivní studie MeSH
• senioři MeSH
• střevní sliznice patologie   MeSH
• ulcerózní kolitida komplikace   patologie   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH

The author describes a case of early onset of asymptomatic renal insufficiency in a young patient with ulcerative colitis, treated by large doses of mesalazine. After discontinuation of the drug rapid restoration of renal functions occurred. Contrary to all hitherto published cases, this patient developed renal failure very soon. Urea serum levels reached pathological values after 27 days and the creatinine level already 15 days after the onset of mesalazine administration. The renal affection was unequivocally confirmed by examination of the urine (semiquantitative and quantitative) and dynamic functional scintigraphy.

• MeSH
• antiflogistika nesteroidní aplikace a dávkování   škodlivé účinky   MeSH
• dospělí MeSH
• lidé MeSH
• mesalamin aplikace a dávkování   škodlivé účinky   MeSH
• renální insuficience chemicky indukované   MeSH
• ulcerózní kolitida farmakoterapie   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• antiflogistika nesteroidní MeSH
• mesalamin MeSH

The author investigated in a group of 224 patients selected at random (380 extremities), indicated for different reasons for examination of the venous system of the lower extremities by coloured duplex and triplex sonography, the prevalence, site and clinical manifestations of deep venous insufficiency. Only 21.1% patients indicated for examination on account of clinical signs of deep venous thrombosis had objective signs of the disease, while almost half (47.7%) suffered from venous insufficiency. Venous insufficiency was detected also in a large percentage (59.9%) of patients without clinical symptoms. In the great majority of patients (99.8%) combined insufficiency was found affecting concurrently the femoral and popliteal vein and sometimes also the iliac vein.

• MeSH
• chronická nemoc MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ultrasonografie MeSH
• žilní insuficience komplikace   diagnóza   diagnostické zobrazování   MeSH
• žilní trombóza komplikace   diagnóza   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

The submitted prospective randomized study investigated the way and rate of regression of deep venous thrombosis of the lower extremities during a six-month out-patient follow up. On discharge on the 5th to 10th day after establishment of the diagnosis the thrombosis had not disappeared in any of the patients, in two patients progression was observed despite anticoagulant therapy. After three months 4.8% thromboses were recanalized, after 6 months 33.3%. In 33.3% of patients recanalization in a distal-proximal direction was found, in 19% in a proximal-distal direction and in 33.3% recanalization occurred throughout the thrombotic occlusion. Thromboses recanalized more quickly in patients under 50 years of age.

• MeSH
• antikoagulancia terapeutické užití   MeSH
• lidé středního věku MeSH
• lidé MeSH
• následné studie MeSH
• prospektivní studie MeSH
• ultrasonografie dopplerovská barevná MeSH
• žilní trombóza diagnostické zobrazování   farmakoterapie   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• klinické zkoušky MeSH
• randomizované kontrolované studie MeSH
• Názvy látek
• antikoagulancia MeSH