Selenium deficiency is a common nutritional disorder in dairy cattle globally. However, selenium supplementation can lead to selenium toxicity. This study evaluated a novel, low-toxicity selenium supplement, selenitetriglycerides, to determine its efficacy and safety in dairy cows. The study was conducted on 12 Holstein Friesian cows divided in two equal groups (control group without supplementation of selenium and experimental group with supplementation of selenitetriglycerides). Experimental cows (n=6) were orally administered 300 mg/cow/day of selenitetriglycerides for 14 days (days 1-14) and then monitored for a further 14 days (days 15-28). Blood from both groups of cows was sampled for determination of selenium concentrations, activity of aspartate aminotransferase, creatine kinase, lactate dehydrogenase, gamma- -glutamyl transferase, concentrations of triglycerides, cholesterol, non-esterified fatty acids, glucose, total protein, urea, creatinine and hematological parameters. Serum selenium concentrations in the experimental group increased significantly on day 2 (from 64.92±6.89 μg/L to 127.95±13.75 μg/L), peaked on day 7 (266.22±14.21 μg/L) and remained significantly above the initial baseline values (day 1) for 28 days. Serum selenium concentrations in the control group did not change significantly during the 28 day period (65.22 μg/L on 1st day and 64,35 μg/L on 28th day) and were significantly lower than those in the experimental group from day 2 to day 28. The results of clinical examinations, analyses of hematological parameters, and liver and kidney function tests showed that selenitetriglycerides had no adverse effect on the health or on the metabolic or haematological statuses of the cows. These findings indicate that selenitetriglycerides are safe and effective selenium supplements for cattle.
- Klíčová slova
- biochemical parameters, cattle, haematology, selenitetriglycerides, selenium,
- MeSH
- aspartátaminotransferasy krev metabolismus MeSH
- cholesterol krev MeSH
- gama-glutamyltransferasa krev metabolismus MeSH
- játra účinky léků MeSH
- kreatinin krev MeSH
- kreatinkinasa krev metabolismus MeSH
- krevní glukóza MeSH
- krevní proteiny MeSH
- kyseliny mastné neesterifikované krev MeSH
- L-laktátdehydrogenasa krev metabolismus MeSH
- ledviny účinky léků MeSH
- močovina krev MeSH
- potravní doplňky MeSH
- selen krev MeSH
- skot krev metabolismus MeSH
- sloučeniny selenu chemie farmakologie MeSH
- triglyceridy krev chemie farmakologie MeSH
- zvířata MeSH
- Check Tag
- skot krev metabolismus MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- randomizované kontrolované studie veterinární MeSH
- Názvy látek
- aspartátaminotransferasy MeSH
- cholesterol MeSH
- gama-glutamyltransferasa MeSH
- kreatinin MeSH
- kreatinkinasa MeSH
- krevní glukóza MeSH
- krevní proteiny MeSH
- kyseliny mastné neesterifikované MeSH
- L-laktátdehydrogenasa MeSH
- močovina MeSH
- selen MeSH
- sloučeniny selenu MeSH
- triglyceridy MeSH
