-
Autor
Antelmi, Elena 1 Barateau, Lucie 1 Bassetti, Claudio L A 1 Bušková, Jitka 1 Dauvilliers, Yves 1 Del Rio Villegas, Rafael 1 Feketeova, Eva 1 Fronczek, Rolf 1 Gaig, Carles 1 Gool, Jari K 1 Heinzer, Raphaël 1 Högl, Birgit 1 Khatami, Ramin 1 Lammers, Gert Jan 1 Manconi, Mauro 1 Mayer, Geert 1 Overeem, Sebastiaan 1 Partinen, Markku 1 Peraita-Adrados, Rosa 1 Pizza, Fabio 1
-
Pracoviště
Center for Investigation and Research... 1 Center for Sleep Medicine Sleep Resea... 1 Department of Biomedical Metabolic an... 1 Department of Biomedical and Neuromot... 1 Department of Clinical Neurophysiolog... 1 Department of Neurology Inselspital B... 1 Department of Neurology Sechenov 1st ... 1 Department of Neurology and Clinical ... 1 Department of Sleep Medicine National... 1 Eindhoven University of Technology Ei... 1 Helsinki Sleep Clinic Vitalmed Resear... 1 IRCCS Istituto delle Scienze Neurolog... 1 Institute for Neurosciences of Montpe... 1 National Reference Centre for Orphan ... 1 Neurology Department EOC Ospedale Reg... 1 Neurology Department Hephata Klinik S... 1 Neurology Department Medical Faculty ... 1 Neurology Department Sleep Disorders ... 1 Neurology Department and Centre of Cl... 1 Neurology Service Institut de Neuroci... 1
- Publikační typ
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Nejvíce citované
-
Autor
Antelmi, Elena 1 Barateau, Lucie 1 Bassetti, Claudio L A 1 Bušková, Jitka 1 Dauvilliers, Yves 1 Del Rio Villegas, Rafael 1 Feketeova, Eva 1 Fronczek, Rolf 1 Gaig, Carles 1 Gool, Jari K 1 Heinzer, Raphaël 1 Högl, Birgit 1 Khatami, Ramin 1 Lammers, Gert Jan 1 Manconi, Mauro 1 Mayer, Geert 1 Overeem, Sebastiaan 1 Partinen, Markku 1 Peraita-Adrados, Rosa 1 Pizza, Fabio 1
-
Pracoviště
Center for Investigation and Research... 1 Center for Sleep Medicine Sleep Resea... 1 Department of Biomedical Metabolic an... 1 Department of Biomedical and Neuromot... 1 Department of Clinical Neurophysiolog... 1 Department of Neurology Inselspital B... 1 Department of Neurology Sechenov 1st ... 1 Department of Neurology and Clinical ... 1 Department of Sleep Medicine National... 1 Eindhoven University of Technology Ei... 1 Helsinki Sleep Clinic Vitalmed Resear... 1 IRCCS Istituto delle Scienze Neurolog... 1 Institute for Neurosciences of Montpe... 1 National Reference Centre for Orphan ... 1 Neurology Department EOC Ospedale Reg... 1 Neurology Department Hephata Klinik S... 1 Neurology Department Medical Faculty ... 1 Neurology Department Sleep Disorders ... 1 Neurology Department and Centre of Cl... 1 Neurology Service Institut de Neuroci... 1
- Publikační typ
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Nejvíce citované
- Zhang, Zhongxing
-
Dauvilliers, Yves
Autor Dauvilliers, Yves Sleep-Wake Disorders Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, Montpellier, France National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, and Kleine-Levin Syndrome, Montpellier, France Institute for Neurosciences of Montpellier INM, Univ Montpellier, INSERM, Montpellier, France
- Plazzi, Giuseppe
- Mayer, Geert
- Lammers, Gert Jan
- Santamaria, Joan
- Partinen, Markku
- Overeem, Sebastiaan
- Del Rio Villegas, Rafael
- Sonka, Karel
PubMed
35669411
PubMed Central
PMC9166906
DOI
10.2147/nss.s359980
PII: 359980
Knihovny.cz E-zdroje
PURPOSE: Narcolepsy type-1 (NT1) is a rare chronic neurological sleep disorder with excessive daytime sleepiness (EDS) as usual first and cataplexy as pathognomonic symptom. Shortening the NT1 diagnostic delay is the key to reduce disease burden and related low quality of life. Here we investigated the changes of diagnostic delay over the diagnostic years (1990-2018) and the factors associated with the delay in Europe. PATIENTS AND METHODS: We analyzed 580 NT1 patients (male: 325, female: 255) from 12 European countries using the European Narcolepsy Network database. We combined machine learning and linear mixed-effect regression to identify factors associated with the delay. RESULTS: The mean age at EDS onset and diagnosis of our patients was 20.9±11.8 (mean ± standard deviation) and 30.5±14.9 years old, respectively. Their mean and median diagnostic delay was 9.7±11.5 and 5.3 (interquartile range: 1.7-13.2 years) years, respectively. We did not find significant differences in the diagnostic delay over years in either the whole dataset or in individual countries, although the delay showed significant differences in various countries. The number of patients with short (≤2-year) and long (≥13-year) diagnostic delay equally increased over decades, suggesting that subgroups of NT1 patients with variable disease progression may co-exist. Younger age at cataplexy onset, longer interval between EDS and cataplexy onsets, lower cataplexy frequency, shorter duration of irresistible daytime sleep, lower daytime REM sleep propensity, and being female are associated with longer diagnostic delay. CONCLUSION: Our findings contrast the results of previous studies reporting shorter delay over time which is confounded by calendar year, because they characterized the changes in diagnostic delay over the symptom onset year. Our study indicates that new strategies such as increasing media attention/awareness and developing new biomarkers are needed to better detect EDS, cataplexy, and changes of nocturnal sleep in narcolepsy, in order to shorten the diagnostic interval.
- Klíčová slova
- cataplexy, diagnostic delay, machine learning, misdiagnosis, symptom onset,
- Publikační typ
- časopisecké články MeSH
Upřesnit dle MeSH
Sdílet
Název dokumentu
Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.