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Autor
Almond, Max 1 Biasoni, Davide 1 Cananzi, Ferdinando Carlo Maria 1 Cardona, Kenneth 1 Chen, Jun 1 Cioffi, Stefano Piero Bernardo 1 Evenden, Caroline 1 Fairweather, Mark 1 Farma, Jeffrey M 1 Fiore, Marco 1 Ford, Samuel J 1 Fukushima, Suguru 1 Gamboa, Adriana 1 Gladdy, Rebecca A 1 Greco, Stephanie H 1 Gronchi, Alessandro 1 Hompes, Daphne 1 Howlett-Jansen, Ynez 1 Iwata, Shintaro 1 Johnston, Wendy 1
- Organizace
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Pracoviště
Center for Sarcoma and Bone Oncology ... 1 College of Osteopathic Medicine of th... 1 Department of Biomedical Sciences Hum... 1 Department of Cancer Surgery Peter Ma... 1 Department of Comprehensive Cancer Ca... 1 Department of Medical Oncology Bern U... 1 Department of Medical Oncology Campus... 1 Department of Paediatric Oncology Uni... 1 Department of Retroperitoneal Tumor S... 1 Department of Soft Tissue Bone Sarcom... 1 Department of Surgery Brigham and Wom... 1 Department of Surgery Fondazione IRCC... 1 Department of Surgery The Ottawa Hosp... 1 Department of Surgery University of W... 1 Department of Surgical Oncology Fox C... 1 Department of Surgical Oncology Insti... 1 Department of Surgical Oncology Insti... 1 Department of Surgical Oncology Mount... 1 Department of Surgical Oncology Royal... 1 Department of Surgical Oncology The U... 1
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- Země
- Časopis/zdroj
- Země - grant
- Grantová agentura
- Nejvíce citované
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Autor
Almond, Max 1 Biasoni, Davide 1 Cananzi, Ferdinando Carlo Maria 1 Cardona, Kenneth 1 Chen, Jun 1 Cioffi, Stefano Piero Bernardo 1 Evenden, Caroline 1 Fairweather, Mark 1 Farma, Jeffrey M 1 Fiore, Marco 1 Ford, Samuel J 1 Fukushima, Suguru 1 Gamboa, Adriana 1 Gladdy, Rebecca A 1 Greco, Stephanie H 1 Gronchi, Alessandro 1 Hompes, Daphne 1 Howlett-Jansen, Ynez 1 Iwata, Shintaro 1 Johnston, Wendy 1
- Organizace
-
Pracoviště
Center for Sarcoma and Bone Oncology ... 1 College of Osteopathic Medicine of th... 1 Department of Biomedical Sciences Hum... 1 Department of Cancer Surgery Peter Ma... 1 Department of Comprehensive Cancer Ca... 1 Department of Medical Oncology Bern U... 1 Department of Medical Oncology Campus... 1 Department of Paediatric Oncology Uni... 1 Department of Retroperitoneal Tumor S... 1 Department of Soft Tissue Bone Sarcom... 1 Department of Surgery Brigham and Wom... 1 Department of Surgery Fondazione IRCC... 1 Department of Surgery The Ottawa Hosp... 1 Department of Surgery University of W... 1 Department of Surgical Oncology Fox C... 1 Department of Surgical Oncology Insti... 1 Department of Surgical Oncology Insti... 1 Department of Surgical Oncology Mount... 1 Department of Surgical Oncology Royal... 1 Department of Surgical Oncology The U... 1
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- Země - grant
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PubMed
35866666
PubMed Central
PMC10191524
DOI
10.1097/sla.0000000000005625
PII: 00000658-202308000-00018
Knihovny.cz E-zdroje
OBJECTIVE: The Transatlantic Australasian Retroperitoneal Sarcoma Working Group conducted a retrospective study on the disease course and clinical management of ganglioneuromas. BACKGROUND: Ganglioneuromas are rare tumors derived from neural crest cells. Data on these tumors remain limited to case reports and single-institution case series. METHODS: Patients of all ages with pathologically confirmed primary retroperitoneal, intra-abdominal, and pelvic ganglioneuromas between January 1, 2000, and January 1, 2020, were included. We examined demographic, clinicopathologic, and radiologic characteristics, as well as clinical management. RESULTS: Overall, 328 patients from 29 institutions were included. The median age at diagnosis was 37 years with 59.1% of patients being female. Symptomatic presentation comprised 40.9% of cases, and tumors were often located in the extra-adrenal retroperitoneum (67.1%). At baseline, the median maximum tumor diameter was 7.2 cm. One hundred sixteen (35.4%) patients underwent active surveillance, whereas 212 (64.6%) patients underwent resection with 74.5% of operative cases achieving an R0/R1 resection. Serial tumor evaluations showed that malignant transformation to neuroblastoma was rare (0.9%, N=3). Tumors undergoing surveillance had a median follow-up of 1.9 years, with 92.2% of ganglioneuromas stable in size. With a median follow-up of 3.0 years for resected tumors, 84.4% of patients were disease free after resections, whereas recurrences were observed in 4 (1.9%) patients. CONCLUSIONS: Most ganglioneuromas have indolent disease courses and rarely transform to neuroblastoma. Thus, active surveillance may be appropriate for benign and asymptomatic tumors particularly when the risks of surgery outweigh the benefits. For symptomatic or growing tumors, resection may be curative.
- MeSH
- dospělí MeSH
- ganglioneurom * chirurgie MeSH
- lidé MeSH
- nádory měkkých tkání * MeSH
- neuroblastom * MeSH
- progrese nemoci MeSH
- retroperitoneální nádory * chirurgie MeSH
- retrospektivní studie MeSH
- sarkom * chirurgie patologie MeSH
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- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
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