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Hubacek, Jaroslav A
Autor Hubacek, Jaroslav A ORCID Experimental Medicine Centre, Institute for Clinical and Experimental Medicine, IKEM-CEM-LMG, Videnska 1958/9, 140 21, Prague 4, Czech Republic. jahb@ikem.cz 3rd Department of Internal Medicine, 1st Faculty of Medicine, Charles University, Prague, Czech Republic. jahb@ikem.cz
- Adamkova, Vera
- Lanska, Vera
- Staněk, Vladimir
- Mrázková, Jolana
- Gebauerová, Marie
- Kettner, Jiri
- Kautzner, Josef
- Pitha, Jan
PubMed
38252350
PubMed Central
PMC10803395
DOI
10.1007/s11033-023-09128-3
PII: 10.1007/s11033-023-09128-3
Knihovny.cz E-zdroje
BACKGROUND: Despite a general decline in mean levels across populations, LDL-cholesterol levels remain a major risk factor for acute coronary syndrome (ACS). The APOB, LDL-R, CILP, and SORT-1 genes have been shown to contain variants that have significant effects on plasma cholesterol levels. METHODS AND RESULTS: We examined polymorphisms within these genes in 1191 controls and 929 patients with ACS. Only rs646776 within SORT-1 was significantly associated with a risk of ACS (P < 0.05, AA vs. + G comparison; OR 1.21; 95% CI 1.01-1.45). With regard to genetic risk score (GRS), the presence of at least 7 alleles associated with elevated cholesterol levels was connected with increased risk (P < 0.01) of ACS (OR 1.26; 95% CI 1.06-1.52). Neither total mortality nor CVD mortality in ACS subjects (follow up-9.84 ± 3.82 years) was associated with the SNPs analysed or cholesterol-associated GRS. CONCLUSIONS: We conclude that, based on only a few potent SNPs known to affect plasma cholesterol, GRS has the potential to predict ACS risk, but not ACS associated mortality.
- Klíčová slova
- Acute coronary syndrome, Cholesterol, Polymorphism, Risk estimation,
- MeSH
- akutní koronární syndrom * genetika MeSH
- cholesterol MeSH
- genetické rizikové skóre * MeSH
- jednonukleotidový polymorfismus genetika MeSH
- lidé MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika epidemiologie MeSH
- Názvy látek
- cholesterol MeSH
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Název dokumentu
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