AIM: Adalimumab effectiveness on clinical, functional and work-related outcomes was evaluated in patients with active ankylosing spondylitis or psoriatic arthritis treated in routine clinical practice in central-eastern Europe. METHODS: Patients (n = 555) were followed for 12 months. Primary end point was percentage of patients with a treatment response (≥50% decrease from baseline in Bath Ankylosing Spondylitis Disease Activity Index or ≥1.2 point decrease from baseline in Disease Activity Index-28 joint for axial or peripheral symptoms, respectively). Functional status was evaluated by the Bath Ankylosing Spondylitis Functional Index and Health Assessment Questionnaire Disability Index. Working ability was evaluated by the Work Productivity and Activity Impairment Questionnaire - Specific Health Problem. RESULTS: 76.1% of patients with axial symptoms and 83.5% with peripheral symptoms achieved a treatment response. Frequency of extra-articular manifestations decreased. Improvements were observed in functional status and workability. No new safety signals were observed. CONCLUSION: Adalimumab was effective and well tolerated during real-world use in central-eastern Europe.

• Klíčová slova
• adalimumab, ankylosing spondylitis, extra-articular manifestations, observational study, psoriatic arthritis, workability,
• MeSH
• adalimumab terapeutické užití   MeSH
• ankylózující spondylitida farmakoterapie   MeSH
• antirevmatika terapeutické užití   MeSH
• humanizované monoklonální protilátky MeSH
• lidé MeSH
• následné studie MeSH
• psoriatická artritida farmakoterapie   MeSH
• výsledek terapie MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Evropa MeSH
• východní Evropa MeSH
• Názvy látek
• adalimumab MeSH
• antirevmatika MeSH
• humanizované monoklonální protilátky MeSH