Perinatal hypoxic-ischemic insult (HII) is one of the main devastating causes of morbidity and mortality in newborns. HII induces brain injury which evolves to neurological sequelae later in life. Hypothermia is the only therapeutic approach available capable of diminishing brain impairment after HII. Finding a novel therapeutic method to reduce the severity of brain injury and its consequences is critical in neonatology. The present paper aimed to evaluate the effect of sulforaphane (SFN) pre-treatment on glucose metabolism, neurodegeneration, and functional outcome at the acute, sub-acute, and sub-chronic time intervals in the experimental model of perinatal hypoxic-ischemic insult in rats. To estimate the effect of SFN on brain glucose uptake we have performed 18F-deoxyglucose (FDG) microCT/PET. The activity of FDG was determined in the hippocampus and sensorimotor cortex. Neurodegeneration was assessed by histological analysis of Nissl-stained brain sections. To investigate functional outcomes a battery of behavioral tests was employed. We have shown that although SFN possesses a protective effect on glucose uptake in the ischemic hippocampus 24 h and 1 week after HII, no effect has been observed in the motor cortex. We have further shown that the ischemic hippocampal formation tends to be thinner in HIE and SFN treatment tends to reverse this pattern. We have observed subtle chronic movement deficit after HII detected by ladder rung walking test with no protective effect of SFN. SFN should be thus considered as a potent neuroprotective drug with the capability to interfere with pathophysiological processes triggered by perinatal hypoxic-ischemic insult.
- MeSH
- fluorodeoxyglukosa F18 terapeutické užití MeSH
- glukosa MeSH
- hypoxie komplikace MeSH
- isothiokyanatany MeSH
- krysa rodu Rattus MeSH
- mozek diagnostické zobrazování patologie MeSH
- mozková hypoxie a ischemie * diagnostické zobrazování farmakoterapie MeSH
- novorozená zvířata MeSH
- poranění mozku * MeSH
- sulfoxidy MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- fluorodeoxyglukosa F18 MeSH
- glukosa MeSH
- isothiokyanatany MeSH
- sulforaphane MeSH Prohlížeč
- sulfoxidy MeSH
- MeSH
- antiplatyhelmintické látky terapeutické užití MeSH
- Fasciola hepatica účinky léků MeSH
- fasciolóza farmakoterapie parazitologie MeSH
- myši MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antiplatyhelmintické látky MeSH
The effects of terguride on the uterotonic activity of rat's uterine stria were investigated by means of a standardized isometric method of measuring in vitro the contractility of uterine muscles. The uterotonic activity of the given preparation depends on its concentration and on the phase of uterine cycle. The uterotonic activity makes 71.4 U.mg-1 in the range of terguride concentrations from 10(-7) to 10(-5) mg per ml. Used at higher concentrations, the uterotonic activity of terguride is very low. Spontaneous contractions are moderated and the tone of uterus is decreased by terguride administration.
- MeSH
- děložní kontrakce účinky léků MeSH
- inbrední kmeny potkanů MeSH
- krysa rodu Rattus MeSH
- lisurid analogy a deriváty farmakologie MeSH
- techniky in vitro MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- Názvy látek
- dironyl MeSH Prohlížeč
- lisurid MeSH
From 3-(3,4-dimethoxyphenyl)propenic acid chloride and substituted amines and hydrazides, the appropriate amides and hydrazides (Table 1) were synthesized at 60-80 degrees C in the medium of benzene or toluene. The reaction of this chloride with benzaldehyde hydrazone at 70-80 degrees C yielded N,N'-bis[3-(3,4-dimethoxyphenyl)propenoyl]hydrazine (VIII). At ambient temperature the benzylidene hydrazide of 3-(3,4-dimethoxyphenyl)propenic acid (VII) and a small amount of compound VIII were isolated. In the reaction of 3-(3,4-dimethoxyphenyl)propenic acid chloride with benzylidene hydrazide (VII) at 70-80 degrees C, compound VIII was obtained (Scheme 1). Compounds I, VII, VIII and IX possessed higher indices of increase in fortnight tests of the first degree in the roosters of meat hybrides compared to the negative control, but the indices of conversion were unfavourable. The compounds did not reach the efficacy of the avoparcin standard. Derivatives II and VI possessed 67.5 and 63.5%, respectively, of anthelmintic activity of levamisol against Nippostrongylus brasiliensis. The prepared compounds were not antibacterially effective and they were not mutagenic in the tests following the method of Ames, either.
- MeSH
- Bacteria účinky léků MeSH
- cinnamáty chemická syntéza farmakologie MeSH
- léčivé přípravky * MeSH
- Nippostrongylus účinky léků MeSH
- testy genotoxicity MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- Názvy látek
- 3-(3,4-dimethoxyphenyl)propenoic acid MeSH Prohlížeč
- cinnamáty MeSH
- léčivé přípravky * MeSH
A reaction of potassium thiocyanate with methyl and ethyl ester of chloroformic acid (I-II) resulted in methoxy- and ethoxycarbonyl isothiocyanates which through an addition reaction with various primary and secondary amines, diamines and hydrazines yielded the perinently substituted esters of thioallophanic acid (III-XXI). The obtained agents were tested for anthelmintic and anticoccidial effects.
- MeSH
- anthelmintika * farmakologie MeSH
- Eimeria účinky léků MeSH
- Hymenolepis účinky léků MeSH
- Nippostrongylus účinky léků MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- Názvy látek
- anthelmintika * MeSH
The authors describe rare complications of advanced colorectal carcinoma--duodenocolic fistulae, which unless removed by surgery, soon kill the patient. The authors draw attention to the clinical picture where rapidly developing dehydration, anaemia and general cachexia predominate. After short-term preoperative preparation (adequate parenteral nutrition, transfusion of blood and blood derivatives, antibiotics etc.), the authors recommend, consistent with data in the literature, radical surgery, i.e. right-sided pancreatectomy with right-sided hemicolectomy or at least right-sided hemicolectomy with excision of the fistula on the duodenum and intense postoperative care. Bypass operations are recommended as palliative operations where radical operation is not possible for some reason. A malignant duodenocolic fistula as a complication of an advanced malignant disease in a very exhausted patient may fail even after a radical, technically perfect operation and intense preoperative and postoperative care.
- MeSH
- kolorektální nádory komplikace MeSH
- lidé středního věku MeSH
- lidé MeSH
- nemoci duodena etiologie chirurgie MeSH
- nemoci tlustého střeva etiologie chirurgie MeSH
- senioři MeSH
- střevní píštěle etiologie chirurgie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- kazuistiky MeSH
The authors describe the case of an intramural duodenal haematoma caused a high ileus after a seven-day post-traumatic interval. The authors recommend surgical revision, in particular in children because the mechanism of injury is the same in intramural haematoma and in duodenal perforation. Only thus it is possible to prevena a fatal course, while the operation is easy and healing after drainage of the haematoma is rapid.
- MeSH
- dítě MeSH
- hematom komplikace diagnostické zobrazování chirurgie MeSH
- lidé MeSH
- obstrukce duodena diagnostické zobrazování etiologie chirurgie MeSH
- poranění břicha komplikace MeSH
- radiografie MeSH
- tupá poranění komplikace MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
The reaction of potassium thiocyanate with the methyl- and ethyl esters of chloroformic acid (V-VI) in acetone resulted in methoxy- and ethoxycarbonylisothiocyanates which were converted without isolation by means of an addition reaction with 2-alkyl-5,6-diaminobenzimidazoles (I-IV) into the pertinent 2-alkyl-5,6-bis (3-alkoxycarbonyl-2-thioureido) benzimidazoles (VII-XV). The substances obtained were tested for anthelmintic and anticoccidial effectiveness. In anthelmintic screening, substances VIII, IX, XI, XII, XIV and XV were significantly effective against the taenia Hymenolepis nana.
- MeSH
- anthelmintika * MeSH
- benzimidazoly farmakologie MeSH
- Hymenolepis účinky léků MeSH
- myši MeSH
- Nippostrongylus účinky léků MeSH
- thiomočovina analogy a deriváty farmakologie MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- Názvy látek
- anthelmintika * MeSH
- benzimidazoly MeSH
- thiomočovina MeSH
The authors describe the case of a practical amputation of the proximal portion of the left forearm which occurred at a time when the development of microsurgical technique was in its initial stages in the CSSR and which was resolved at he level of a district institute of national health. The authors describe the surgical procedure, postoperative treatment and complications. The authors discuss general principles which should be respected in the event of similar injuries under present conditions.
- MeSH
- lidé středního věku MeSH
- lidé MeSH
- poranění předloktí diagnostické zobrazování chirurgie MeSH
- předloktí diagnostické zobrazování chirurgie MeSH
- radiografie MeSH
- replantace metody MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- MeSH
- dospělí MeSH
- familiární adenomatózní polypóza * diagnóza genetika chirurgie MeSH
- lidé středního věku MeSH
- lidé MeSH
- rodokmen MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- kazuistiky MeSH
