• Klíčová slova
• Alzheimer's disease, Behcet’s disease, RIPK2, Sjögren’s syndrome, immunopharmacology, immunotargets, neuroinflammation, oligodeoxynucleotides,
• Publikační typ
• úvodníky MeSH

Ovarian cancer is one of the most common malignancies in women and contributes greatly to cancer-related deaths. Tumor suppressor candidate 3 (TUSC3) is a putative tumor suppressor gene located at chromosomal region 8p22, which is often lost in epithelial cancers. Epigenetic silencing of TUSC3 has been associated with poor prognosis, and hypermethylation of its promoter provides an independent biomarker of overall and disease-free survival in ovarian cancer patients. TUSC3 is localized to the endoplasmic reticulum in an oligosaccharyl tranferase complex responsible for the N-glycosylation of proteins. However, the precise molecular role of TUSC3 in ovarian cancer remains unclear. In this study, we establish TUSC3 as a novel ovarian cancer tumor suppressor using a xenograft mouse model and demonstrate that loss of TUSC3 alters the molecular response to endoplasmic reticulum stress and induces hallmarks of the epithelial-to-mesenchymal transition in ovarian cancer cells. In summary, we have confirmed the tumor-suppressive function of TUSC3 and identified the possible mechanism driving TUSC3-deficient ovarian cancer cells toward a malignant phenotype.

• Klíčová slova
• N33, TUSC3, endoplasmic reticulum stress, epithelial-to-mesenchymal transition, ovarian cancer, tumor suppressor,
• MeSH
• epitelo-mezenchymální tranzice genetika   MeSH
• heterografty MeSH
• lidé MeSH
• membránové proteiny genetika   MeSH
• myši inbrední NOD MeSH
• myši SCID MeSH
• myši MeSH
• nádorové buněčné linie MeSH
• nádorové supresorové proteiny genetika   MeSH
• nádory vaječníků genetika   MeSH
• stres endoplazmatického retikula genetika   MeSH
• tumor supresorové geny fyziologie   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• myši MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• membránové proteiny MeSH
• nádorové supresorové proteiny MeSH
• TUSC3 protein, human MeSH Prohlížeč